Interleukin-13 receptor–targeted nanovesicles are a potential therapy for glioblastoma multiforme

The difficulties associated with treatment of malignant brain tumors are well documented. For example, local infiltration of high-grade astrocytomas prevents the complete resection of all malignant cells. It is, therefore, critical to develop delivery systems for chemotherapeutic agents that ablate...

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Veröffentlicht in:	Molecular cancer therapeutics 2006-12, Vol.5 (12), p.3162-3169
Hauptverfasser:	A.B. Madhankumar, Becky Slagle-Webb, Akiva Mintz, Jonas M. Sheehan, James R. Connor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals blood-brain barrier Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Cell Line, Tumor doxorubicin Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Drug Delivery Systems - methods Female Glioblastoma - drug therapy Glioblastoma - metabolism glioma Humans interleukin-13 Interleukin-13 - administration & dosage Interleukin-13 - pharmacokinetics liposomes Liposomes - administration & dosage Liposomes - pharmacokinetics Mice Mice, Nude Nanoparticles - administration & dosage Receptors, Interleukin-13 - metabolism Xenograft Model Antitumor Assays
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