Parathyroid hormone‐related protein varies with sex and androgen status in nonsmall cell lung cancer
BACKGROUND. In nonsmall cell lung cancer, tumor parathyroid hormone‐related protein (PTHrP) expression predicts longer survival in women but not in men. To explain the sex‐dependent survival effect, the authors proposed that hormonal influences decrease PTHrP in men versus women, that PTHrP inhibits...
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| creator | Montgrain, Philippe R. Quintana, Rick Rascon, Yvette Burton, Douglas W. Deftos, Leonard J. Casillas, Andrea Hastings, Randolph H. |
| description | BACKGROUND.
In nonsmall cell lung cancer, tumor parathyroid hormone‐related protein (PTHrP) expression predicts longer survival in women but not in men. To explain the sex‐dependent survival effect, the authors proposed that hormonal influences decrease PTHrP in men versus women, that PTHrP inhibits tumor growth, and that the effect is greater in women than in men. The objectives of this study were to compare lung carcinoma PTHrP expression and carcinoma growth in male and female mice and to determine whether gonadal steroids regulate PTHrP in lung cancer cells.
METHODS.
Tumor PTHrP content was measured by immunoassay, and tumor burden was assessed with multiple measures in BEN squamous cell orthotopic lung carcinomas in athymic mice. In addition, lung adenocarcinoma PTHrP messenger RNA (mRNA) values determined by microarray analyses were compared between men and women. Cultured lung cancer cells were assayed for PTHrP after treatment with estradiol or R1881, a synthetic androgen.
RESULTS.
Lung carcinomas contained approximately 3 times more PTHrP in female mice than in male mice. Similarly, levels of PTHrP mRNA were significantly greater in adenocarcinomas from patients who were women than from patients who were men. Male mice had greater tumor burden than female mice. Androgen treatment reduced PTHrP in 3 lung cancer lines. Estradiol had no effect. Testosterone treatment also reduced lung carcinoma PTHrP in female mice.
CONCLUSIONS.
Lung carcinomas in females expressed more PTHrP than in males possibly because of negative regulation by androgens in males. Female mice with higher tumor PTHrP content had significantly less tumor burden than male mice, supporting the hypothesis that PTHrP inhibits tumor growth. Cancer 2007. © 2007 American Cancer Society.
Parathyroid hormone‐related protein (PTHrP) was associated with prolonged survival in women, but not men, with nonsmall cell lung cancer. Androgen‐mediated decreases in PTHrP may be responsible for this sex dependence. |
| doi_str_mv | 10.1002/cncr.22922 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68253766</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68253766</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3932-ac0c6ef122e3e19e354dd7a946b89fa90c875c0f2336664d85a5bcad8f573fa53</originalsourceid><addsrcrecordid>eNp9kM1q3DAQx0VpaDYflzxA0KU9BJzqw5KlY1n6EQhpCQnkZmblUdbFllPJbrK3PkKfsU8SObuQWw8aMfDjPzM_Qk44O-eMiY8uuHguhBXiDVlwZquC8VK8JQvGmClUKe_2yUFKP3NbCSXfkX1e6UorYxbE_4AI43oTh7ah6yH2Q8B_f_5G7GDEhj7EYcQ20N8QW0z0sR3XNOEThdDMLw73GGgaYZwSzVgYQuqh66jDXLop3FMHwWE8InseuoTHu_-Q3H75fLP8Vlx-_3qx_HRZOGmlKMAxp9FzIVAityhV2TQV2FKvjPVgmTOVcswLKbXWZWMUqJWDxnhVSQ9KHpIP29y8-K8J01j3bZqXgYDDlGptsoBK6wyebUEXh5Qi-vohtj3ETc1ZPVutZ6v1i9UMn-5Sp1WPzSu605iB9zsAkoPOx3x0m145y0pl7BzEt9xj2-HmPyPr5dXyejv8GVjykhM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68253766</pqid></control><display><type>article</type><title>Parathyroid hormone‐related protein varies with sex and androgen status in nonsmall cell lung cancer</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Montgrain, Philippe R. ; Quintana, Rick ; Rascon, Yvette ; Burton, Douglas W. ; Deftos, Leonard J. ; Casillas, Andrea ; Hastings, Randolph H.</creator><creatorcontrib>Montgrain, Philippe R. ; Quintana, Rick ; Rascon, Yvette ; Burton, Douglas W. ; Deftos, Leonard J. ; Casillas, Andrea ; Hastings, Randolph H.</creatorcontrib><description>BACKGROUND.
