Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high‐risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation
BACKGROUND. Invasive aspergillosis (IA) is a leading cause of death in patients with leukemia and those who have undergone hematopoietic stem cell transplantation. Laboratory studies have demonstrated that iron is essential for Aspergillus growth and virulence. METHODS. In the current study, the aut...
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| Veröffentlicht in: | Cancer 2007-09, Vol.110 (6), p.1303-1306 |
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| container_title | Cancer |
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| creator | Kontoyiannis, Dimitrios P. Chamilos, Georgios Lewis, Russell E. Giralt, Sergio Cortes, Jorge Raad, Issam I. Manning, John T. Han, Xin |
| description | BACKGROUND.
Invasive aspergillosis (IA) is a leading cause of death in patients with leukemia and those who have undergone hematopoietic stem cell transplantation. Laboratory studies have demonstrated that iron is essential for Aspergillus growth and virulence.
METHODS.
In the current study, the authors retrospectively evaluated the bone marrow iron stores (BMIS) in patients with leukemia as well as recipients of allogeneic hematopoietic stem cell transplantation with IA (n = 33) and those without fungal infections (n = 33). The first available bone marrow biopsy specimens prior to the IA diagnosis or date of hospitalization (control group) were assessed in a blinded fashion using a standardized scoring system (0–4). Both groups were comparable with regard to clinical characteristics and classic risk factors for IA.
RESULTS.
The majority of patients with IA (70%) were found to have increased BMIS (score ≥3) compared with the control patients (16%) (P < .0001). Increased BMIS was found to be an independent risk factor for IA on multivariate analysis (P < .0001).
CONCLUSIONS.
The prospective validation of BMIS for risk stratification in patients with leukemia or those who undergo allogeneic hematopoietic stem cell transplantation is needed. Cancer 2007. © 2007 American Cancer Society.
The authors retrospectively evaluated the bone marrow iron stores (BMIS) in 33 patients with hematologic malignancies and invasive aspergillosis (IA) compared with 33 contemporaneous, high‐risk patients without fungal infections. The majority of patients with IA (70%) had increased BMIS compared with controls (16%), and increased BMIS was found to be an independent risk factor for IA using multivariate analysis (P < .0001). |
| doi_str_mv | 10.1002/cncr.22909 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68251394</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68251394</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3939-4c7facfc1039a9c5fb48657c8285b9b94a729840416116c6245fae549b6c1ea13</originalsourceid><addsrcrecordid>eNp9kU2O1DAQhS0EYpqBDQdA3sACKYOdOD9eotYAI41AQiCxiyruStqQ2MHlntbsOAKX4wKcBGfS0uxY2FbJ36tn12PsuRQXUoj8jXEmXOS5FvoB20ih60xIlT9kGyFEk5Wq-HbGnhB9T2Wdl8VjdibrSqpCFBv25yqJEQh3vPMO-QQh-CO3wTtO0QckbomD49btcMa0uciDpR-8B5PueZ-WdTdA9gY50IxhsOPoKams4zNEmxTEjzbu-d4O-7-_ft_J9zhB9KMfrEmmox0cOGNx8drxgMbOq9D3HFK_AR0mclXN3mJMFUWcuMFx5DGAo3kEF5Ohd0_Zox5Gwmen85x9fXf5Zfshu_70_mr79jozhS50pkydftEbKQoN2pR9p5qqrE2TN2WnO62gznWjhJKVlJWpclX2gKXSXWUkgizO2au17xz8zwNSbCdLy4PAoT9QWzV5KQutEvh6BU3wRAH7dg42zfq2laJdQmyXENu7EBP84tT10E24u0dPqSXg5QkAMjD2YRkd3XNaqLLRInFy5Y52xNv_WLbbj9vPq_k_TlO8Lw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68251394</pqid></control><display><type>article</type><title>Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high‐risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Kontoyiannis, Dimitrios P. ; Chamilos, Georgios ; Lewis, Russell E. ; Giralt, Sergio ; Cortes, Jorge ; Raad, Issam I. ; Manning, John T. ; Han, Xin</creator><creatorcontrib>Kontoyiannis, Dimitrios P. ; Chamilos, Georgios ; Lewis, Russell E. ; Giralt, Sergio ; Cortes, Jorge ; Raad, Issam I. ; Manning, John T. ; Han, Xin</creatorcontrib><description>BACKGROUND.
Invasive aspergillosis (IA) is a leading cause of death in patients with leukemia and those who have undergone hematopoietic stem cell transplantation. Laboratory studies have demonstrated that iron is essential for Aspergillus growth and virulence.
METHODS.
In the current study, the authors retrospectively evaluated the bone marrow iron stores (BMIS) in patients with leukemia as well as recipients of allogeneic hematopoietic stem cell transplantation with IA (n = 33) and those without fungal infections (n = 33). The first available bone marrow biopsy specimens prior to the IA diagnosis or date of hospitalization (control group) were assessed in a blinded fashion using a standardized scoring system (0–4). Both groups were comparable with regard to clinical characteristics and classic risk factors for IA.
RESULTS.
