Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD)
Lysophosphatidic acid (LPA) is involved in a broad spectrum of biological activities, including wound healing and cancer metastasis. Autotaxin (ATX), originally isolated from a melanoma supernatant as a tumor cell motility-stimulating factor, has been shown to be molecularly identical to lysophospho...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2007-07, Vol.451 (1), p.47-56 |
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| container_title | Virchows Archiv : an international journal of pathology |
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| creator | MORI, Ken KITAYAMA, Joji AOKI, Junken KISHI, Yasuhiro SHIDA, Dai YAMASHITA, Hiroharu ARAI, Hiroyuki NAGAWA, Hirokazu |
| description | Lysophosphatidic acid (LPA) is involved in a broad spectrum of biological activities, including wound healing and cancer metastasis. Autotaxin (ATX), originally isolated from a melanoma supernatant as a tumor cell motility-stimulating factor, has been shown to be molecularly identical to lysophospholipase D (lysoPLD), which is the main enzyme in the production of LPA. Although ATX/lysoPLD is known to be widely expressed in normal human tissues, the exact distribution of ATX-producing cells has not been fully investigated. In this study, we evaluated ATX/lysoPLD expression by immunohistochemical staining using a rat anti-ATX mAb in the human gastrointestinal tract and found that submucosal mast cells (MC) highly expressed this enzyme. This was confirmed by immunofluorescent double staining using mAbs to tryptase and chymase. Then, we isolated MC from human gastric tissue by an immunomagnetic method using CD117-microbeads and showed that a subpopulation of CD203c-positive MC showed positive staining for intracellular ATX/lysoPLD on flowcytometry. This was confirmed by Western blotting of the isolated cells. Moreover, a significant level of ATX/lysoPLD release could be detected in the culture supernatants of human MC by Western blot analysis. Our data suggest that submucosal MC play significant roles in various aspects of pathophysiology in the gastrointestinal tract by locally providing bioactive LPA through the production of ATX/lysoPLD. |
| doi_str_mv | 10.1007/s00428-007-0425-4 |
| format | Article |
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Autotaxin (ATX), originally isolated from a melanoma supernatant as a tumor cell motility-stimulating factor, has been shown to be molecularly identical to lysophospholipase D (lysoPLD), which is the main enzyme in the production of LPA. Although ATX/lysoPLD is known to be widely expressed in normal human tissues, the exact distribution of ATX-producing cells has not been fully investigated. In this study, we evaluated ATX/lysoPLD expression by immunohistochemical staining using a rat anti-ATX mAb in the human gastrointestinal tract and found that submucosal mast cells (MC) highly expressed this enzyme. This was confirmed by immunofluorescent double staining using mAbs to tryptase and chymase. Then, we isolated MC from human gastric tissue by an immunomagnetic method using CD117-microbeads and showed that a subpopulation of CD203c-positive MC showed positive staining for intracellular ATX/lysoPLD on flowcytometry. This was confirmed by Western blotting of the isolated cells. Moreover, a significant level of ATX/lysoPLD release could be detected in the culture supernatants of human MC by Western blot analysis. Our data suggest that submucosal MC play significant roles in various aspects of pathophysiology in the gastrointestinal tract by locally providing bioactive LPA through the production of ATX/lysoPLD.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-007-0425-4</identifier><identifier>PMID: 17554559</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Biological and medical sciences ; Chymases - analysis ; Gastrointestinal tract ; Gastrointestinal Tract - cytology ; Gastrointestinal Tract - metabolism ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lysophospholipids - biosynthesis ; Mast Cells - classification ; Mast Cells - metabolism ; Medical research ; Medical sciences ; Melanoma ; Multienzyme Complexes - analysis ; Multienzyme Complexes - physiology ; Multienzyme Complexes - secretion ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Phosphodiesterase I - analysis ; Phosphodiesterase I - physiology ; Phosphodiesterase I - secretion ; Phosphoric Diester Hydrolases - analysis ; Phosphoric Diester Hydrolases - physiology ; Phosphoric Diester Hydrolases - secretion ; Proteins ; Pyrophosphatases - analysis ; Pyrophosphatases - physiology ; Pyrophosphatases - secretion ; Tryptases - analysis ; Wound Healing</subject><ispartof>Virchows Archiv : an international journal of pathology, 2007-07, Vol.451 (1), p.47-56</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-3abdacf57413af40aac971bd0c9fdd7ab22427b70146511f924841ff8cda42143</citedby><cites>FETCH-LOGICAL-c422t-3abdacf57413af40aac971bd0c9fdd7ab22427b70146511f924841ff8cda42143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18920368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17554559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MORI, Ken</creatorcontrib><creatorcontrib>KITAYAMA, Joji</creatorcontrib><creatorcontrib>AOKI, Junken</creatorcontrib><creatorcontrib>KISHI, Yasuhiro</creatorcontrib><creatorcontrib>SHIDA, Dai</creatorcontrib><creatorcontrib>YAMASHITA, Hiroharu</creatorcontrib><creatorcontrib>ARAI, Hiroyuki</creatorcontrib><creatorcontrib>NAGAWA, Hirokazu</creatorcontrib><title>Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD)</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><description>Lysophosphatidic