Cholinesterase Inhibiting and Antiplasmodial Steroidal Alkaloids from Sarcococca hookeriana
Bioguided phytochemical investigation of Sarcococca hookeriana with respect to the cholinesterase enzyme inhibitory assay yielded two new pregnane-type steriodal alkaloids hookerianamide H (1) and hookerianamide I (2), along with three known alkaloids Na-methylepipachysamine D (3), sarcovagine C (4)...
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| Veröffentlicht in: | Chemical & Pharmaceutical Bulletin 2007/09/01, Vol.55(9), pp.1397-1401 |
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| container_title | Chemical & Pharmaceutical Bulletin |
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| creator | Devkota, Krishna Prasad Lenta, Bruno Ndjakou Choudhary, Muhammad Iqbal Naz, Qamar Fekam, Fabrice Boyom Rosenthal, Philip Joseph Sewald, Norbert |
| description | Bioguided phytochemical investigation of Sarcococca hookeriana with respect to the cholinesterase enzyme inhibitory assay yielded two new pregnane-type steriodal alkaloids hookerianamide H (1) and hookerianamide I (2), along with three known alkaloids Na-methylepipachysamine D (3), sarcovagine C (4) and dictyophlebine (5). Their structures were determined with the aid of extensive spectroscopic analysis. All compounds showed good inhibitory activities against the enzymes acetylcholinesterase (IC50 2.9—34.1 μM) and butyrylcholinesterase (IC50 0.3—3.6 μM). These compounds also showed moderate antiplasmodial activity (IC50 2.4—10.3 μM) against the Plasmodium falciparum chloroquine resistant W2 strain. |
| doi_str_mv | 10.1248/cpb.55.1397 |
| format | Article |
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Their structures were determined with the aid of extensive spectroscopic analysis. All compounds showed good inhibitory activities against the enzymes acetylcholinesterase (IC50 2.9—34.1 μM) and butyrylcholinesterase (IC50 0.3—3.6 μM). These compounds also showed moderate antiplasmodial activity (IC50 2.4—10.3 μM) against the Plasmodium falciparum chloroquine resistant W2 strain.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.55.1397</identifier><identifier>PMID: 17827771</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Alkaloids - isolation & purification ; Alkaloids - pharmacology ; Alzheimer's disease ; Animals ; Antimalarials ; antiplasmodial ; Butyrylcholinesterase - metabolism ; Buxaceae - chemistry ; cholinesterase inhibition ; Cholinesterase Inhibitors ; Drug Resistance ; Magnetic Resonance Spectroscopy ; Plasmodium falciparum - drug effects ; Pregnanes - isolation & purification ; Pregnanes - pharmacology ; Sarcococca hookeriana ; Spectrophotometry, Infrared ; Spectrophotometry, Ultraviolet ; steroidal alkaloid ; Steroids - isolation & purification ; Steroids - pharmacology</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2007/09/01, Vol.55(9), pp.1397-1401</ispartof><rights>2007 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c688t-49bcba52ec6786e17f13cbd0d8827e5d1e2a538064bc2f1d893d6e91ed5a57fd3</citedby><cites>FETCH-LOGICAL-c688t-49bcba52ec6786e17f13cbd0d8827e5d1e2a538064bc2f1d893d6e91ed5a57fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17827771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Devkota, Krishna Prasad</creatorcontrib><creatorcontrib>Lenta, Bruno Ndjakou</creatorcontrib><creatorcontrib>Choudhary, Muhammad Iqbal</creatorcontrib><creatorcontrib>Naz, Qamar</creatorcontrib><creatorcontrib>Fekam, Fabrice Boyom</creatorcontrib><creatorcontrib>Rosenthal, Philip Joseph</creatorcontrib><creatorcontrib>Sewald, Norbert</creatorcontrib><creatorcontrib>Pokhara Campus</creatorcontrib><creatorcontrib>fDivision oflnfectious Diseases</creatorcontrib><creatorcontrib>bInstitute of Forestry</creatorcontrib><creatorcontrib>aDepartment of Chemistry</creatorcontrib><creatorcontrib>Department of Medicine</creatorcontrib><creatorcontrib>Tribhuvan University</creatorcontrib><creatorcontrib>University of Karachi</creatorcontrib><creatorcontrib>Faculty of Science</creatorcontrib><creatorcontrib>cHigher Teacher's Training College</creatorcontrib><creatorcontrib>dH.E.J Research Institute of Chemistry</creatorcontrib><creatorcontrib>University of California</creatorcontrib><creatorcontrib>Bielefeld University</creatorcontrib><creatorcontrib>Organic and Bioorganic Chemistry</creatorcontrib><creatorcontrib>International Center for Chemical and Biological Sciences</creatorcontrib><creatorcontrib>eDepartment of Biochemistry</creatorcontrib><creatorcontrib>University of Yaounde I</creatorcontrib><title>Cholinesterase Inhibiting and