The majority of patients with IA (70%) were found to have increased BMIS (score ≥3) compared with the control patients (16%) (P < .0001). Increased BMIS was found to be an independent risk factor for IA on multivariate analysis (P < .0001).
CONCLUSIONS.
The prospective validation of BMIS for risk stratification in patients with leukemia or those who undergo allogeneic hematopoietic stem cell transplantation is needed. Cancer 2007. © 2007 American Cancer Society.
The authors retrospectively evaluated the bone marrow iron stores (BMIS) in 33 patients with hematologic malignancies and invasive aspergillosis (IA) compared with 33 contemporaneous, high‐risk patients without fungal infections. The majority of patients with IA (70%) had increased BMIS compared with controls (16%), and increased BMIS was found to be an independent risk factor for IA using multivariate analysis (P < .0001).</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.22909</identifier><identifier>PMID: 17614303</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Analysis of Variance ; aspergillosis ; Aspergillosis - etiology ; Biological and medical sciences ; Biopsy ; bone marrow ; Bone Marrow - metabolism ; Child ; Child, Preschool ; Female ; Hematologic Neoplasms - metabolism ; Hematologic Neoplasms - surgery ; Hematopoietic Stem Cell Transplantation - adverse effects ; Human mycoses ; Humans ; Infectious diseases ; iron ; Iron - metabolism ; leukemia ; Male ; Medical Records ; Medical sciences ; Middle Aged ; Miscellaneous mycoses ; Mycoses ; Retrospective Studies ; Risk Factors ; Transplantation, Homologous ; Tumors</subject><ispartof>Cancer, 2007-09, Vol.110 (6), p.1303-1306</ispartof><rights>Copyright © 2007 American Cancer Society</rights><rights>2007 INIST-CNRS</rights><rights>(c) 2007 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3939-4c7facfc1039a9c5fb48657c8285b9b94a729840416116c6245fae549b6c1ea13</citedby><cites>FETCH-LOGICAL-c3939-4c7facfc1039a9c5fb48657c8285b9b94a729840416116c6245fae549b6c1ea13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.22909$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.22909$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19045890$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17614303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kontoyiannis, Dimitrios P.</creatorcontrib><creatorcontrib>Chamilos, Georgios</creatorcontrib><creatorcontrib>Lewis, Russell E.</creatorcontrib><creatorcontrib>Giralt, Sergio</creatorcontrib><creatorcontrib>Cortes, Jorge</creatorcontrib><creatorcontrib>Raad, Issam I.</creatorcontrib><creatorcontrib>Manning, John T.</creatorcontrib><creatorcontrib>Han, Xin</creatorcontrib><title>Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high‐risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND.
Invasive aspergillosis (IA) is a leading cause of death in patients with leukemia and those who have undergone hematopoietic stem cell transplantation. Laboratory studies have demonstrated that iron is essential for Aspergillus growth and virulence.
METHODS.
In the current study, the authors retrospectively evaluated the bone marrow iron stores (BMIS) in patients with leukemia as well as recipients of allogeneic hematopoietic stem cell transplantation with IA (n = 33) and those without fungal infections (n = 33). The first available bone marrow biopsy specimens prior to the IA diagnosis or date of hospitalization (control group) were assessed in a blinded fashion using a standardized scoring system (0–4). Both groups were comparable with regard to clinical characteristics and classic risk factors for IA.
RESULTS.
The majority of patients with IA (70%) were found to have increased BMIS (score ≥3) compared with the control patients (16%) (P < .0001). Increased BMIS was found to be an independent risk factor for IA on multivariate analysis (P < .0001).
CONCLUSIONS.
The prospective validation of BMIS for risk stratification in patients with leukemia or those who undergo allogeneic hematopoietic stem cell transplantation is needed. Cancer 2007. © 2007 American Cancer Society.
