Transcription of bxd Noncoding RNAs Promoted by Trithorax Represses Ubx in cis by Transcriptional Interference

Much of the genome is transcribed into long noncoding RNAs (ncRNAs). Previous data suggested that bithoraxoid ( bxd) ncRNAs of the Drosophila bithorax complex (BX-C) prevent silencing of Ultrabithorax ( Ubx) and recruit activating proteins of the trithorax group (trxG) to their maintenance elements...

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Veröffentlicht in:	Cell 2006-12, Vol.127 (6), p.1209-1221
Hauptverfasser:	Petruk, Svetlana, Sedkov, Yurii, Riley, Kristen M., Hodgson, Jacob, Schweisguth, Francois, Hirose, Susumu, Jaynes, James B., Brock, Hugh W., Mazo, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleus Chromosomal Proteins, Non-Histone - metabolism Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Female Gene Expression Regulation Genes, Insect Histones - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Larva - genetics Larva - metabolism Promoter Regions, Genetic RNA, Untranslated - genetics Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Transcriptional Elongation Factors - metabolism
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