Antiplasmodial Steroidal Alkaloids from Sarcococca hookeriana</title><title>Chemical & Pharmaceutical Bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Bioguided phytochemical investigation of Sarcococca hookeriana with respect to the cholinesterase enzyme inhibitory assay yielded two new pregnane-type steriodal alkaloids hookerianamide H (1) and hookerianamide I (2), along with three known alkaloids Na-methylepipachysamine D (3), sarcovagine C (4) and dictyophlebine (5). Their structures were determined with the aid of extensive spectroscopic analysis. All compounds showed good inhibitory activities against the enzymes acetylcholinesterase (IC50 2.9—34.1 μM) and butyrylcholinesterase (IC50 0.3—3.6 μM). These compounds also showed moderate antiplasmodial activity (IC50 2.4—10.3 μM) against the Plasmodium falciparum chloroquine resistant W2 strain.</description><subject>Alkaloids - isolation & purification</subject><subject>Alkaloids - pharmacology</subject><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Antimalarials</subject><subject>antiplasmodial</subject><subject>Butyrylcholinesterase - metabolism</subject><subject>Buxaceae - chemistry</subject><subject>cholinesterase inhibition</subject><subject>Cholinesterase Inhibitors</subject><subject>Drug Resistance</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Plasmodium falciparum - drug effects</subject><subject>Pregnanes - isolation & purification</subject><subject>Pregnanes - pharmacology</subject><subject>Sarcococca hookeriana</subject><subject>Spectrophotometry, Infrared</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>steroidal alkaloid</subject><subject>Steroids - isolation & purification</subject><subject>Steroids - pharmacology</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEGLFDEQhYMo7rh68i4NghfpsZJ0Oumbw-DqwoKH1ZOHkE6qdzLbnYxJz8F_b2Z73AUJJAX15dWrR8hbCmvKGvXJHvq1EGvKO_mMrChvZC0Y48_JCgC6mvGWX5BXOe8BmADJX5ILKhWTUtIV-bXdxdEHzDMmk7G6Djvf-9mHu8oEV23C7A-jyVN03ozVbaGid6XajPdmLGWuhhSn6tYkG8uxptrFeI_Jm2BekxeDGTO-Ob-X5OfVlx_bb_XN96_X281NbVul5rrpetsbwdC2UrVI5UC57R04VUyicBSZEVxB2_SWDdSpjrsWO4pOGCEHxy_Jh0X3kOLvY1lFTz5bHEcTMB6zbhUTnKqmgO__A_fxmELxpmnTQgMNlaJQHxfKpphzwkEfkp9M-qMp6FPiuiSuhdCnxAv97qx57Cd0T-w54gJcLUDpeltCC6e8nybbLO0OJ68ZgNQAQkCngfEH-eILqOSCC1WEPi9C-zybO3ycZNLs7Yj_XHXL9fD7sbUzSWPgfwGjraox</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Devkota, Krishna Prasad</creator><creator>Lenta, Bruno Ndjakou</creator><creator>Choudhary, Muhammad Iqbal</creator><creator>Naz, Qamar</creator><creator>Fekam, Fabrice Boyom</creator><creator>Rosenthal, Philip Joseph</creator><creator>Sewald, Norbert</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Cholinesterase Inhibiting and Antiplasmodial Steroidal Alkaloids from Sarcococca hookeriana</title><author>Devkota, Krishna Prasad ; 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Pharm. Bull.</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>55</volume><issue>9</issue><spage>1397</spage><epage>1401</epage><pages>1397-1401</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Bioguided phytochemical investigation of Sarcococca hookeriana with respect to the cholinesterase enzyme inhibitory assay yielded two new pregnane-type steriodal alkaloids hookerianamide H (1) and hookerianamide I (2), along with three known alkaloids Na-methylepipachysamine D (3), sarcovagine C (4) and dictyophlebine (5). Their structures were determined with the aid of extensive spectroscopic analysis. All compounds showed good inhibitory activities against the enzymes acetylcholinesterase (IC50 2.9—34.1 μM) and butyrylcholinesterase (IC50 0.3—3.6 μM). These compounds also showed moderate antiplasmodial activity (IC50 2.4—10.3 μM) against the Plasmodium falciparum chloroquine resistant W2 strain.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>17827771</pmid><doi>10.1248/cpb.55.1397</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Alkaloids - isolation & purification Alkaloids - pharmacology Alzheimer's disease Animals Antimalarials antiplasmodial Butyrylcholinesterase - metabolism Buxaceae - chemistry cholinesterase inhibition Cholinesterase Inhibitors Drug Resistance Magnetic Resonance Spectroscopy Plasmodium falciparum - drug effects Pregnanes - isolation & purification Pregnanes - pharmacology Sarcococca hookeriana Spectrophotometry, Infrared Spectrophotometry, Ultraviolet steroidal alkaloid Steroids - isolation & purification Steroids - pharmacology |
| title | Cholinesterase Inhibiting and Antiplasmodial Steroidal Alkaloids from Sarcococca hookeriana |
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