In nonsmall cell lung cancer, tumor parathyroid hormone‐related protein (PTHrP) expression predicts longer survival in women but not in men. To explain the sex‐dependent survival effect, the authors proposed that hormonal influences decrease PTHrP in men versus women, that PTHrP inhibits tumor growth, and that the effect is greater in women than in men. The objectives of this study were to compare lung carcinoma PTHrP expression and carcinoma growth in male and female mice and to determine whether gonadal steroids regulate PTHrP in lung cancer cells.
METHODS.
Tumor PTHrP content was measured by immunoassay, and tumor burden was assessed with multiple measures in BEN squamous cell orthotopic lung carcinomas in athymic mice. In addition, lung adenocarcinoma PTHrP messenger RNA (mRNA) values determined by microarray analyses were compared between men and women. Cultured lung cancer cells were assayed for PTHrP after treatment with estradiol or R1881, a synthetic androgen.
RESULTS.
Lung carcinomas contained approximately 3 times more PTHrP in female mice than in male mice. Similarly, levels of PTHrP mRNA were significantly greater in adenocarcinomas from patients who were women than from patients who were men. Male mice had greater tumor burden than female mice. Androgen treatment reduced PTHrP in 3 lung cancer lines. Estradiol had no effect. Testosterone treatment also reduced lung carcinoma PTHrP in female mice.
CONCLUSIONS.
Lung carcinomas in females expressed more PTHrP than in males possibly because of negative regulation by androgens in males. Female mice with higher tumor PTHrP content had significantly less tumor burden than male mice, supporting the hypothesis that PTHrP inhibits tumor growth. Cancer 2007. © 2007 American Cancer Society.
Parathyroid hormone‐related protein (PTHrP) was associated with prolonged survival in women, but not men, with nonsmall cell lung cancer. Androgen‐mediated decreases in PTHrP may be responsible for this sex dependence.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.22922</identifier><identifier>PMID: 17676588</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - metabolism ; Androgens - administration & dosage ; Androgens - blood ; Androgens - metabolism ; Animals ; biologic tumor marker ; Biological and medical sciences ; Blotting, Western ; Carcinoma, Large Cell - metabolism ; Carcinoma, Non-Small-Cell Lung - blood ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Squamous Cell - metabolism ; Female ; Gene Expression Regulation, Neoplastic ; gonadal hormones ; Gonadal Steroid Hormones - metabolism ; growth substances ; Humans ; Lung Neoplasms - blood ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Male ; Medical sciences ; Mice ; Mice, Nude ; parathyroid hormone receptor type 1 ; Parathyroid Hormone-Related Protein - blood ; Parathyroid Hormone-Related Protein - metabolism ; Pneumology ; Reverse Transcriptase Polymerase Chain Reaction ; Sex Factors ; steroid receptors ; Tumor Burden ; Tumors ; Tumors of the respiratory system and mediastinum</subject><ispartof>Cancer, 2007-09, Vol.110 (6), p.1313-1320</ispartof><rights>Copyright © 2007 American Cancer Society</rights><rights>2007 INIST-CNRS</rights><rights>(c) 2007 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3932-ac0c6ef122e3e19e354dd7a946b89fa90c875c0f2336664d85a5bcad8f573fa53</citedby><cites>FETCH-LOGICAL-c3932-ac0c6ef122e3e19e354dd7a946b89fa90c875c0f2336664d85a5bcad8f573fa53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.22922$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.22922$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19045892$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17676588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montgrain, Philippe R.</creatorcontrib><creatorcontrib>Quintana, Rick</creatorcontrib><creatorcontrib>Rascon, Yvette</creatorcontrib><creatorcontrib>Burton, Douglas W.</creatorcontrib><creatorcontrib>Deftos, Leonard J.</creatorcontrib><creatorcontrib>Casillas, Andrea</creatorcontrib><creatorcontrib>Hastings, Randolph H.</creatorcontrib><title>Parathyroid hormone‐related protein varies with sex and androgen status in nonsmall cell lung cancer</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND.
In nonsmall cell lung cancer, tumor parathyroid hormone‐related protein (PTHrP) expression predicts longer survival in women but not in men. To explain the sex‐dependent survival effect, the authors proposed that hormonal influences decrease PTHrP in men versus women, that PTHrP inhibits tumor growth, and that the effect is greater in women than in men. The objectives of this study were to compare lung carcinoma PTHrP expression and carcinoma growth in male and female mice and to determine whether gonadal steroids regulate PTHrP in lung cancer cells.
