The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers

Transformation and cancer growth are regulated by the coordinate actions of oncogenes and tumor suppressors. Here, we show that the novel E3 ubiquitin ligase HACE1 is frequently downregulated in human tumors and maps to a region of chromosome 6q21 implicated in multiple human cancers. Genetic inacti...

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Veröffentlicht in:	Nature medicine 2007-09, Vol.13 (9), p.1060-1069
Hauptverfasser:	Hara, Hiromitsu, Wada, Teiji, Liu, Peter P, Nghiem, Mai P, Cronin, Shane, Melnyk, Nataliya, Zhang, Liyong, Penninger, Josef M, Sorensen, Poul H, Sarao, Renu, O'Sullivan, Maureen, Anglesio, Michael S, Yang, Ge, Zhang, Fan, Farrar, Jason, Li, Liheng, Arceci, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Ankyrin Repeat - genetics Cancer Cell cycle Chromosome Mapping Chromosomes Chromosomes, Human, Pair 6 DNA Methylation Gene expression Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Genetic aspects Genetic Predisposition to Disease Health aspects Humans Inactivation Kidney Neoplasms - genetics Ligases Medical research Mice Mice, Mutant Strains RNA, Messenger - genetics Rodents Tumor suppressor genes Tumors Ubiquitin-Protein Ligases - genetics Wilms Tumor - genetics
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