Quantitation Assay for Absorption and First-Pass Metabolism of Emodin in Isolated Rat Small Intestine Using Liquid Chromatography-Tandem Mass Spectrometry

Emodin has numerous biochemical and pharmacological activities, though information about its intestinal absorption and first-pass metabolism is scarce. The purpose of this study was to evaluate intestinal absorption and metabolism of luminally administered emodin in an isolated rat small intestine u...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2007/09/01, Vol.30(9), pp.1628-1633
Hauptverfasser:	Teng, Zeng-Hui, Zhou, Si-Yuan, Yang, Run-Tao, Liu, Xin-You, Liu, Ren-Wang, Yang, Xi, Zhang, Bang-Le, Yang, Jing-Yue, Cao, Da-Yong, Mei, Qi-Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption Animals Biological Availability Cathartics - metabolism Chromatography, Liquid emodin Emodin - metabolism first-pass metabolism Glucuronides - metabolism In Vitro Techniques Intestinal Absorption Intestine, Small - metabolism LC/MS/MS Male Perfusion Rats Rats, Sprague-Dawley small intestine Splanchnic Circulation - physiology Sulfates - metabolism Tandem Mass Spectrometry
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