The authors retrospectively evaluated the bone marrow iron stores (BMIS) in 33 patients with hematologic malignancies and invasive aspergillosis (IA) compared with 33 contemporaneous, high‐risk patients without fungal infections. The majority of patients with IA (70%) had increased BMIS compared with controls (16%), and increased BMIS was found to be an independent risk factor for IA using multivariate analysis (P < .0001).</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>aspergillosis</subject><subject>Aspergillosis - etiology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>bone marrow</subject><subject>Bone Marrow - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Hematologic Neoplasms - metabolism</subject><subject>Hematologic Neoplasms - surgery</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Human mycoses</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>iron</subject><subject>Iron - metabolism</subject><subject>leukemia</subject><subject>Male</subject><subject>Medical Records</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous mycoses</subject><subject>Mycoses</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Transplantation, Homologous</subject><subject>Tumors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2O1DAQhS0EYpqBDQdA3sACKYOdOD9eotYAI41AQiCxiyruStqQ2MHlntbsOAKX4wKcBGfS0uxY2FbJ36tn12PsuRQXUoj8jXEmXOS5FvoB20ih60xIlT9kGyFEk5Wq-HbGnhB9T2Wdl8VjdibrSqpCFBv25yqJEQh3vPMO-QQh-CO3wTtO0QckbomD49btcMa0uciDpR-8B5PueZ-WdTdA9gY50IxhsOPoKams4zNEmxTEjzbu-d4O-7-_ft_J9zhB9KMfrEmmox0cOGNx8drxgMbOq9D3HFK_AR0mclXN3mJMFUWcuMFx5DGAo3kEF5Ohd0_Zox5Gwmen85x9fXf5Zfshu_70_mr79jozhS50pkydftEbKQoN2pR9p5qqrE2TN2WnO62gznWjhJKVlJWpclX2gKXSXWUkgizO2au17xz8zwNSbCdLy4PAoT9QWzV5KQutEvh6BU3wRAH7dg42zfq2laJdQmyXENu7EBP84tT10E24u0dPqSXg5QkAMjD2YRkd3XNaqLLRInFy5Y52xNv_WLbbj9vPq_k_TlO8Lw</recordid><startdate>20070915</startdate><enddate>20070915</enddate><creator>Kontoyiannis, Dimitrios P.</creator><creator>Chamilos, Georgios</creator><creator>Lewis, Russell E.</creator><creator>Giralt, Sergio</creator><creator>Cortes, Jorge</creator><creator>Raad, Issam I.</creator><creator>Manning, John T.</creator><creator>Han, Xin</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070915</creationdate><title>Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high‐risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation</title><author>Kontoyiannis, Dimitrios P. ; Chamilos, Georgios ; Lewis, Russell E. ; Giralt, Sergio ; Cortes, Jorge ; Raad, Issam I. ; Manning, John T. ; Han, Xin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3939-4c7facfc1039a9c5fb48657c8285b9b94a729840416116c6245fae549b6c1ea13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>aspergillosis</topic><topic>Aspergillosis - etiology</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>bone marrow</topic><topic>Bone Marrow - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Hematologic Neoplasms - metabolism</topic><topic>Hematologic Neoplasms - surgery</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Human mycoses</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>iron</topic><topic>Iron - metabolism</topic><topic>leukemia</topic><topic>Male</topic><topic>Medical Records</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous mycoses</topic><topic>Mycoses</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Transplantation, Homologous</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kontoyiannis, Dimitrios P.</creatorcontrib><creatorcontrib>Chamilos, Georgios</creatorcontrib><creatorcontrib>Lewis, Russell E.</creatorcontrib><creatorcontrib>Giralt, Sergio</creatorcontrib><creatorcontrib>Cortes, Jorge</creatorcontrib><creatorcontrib>Raad, Issam I.</creatorcontrib><creatorcontrib>Manning, John T.</creatorcontrib><creatorcontrib>Han, Xin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kontoyiannis, Dimitrios P.</au><au>Chamilos, Georgios</au><au>Lewis, Russell E.</au><au>Giralt, Sergio</au><au>Cortes, Jorge</au><au>Raad, Issam I.</au><au>Manning, John T.</au><au>Han, Xin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high‐risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2007-09-15</date><risdate>2007</risdate><volume>110</volume><issue>6</issue><spage>1303</spage><epage>1306</epage><pages>1303-1306</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND.
Invasive aspergillosis (IA) is a leading cause of death in patients with leukemia and those who have undergone hematopoietic stem cell transplantation. Laboratory studies have demonstrated that iron is essential for Aspergillus growth and virulence.
METHODS.
In the current study, the authors retrospectively evaluated the bone marrow iron stores (BMIS) in patients with leukemia as well as recipients of allogeneic hematopoietic stem cell transplantation with IA (n = 33) and those without fungal infections (n = 33). The first available bone marrow biopsy specimens prior to the IA diagnosis or date of hospitalization (control group) were assessed in a blinded fashion using a standardized scoring system (0–4). Both groups were comparable with regard to clinical characteristics and classic risk factors for IA.
RESULTS.
The majority of patients with IA (70%) were found to have increased BMIS (score ≥3) compared with the control patients (16%) (P < .0001). Increased BMIS was found to be an independent risk factor for IA on multivariate analysis (P < .0001).
CONCLUSIONS.
The prospective validation of BMIS for risk stratification in patients with leukemia or those who undergo allogeneic hematopoietic stem cell transplantation is needed. Cancer 2007. © 2007 American Cancer Society.
The authors retrospectively evaluated the bone marrow iron stores (BMIS) in 33 patients with hematologic malignancies and invasive aspergillosis (IA) compared with 33 contemporaneous, high‐risk patients without fungal infections. The majority of patients with IA (70%) had increased BMIS compared with controls (16%), and increased BMIS was found to be an independent risk factor for IA using multivariate analysis (P < .0001).</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17614303</pmid><doi>10.1002/cncr.22909</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Analysis of Variance aspergillosis Aspergillosis - etiology Biological and medical sciences Biopsy bone marrow Bone Marrow - metabolism Child Child, Preschool Female Hematologic Neoplasms - metabolism Hematologic Neoplasms - surgery Hematopoietic Stem Cell Transplantation - adverse effects Human mycoses Humans Infectious diseases iron Iron - metabolism leukemia Male Medical Records Medical sciences Middle Aged Miscellaneous mycoses Mycoses Retrospective Studies Risk Factors Transplantation, Homologous Tumors |
| title | Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high‐risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation |
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