acid (LPA) is involved in a broad spectrum of biological activities, including wound healing and cancer metastasis. Autotaxin (ATX), originally isolated from a melanoma supernatant as a tumor cell motility-stimulating factor, has been shown to be molecularly identical to lysophospholipase D (lysoPLD), which is the main enzyme in the production of LPA. Although ATX/lysoPLD is known to be widely expressed in normal human tissues, the exact distribution of ATX-producing cells has not been fully investigated. In this study, we evaluated ATX/lysoPLD expression by immunohistochemical staining using a rat anti-ATX mAb in the human gastrointestinal tract and found that submucosal mast cells (MC) highly expressed this enzyme. This was confirmed by immunofluorescent double staining using mAbs to tryptase and chymase. Then, we isolated MC from human gastric tissue by an immunomagnetic method using CD117-microbeads and showed that a subpopulation of CD203c-positive MC showed positive staining for intracellular ATX/lysoPLD on flowcytometry. This was confirmed by Western blotting of the isolated cells. Moreover, a significant level of ATX/lysoPLD release could be detected in the culture supernatants of human MC by Western blot analysis. Our data suggest that submucosal MC play significant roles in various aspects of pathophysiology in the gastrointestinal tract by locally providing bioactive LPA through the production of ATX/lysoPLD.</description><subject>Biological and medical sciences</subject><subject>Chymases - analysis</subject><subject>Gastrointestinal tract</subject><subject>Gastrointestinal Tract - cytology</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lysophospholipids - biosynthesis</subject><subject>Mast Cells - classification</subject><subject>Mast Cells - metabolism</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Melanoma</subject><subject>Multienzyme Complexes - analysis</subject><subject>Multienzyme Complexes - physiology</subject><subject>Multienzyme Complexes - secretion</subject><subject>Pathology. Cytology. Biochemistry. 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Academic</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MORI, Ken</au><au>KITAYAMA, Joji</au><au>AOKI, Junken</au><au>KISHI, Yasuhiro</au><au>SHIDA, Dai</au><au>YAMASHITA, Hiroharu</au><au>ARAI, Hiroyuki</au><au>NAGAWA, Hirokazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD)</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><addtitle>Virchows Arch</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>451</volume><issue>1</issue><spage>47</spage><epage>56</epage><pages>47-56</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>Lysophosphatidic acid (LPA) is involved in a broad spectrum of biological activities, including wound healing and cancer metastasis. Autotaxin (ATX), originally isolated from a melanoma supernatant as a tumor cell motility-stimulating factor, has been shown to be molecularly identical to lysophospholipase D (lysoPLD), which is the main enzyme in the production of LPA. Although ATX/lysoPLD is known to be widely expressed in normal human tissues, the exact distribution of ATX-producing cells has not been fully investigated. In this study, we evaluated ATX/lysoPLD expression by immunohistochemical staining using a rat anti-ATX mAb in the human gastrointestinal tract and found that submucosal mast cells (MC) highly expressed this enzyme. This was confirmed by immunofluorescent double staining using mAbs to tryptase and chymase. Then, we isolated MC from human gastric tissue by an immunomagnetic method using CD117-microbeads and showed that a subpopulation of CD203c-positive MC showed positive staining for intracellular ATX/lysoPLD on flowcytometry. This was confirmed by Western blotting of the isolated cells. Moreover, a significant level of ATX/lysoPLD release could be detected in the culture supernatants of human MC by Western blot analysis. Our data suggest that submucosal MC play significant roles in various aspects of pathophysiology in the gastrointestinal tract by locally providing bioactive LPA through the production of ATX/lysoPLD.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>17554559</pmid><doi>10.1007/s00428-007-0425-4</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0945-6317 |
| ispartof | Virchows Archiv : an international journal of pathology, 2007-07, Vol.451 (1), p.47-56 |
| issn | 0945-6317 1432-2307 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Biological and medical sciences Chymases - analysis Gastrointestinal tract Gastrointestinal Tract - cytology Gastrointestinal Tract - metabolism Humans Investigative techniques, diagnostic techniques (general aspects) Lysophospholipids - biosynthesis Mast Cells - classification Mast Cells - metabolism Medical research Medical sciences Melanoma Multienzyme Complexes - analysis Multienzyme Complexes - physiology Multienzyme Complexes - secretion Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phosphodiesterase I - analysis Phosphodiesterase I - physiology Phosphodiesterase I - secretion Phosphoric Diester Hydrolases - analysis Phosphoric Diester Hydrolases - physiology Phosphoric Diester Hydrolases - secretion Proteins Pyrophosphatases - analysis Pyrophosphatases - physiology Pyrophosphatases - secretion Tryptases - analysis Wound Healing |
| title | Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD) |
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