METHODS.
Tumor PTHrP content was measured by immunoassay, and tumor burden was assessed with multiple measures in BEN squamous cell orthotopic lung carcinomas in athymic mice. In addition, lung adenocarcinoma PTHrP messenger RNA (mRNA) values determined by microarray analyses were compared between men and women. Cultured lung cancer cells were assayed for PTHrP after treatment with estradiol or R1881, a synthetic androgen.
RESULTS.
Lung carcinomas contained approximately 3 times more PTHrP in female mice than in male mice. Similarly, levels of PTHrP mRNA were significantly greater in adenocarcinomas from patients who were women than from patients who were men. Male mice had greater tumor burden than female mice. Androgen treatment reduced PTHrP in 3 lung cancer lines. Estradiol had no effect. Testosterone treatment also reduced lung carcinoma PTHrP in female mice.
CONCLUSIONS.
Lung carcinomas in females expressed more PTHrP than in males possibly because of negative regulation by androgens in males. Female mice with higher tumor PTHrP content had significantly less tumor burden than male mice, supporting the hypothesis that PTHrP inhibits tumor growth. Cancer 2007. © 2007 American Cancer Society.
Parathyroid hormone‐related protein (PTHrP) was associated with prolonged survival in women, but not men, with nonsmall cell lung cancer. Androgen‐mediated decreases in PTHrP may be responsible for this sex dependence.</description><subject>Adenocarcinoma - metabolism</subject><subject>Androgens - administration & dosage</subject><subject>Androgens - blood</subject><subject>Androgens - metabolism</subject><subject>Animals</subject><subject>biologic tumor marker</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Carcinoma, Large Cell - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - blood</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>gonadal hormones</subject><subject>Gonadal Steroid Hormones - metabolism</subject><subject>growth substances</subject><subject>Humans</subject><subject>Lung Neoplasms - blood</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>parathyroid hormone receptor type 1</subject><subject>Parathyroid Hormone-Related Protein - blood</subject><subject>Parathyroid Hormone-Related Protein - metabolism</subject><subject>Pneumology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Sex Factors</subject><subject>steroid receptors</subject><subject>Tumor Burden</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1q3DAQx0VpaDYflzxA0KU9BJzqw5KlY1n6EQhpCQnkZmblUdbFllPJbrK3PkKfsU8SObuQWw8aMfDjPzM_Qk44O-eMiY8uuHguhBXiDVlwZquC8VK8JQvGmClUKe_2yUFKP3NbCSXfkX1e6UorYxbE_4AI43oTh7ah6yH2Q8B_f_5G7GDEhj7EYcQ20N8QW0z0sR3XNOEThdDMLw73GGgaYZwSzVgYQuqh66jDXLop3FMHwWE8InseuoTHu_-Q3H75fLP8Vlx-_3qx_HRZOGmlKMAxp9FzIVAityhV2TQV2FKvjPVgmTOVcswLKbXWZWMUqJWDxnhVSQ9KHpIP29y8-K8J01j3bZqXgYDDlGptsoBK6wyebUEXh5Qi-vohtj3ETc1ZPVutZ6v1i9UMn-5Sp1WPzSu605iB9zsAkoPOx3x0m145y0pl7BzEt9xj2-HmPyPr5dXyejv8GVjykhM</recordid><startdate>20070915</startdate><enddate>20070915</enddate><creator>Montgrain, Philippe R.</creator><creator>Quintana, Rick</creator><creator>Rascon, Yvette</creator><creator>Burton, Douglas W.</creator><creator>Deftos, Leonard J.</creator><creator>Casillas, Andrea</creator><creator>Hastings, Randolph H.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070915</creationdate><title>Parathyroid hormone‐related protein varies with sex and androgen status in nonsmall cell lung cancer</title><author>Montgrain, Philippe R. ; Quintana, Rick ; Rascon, Yvette ; Burton, Douglas W. ; Deftos, Leonard J. ; Casillas, Andrea ; Hastings, Randolph H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3932-ac0c6ef122e3e19e354dd7a946b89fa90c875c0f2336664d85a5bcad8f573fa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Androgens - administration & dosage</topic><topic>Androgens - blood</topic><topic>Androgens - metabolism</topic><topic>Animals</topic><topic>biologic tumor marker</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Carcinoma, Large Cell - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - blood</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>gonadal hormones</topic><topic>Gonadal Steroid Hormones - metabolism</topic><topic>growth substances</topic><topic>Humans</topic><topic>Lung Neoplasms - blood</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>parathyroid hormone receptor type 1</topic><topic>Parathyroid Hormone-Related Protein - blood</topic><topic>Parathyroid Hormone-Related Protein - metabolism</topic><topic>Pneumology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Sex Factors</topic><topic>steroid receptors</topic><topic>Tumor Burden</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montgrain, Philippe R.