Age-related BM-MNC dysfunction hampers neovascularization

Although ischemia-induced neovascularization is reportedly impaired with aging, the effect of aged-bone marrow mononuclear cells (BM-MNCs) on neovascularization has not been investigated. The neovascularization capacity of BM-MNCs obtained from 8-week-old mice (young) was compared to those obtained...

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Veröffentlicht in:	Mechanisms of ageing and development 2007-09, Vol.128 (9), p.511-516
Hauptverfasser:	Sugihara, Shinobu, Yamamoto, Yasutaka, Matsuura, Takashi, Narazaki, Genta, Yamasaki, Akira, Igawa, Go, Matsubara, Koichi, Miake, Junichiro, Igawa, Osamu, Shigemasa, Chiaki, Hisatome, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Age Factors Aging Animals Antigens, CD - analysis Antigens, CD34 - analysis Biological and medical sciences Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Bone marrow mononuclear cells Bone Marrow Transplantation Cell Movement Development. Metamorphosis. Moult. Ageing Disease Models, Animal Endothelial Cells - metabolism Fundamental and applied biological sciences. Psychology Glycoproteins - analysis Hindlimb Ischemia Ischemia - metabolism Ischemia - physiopathology Ischemia - surgery Male Mice Mice, Inbred C57BL Muscle, Skeletal - blood supply Muscle, Skeletal - metabolism Muscle, Skeletal - surgery Neovascularization Neovascularization, Physiologic Peptides - analysis Stem Cells - metabolism Time Factors Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - analysis VEGF Vertebrates: anatomy and physiology, studies on body, several organs or systems
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