Hepatocyte Growth Factor Fusion Protein Having Collagen-Binding Activity (CBD-HGF) Accelerates Re-endothelialization and Intimal Hyperplasia in Balloon-injured Rat Carotid Artery

Aim: Hepatocyte growth factor (HGF) is known to stimulate endothelial cell proliferation. However, re-endothelialization is not enhanced when the native protein is administered to the injured artery, probably due to the short half-life of HGF at the site of injury. Therefore, the effects of an HGF f...

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Veröffentlicht in:	Journal of Atherosclerosis and Thrombosis 2007, Vol.14(4), pp.185-191
Hauptverfasser:	Ohkawara, Nana, Ueda, Hiroki, Shinozaki, Shohei, Kitajima, Takashi, Ito, Yoshihiro, Asaoka, Hiroshi, Kawakami, Akio, Kaneko, Eiji, Shimokado, Kentaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - cytology c-Met Carotid Artery Injuries - drug therapy Carotid Artery Injuries - pathology Catheterization - adverse effects Cell Division - drug effects Cells, Cultured Collagen - metabolism Drug delivery system Drug Delivery Systems Endothelial cells Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Hepatocyte Growth Factor - metabolism Hepatocyte Growth Factor - pharmacology Hyperplasia Male Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology Rats Rats, Sprague-Dawley Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Smooth muscle cells Tunica Intima - drug effects Tunica Intima - pathology
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