</creatorcontrib><creatorcontrib>Quintana, Rick</creatorcontrib><creatorcontrib>Rascon, Yvette</creatorcontrib><creatorcontrib>Burton, Douglas W.</creatorcontrib><creatorcontrib>Deftos, Leonard J.</creatorcontrib><creatorcontrib>Casillas, Andrea</creatorcontrib><creatorcontrib>Hastings, Randolph H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montgrain, Philippe R.</au><au>Quintana, Rick</au><au>Rascon, Yvette</au><au>Burton, Douglas W.</au><au>Deftos, Leonard J.</au><au>Casillas, Andrea</au><au>Hastings, Randolph H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parathyroid hormone‐related protein varies with sex and androgen status in nonsmall cell lung cancer</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2007-09-15</date><risdate>2007</risdate><volume>110</volume><issue>6</issue><spage>1313</spage><epage>1320</epage><pages>1313-1320</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND.
In nonsmall cell lung cancer, tumor parathyroid hormone‐related protein (PTHrP) expression predicts longer survival in women but not in men. To explain the sex‐dependent survival effect, the authors proposed that hormonal influences decrease PTHrP in men versus women, that PTHrP inhibits tumor growth, and that the effect is greater in women than in men. The objectives of this study were to compare lung carcinoma PTHrP expression and carcinoma growth in male and female mice and to determine whether gonadal steroids regulate PTHrP in lung cancer cells.
METHODS.
Tumor PTHrP content was measured by immunoassay, and tumor burden was assessed with multiple measures in BEN squamous cell orthotopic lung carcinomas in athymic mice. In addition, lung adenocarcinoma PTHrP messenger RNA (mRNA) values determined by microarray analyses were compared between men and women. Cultured lung cancer cells were assayed for PTHrP after treatment with estradiol or R1881, a synthetic androgen.
RESULTS.
Lung carcinomas contained approximately 3 times more PTHrP in female mice than in male mice. Similarly, levels of PTHrP mRNA were significantly greater in adenocarcinomas from patients who were women than from patients who were men. Male mice had greater tumor burden than female mice. Androgen treatment reduced PTHrP in 3 lung cancer lines. Estradiol had no effect. Testosterone treatment also reduced lung carcinoma PTHrP in female mice.
CONCLUSIONS.
Lung carcinomas in females expressed more PTHrP than in males possibly because of negative regulation by androgens in males. Female mice with higher tumor PTHrP content had significantly less tumor burden than male mice, supporting the hypothesis that PTHrP inhibits tumor growth. Cancer 2007. © 2007 American Cancer Society.
Parathyroid hormone‐related protein (PTHrP) was associated with prolonged survival in women, but not men, with nonsmall cell lung cancer. Androgen‐mediated decreases in PTHrP may be responsible for this sex dependence.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17676588</pmid><doi>10.1002/cncr.22922</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer, 2007-09, Vol.110 (6), p.1313-1320 |
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| subjects | Adenocarcinoma - metabolism Androgens - administration & dosage Androgens - blood Androgens - metabolism Animals biologic tumor marker Biological and medical sciences Blotting, Western Carcinoma, Large Cell - metabolism Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - metabolism Female Gene Expression Regulation, Neoplastic gonadal hormones Gonadal Steroid Hormones - metabolism growth substances Humans Lung Neoplasms - blood Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Medical sciences Mice Mice, Nude parathyroid hormone receptor type 1 Parathyroid Hormone-Related Protein - blood Parathyroid Hormone-Related Protein - metabolism Pneumology Reverse Transcriptase Polymerase Chain Reaction Sex Factors steroid receptors Tumor Burden Tumors Tumors of the respiratory system and mediastinum |
| title | Parathyroid hormone‐related protein varies with sex and androgen status in nonsmall cell lung cancer |
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