Cryptococcus gattii infection causing fulminant intracranial hypertension
Cryptococcus neoformans variety gattii (C. gattii) causes infection in predominantly immunocompetent individuals. The majority of cases present with headache due to meningitis and its natural history normally follows an indolent course. We report a fatal case of fulminant cryptococcaemia culminating...
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Veröffentlicht in: | British journal of anaesthesia : BJA 2007-10, Vol.99 (4), p.528-531 |
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description | Cryptococcus neoformans variety gattii (C. gattii) causes infection in predominantly immunocompetent individuals. The majority of cases present with headache due to meningitis and its natural history normally follows an indolent course. We report a fatal case of fulminant cryptococcaemia culminating in severe intracranial hypertension due to C. gattii. Such cases of fulminant disease are rare and highlight a number of important therapeutic and diagnostic considerations. We discuss the atypical nature of this patient’s illness, the major complications of C. gattii meningitis and the role of computed tomography (CT) in preventing serious sequelae from lumbar puncture. The management of intracranial hypertension (ICH) in critically ill patients is also reviewed. |
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The majority of cases present with headache due to meningitis and its natural history normally follows an indolent course. We report a fatal case of fulminant cryptococcaemia culminating in severe intracranial hypertension due to C. gattii. Such cases of fulminant disease are rare and highlight a number of important therapeutic and diagnostic considerations. We discuss the atypical nature of this patient’s illness, the major complications of C. gattii meningitis and the role of computed tomography (CT) in preventing serious sequelae from lumbar puncture. The management of intracranial hypertension (ICH) in critically ill patients is also reviewed.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/aem208</identifier><identifier>PMID: 17656353</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anesthesia ; Anesthesia. 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The majority of cases present with headache due to meningitis and its natural history normally follows an indolent course. We report a fatal case of fulminant cryptococcaemia culminating in severe intracranial hypertension due to C. gattii. Such cases of fulminant disease are rare and highlight a number of important therapeutic and diagnostic considerations. We discuss the atypical nature of this patient’s illness, the major complications of C. gattii meningitis and the role of computed tomography (CT) in preventing serious sequelae from lumbar puncture. The management of intracranial hypertension (ICH) in critically ill patients is also reviewed.</description><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>brain, intracranial pressure</subject><subject>coma, aetiology</subject><subject>Cryptococcus neoformans</subject><subject>cryptococcus, physiology</subject><subject>Fatal Outcome</subject><subject>Humans</subject><subject>intracranial hypertension</subject><subject>Intracranial Hypertension - diagnostic imaging</subject><subject>Intracranial Hypertension - microbiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>meningitis, cryptococcal</subject><subject>Meningitis, Cryptococcal - complications</subject><subject>Meningitis, Cryptococcal - diagnostic imaging</subject><subject>Middle Aged</subject><subject>Tomography, X-Ray Computed</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U2LFDEQBuAgLu64evEHSCPoQejdJN2dj6MMfiws7GU9h0x1Zc3QnbRJWph_b5YZGBDRUw55qoqql5A3jF4zqrub3d7eWJw5Vc_IhvWStUJK9pxsKKWypZrxS_Iy5z2lTHI9vCCXTIpBdEO3IbfbdFhKhAiw5ubRluJ944NDKD6GBuyafXhs3DrNPthQ6l9JFpIN3k7Nj8OCqWDI1b4iF85OGV-f3ivy_cvnh-239u7-6-32010LvepLK0YmcdQ7QLCql5w5t9OOuw6ooxSlgqEfhQDhnAJd9xuk5r3jwlEEpbruinw49l1S_LliLmb2GXCabMC4ZiMUHzou5H8hpwOnWvMK3_0B93FNoS5hmH6azjmt6OMRQYo5J3RmSX626WAYNU8xmBqDOcZQ8dtTx3U343imp7tX8P4EbAY7uXpP8PnsamZCCX12cV3-PbA_OqyX_-UxmQweA-DoU43SjNH_rew3iHOwHQ</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Bromilow, J.</creator><creator>Corcoran, T.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Cryptococcus gattii infection causing fulminant intracranial hypertension</title><author>Bromilow, J. ; Corcoran, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-6d17ed9bceca84721ffb9f2f3c0f00e78c54d66c6ff8c910957924f26f0ec8833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Anesthesia</topic><topic>Anesthesia. 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Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>brain, intracranial pressure</topic><topic>coma, aetiology</topic><topic>Cryptococcus neoformans</topic><topic>cryptococcus, physiology</topic><topic>Fatal Outcome</topic><topic>Humans</topic><topic>intracranial hypertension</topic><topic>Intracranial Hypertension - diagnostic imaging</topic><topic>Intracranial Hypertension - microbiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>meningitis, cryptococcal</topic><topic>Meningitis, Cryptococcal - complications</topic><topic>Meningitis, Cryptococcal - diagnostic imaging</topic><topic>Middle Aged</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bromilow, J.</creatorcontrib><creatorcontrib>Corcoran, T.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bromilow, J.</au><au>Corcoran, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cryptococcus gattii infection causing fulminant intracranial hypertension</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><stitle>Br J Anaesth</stitle><addtitle>Br J Anaesth</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>99</volume><issue>4</issue><spage>528</spage><epage>531</epage><pages>528-531</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Cryptococcus neoformans variety gattii (C. gattii) causes infection in predominantly immunocompetent individuals. The majority of cases present with headache due to meningitis and its natural history normally follows an indolent course. We report a fatal case of fulminant cryptococcaemia culminating in severe intracranial hypertension due to C. gattii. Such cases of fulminant disease are rare and highlight a number of important therapeutic and diagnostic considerations. We discuss the atypical nature of this patient’s illness, the major complications of C. gattii meningitis and the role of computed tomography (CT) in preventing serious sequelae from lumbar puncture. The management of intracranial hypertension (ICH) in critically ill patients is also reviewed.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17656353</pmid><doi>10.1093/bja/aem208</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences brain, intracranial pressure coma, aetiology Cryptococcus neoformans cryptococcus, physiology Fatal Outcome Humans intracranial hypertension Intracranial Hypertension - diagnostic imaging Intracranial Hypertension - microbiology Male Medical sciences meningitis, cryptococcal Meningitis, Cryptococcal - complications Meningitis, Cryptococcal - diagnostic imaging Middle Aged Tomography, X-Ray Computed |
title | Cryptococcus gattii infection causing fulminant intracranial hypertension |
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