Clinical study on lung disease caused by non-tuberculous mycobacteriosis in the elderly
Aim: This study was done to clarify the characteristics of elderly patients with nontuberculous mycobacteriosis. Methods: We investigated the clinical features of 10 patients at an advanced age who had been given diagnosis of nontuberculous mycobacteriosis. Results: Mycobacterium avium intracellular...
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| Veröffentlicht in: | Nihon Rōnen Igakkai zasshi 2007, Vol.44(4), pp.503-506 |
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| container_title | Nihon Rōnen Igakkai zasshi |
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| creator | Sugihara, Eiichiro Dambara, Takashi Aiba, Miyoji Fukuda, Yukiko Nakajima, Naoya Inui, Akihiro Matsumoto, Naomi Hada, Naoko Katayama, Akiko Naito, Toshio Isonuma, Hiroshi Hayashida, Yasuo |
| description | Aim: This study was done to clarify the characteristics of elderly patients with nontuberculous mycobacteriosis. Methods: We investigated the clinical features of 10 patients at an advanced age who had been given diagnosis of nontuberculous mycobacteriosis. Results: Mycobacterium avium intracellulare complex (MAC) were detected in all cases. The age of the patients ranged from 65 to 92. Four cases had underlying respiratory diseases (old pulmonary tuberculosis in 3 cases, pulmonary emphysema in 1 case, bronchiectasia in 1 case). Six cases suffered from dementia. The symptoms were relatively nonspecific, such as low grade fever, fatigue, appetite loss in almost all cases in this study. On computed tomography (CT) scans of the chest, mainly small nodular infiltrates were seen. MAC was detected in clinical samples such as sputum, gastric juice and bronchial lavage. The examination of gastric juice was performed in 6 out of the 10 cases. Gastric juice samples were smear-positive for acid-fast bacilli in 5 of 6, and culture-positive for MAC in 5 of 6. The detection of MAC in gastric juice samples was higher than that in sputum samples on admission. Conclusion: Gastric juice might be useful to differentiate infection from casual isolation of MAC in elderly patients. |
| doi_str_mv | 10.3143/geriatrics.44.503 |
| format | Article |
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Methods: We investigated the clinical features of 10 patients at an advanced age who had been given diagnosis of nontuberculous mycobacteriosis. Results: Mycobacterium avium intracellulare complex (MAC) were detected in all cases. The age of the patients ranged from 65 to 92. Four cases had underlying respiratory diseases (old pulmonary tuberculosis in 3 cases, pulmonary emphysema in 1 case, bronchiectasia in 1 case). Six cases suffered from dementia. The symptoms were relatively nonspecific, such as low grade fever, fatigue, appetite loss in almost all cases in this study. On computed tomography (CT) scans of the chest, mainly small nodular infiltrates were seen. MAC was detected in clinical samples such as sputum, gastric juice and bronchial lavage. The examination of gastric juice was performed in 6 out of the 10 cases. Gastric juice samples were smear-positive for acid-fast bacilli in 5 of 6, and culture-positive for MAC in 5 of 6. The detection of MAC in gastric juice samples was higher than that in sputum samples on admission. Conclusion: Gastric juice might be useful to differentiate infection from casual isolation of MAC in elderly patients.</description><identifier>ISSN: 0300-9173</identifier><identifier>DOI: 10.3143/geriatrics.44.503</identifier><identifier>PMID: 17827810</identifier><language>jpn</language><publisher>Japan: The Japan Geriatrics Society</publisher><subject>Aged ; Aged, 80 and over ; Elderly persons ; Female ; Gastric aspirate ; Humans ; Male ; Mycobacterium avium-intracellulare Infection - diagnosis ; Nontuberculous mycobacteriosis ; Tuberculosis, Pulmonary - diagnosis</subject><ispartof>Nippon Ronen Igakkai Zasshi. 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Methods: We investigated the clinical features of 10 patients at an advanced age who had been given diagnosis of nontuberculous mycobacteriosis. Results: Mycobacterium avium intracellulare complex (MAC) were detected in all cases. The age of the patients ranged from 65 to 92. Four cases had underlying respiratory diseases (old pulmonary tuberculosis in 3 cases, pulmonary emphysema in 1 case, bronchiectasia in 1 case). Six cases suffered from dementia. The symptoms were relatively nonspecific, such as low grade fever, fatigue, appetite loss in almost all cases in this study. On computed tomography (CT) scans of the chest, mainly small nodular infiltrates were seen. MAC was detected in clinical samples such as sputum, gastric juice and bronchial lavage. The examination of gastric juice was performed in 6 out of the 10 cases. Gastric juice samples were smear-positive for acid-fast bacilli in 5 of 6, and culture-positive for MAC in 5 of 6. The detection of MAC in gastric juice samples was higher than that in sputum samples on admission. Conclusion: Gastric juice might be useful to differentiate infection from casual isolation of MAC in elderly patients.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Elderly persons</subject><subject>Female</subject><subject>Gastric aspirate</subject><subject>Humans</subject><subject>Male</subject><subject>Mycobacterium avium-intracellulare Infection - diagnosis</subject><subject>Nontuberculous mycobacteriosis</subject><subject>Tuberculosis, Pulmonary - diagnosis</subject><issn>0300-9173</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkD1PwzAQhj2AaPn4ASzIE1uKHTtxMqKKAlIlFhCj5VwurSs3KXYy5N9jlKqVWHyy9LzPnV5C7jlbCC7F0wa9Nb23EBZSLjImLsicCcaSkisxI9ch7BjLMpmnV2TGVZGqgrM5-V4621owjoZ-qEfatdQN7YbWNqAJSMEMAWtajbTt2qQfKvQwuG4IdD9CVxno494u2EBtS_stUnQ1ejfeksvGuIB3x3lDvlYvn8u3ZP3x-r58XieQqlQkAtMGgBlgeVEKpfI8S8GwJjOFVCkKXjYlk6ks6yZ-JGeyFmWheJWDgpw34oY8Tt6D734GDL3e2wDonGkxXqnzIoZlKSLIJxB8F4LHRh-83Rs_as70X4P63KCWUscGY-bhKB-qPdbnxLG-CKwmYBd6s8ETYHxvweE_pZyeaD4BsDVeYyt-ATXDi68</recordid><startdate>200707</startdate><enddate>200707</enddate><creator>Sugihara, Eiichiro</creator><creator>Dambara, Takashi</creator><creator>Aiba, Miyoji</creator><creator>Fukuda, Yukiko</creator><creator>Nakajima, Naoya</creator><creator>Inui, Akihiro</creator><creator>Matsumoto, Naomi</creator><creator>Hada, Naoko</creator><creator>Katayama, Akiko</creator><creator>Naito, Toshio</creator><creator>Isonuma, Hiroshi</creator><creator>Hayashida, Yasuo</creator><general>The Japan Geriatrics Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200707</creationdate><title>Clinical study on lung disease caused by non-tuberculous mycobacteriosis in the elderly</title><author>Sugihara, Eiichiro ; Dambara, Takashi ; Aiba, Miyoji ; Fukuda, Yukiko ; Nakajima, Naoya ; Inui, Akihiro ; Matsumoto, Naomi ; Hada, Naoko ; Katayama, Akiko ; Naito, Toshio ; Isonuma, Hiroshi ; Hayashida, Yasuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2723-3e2fcc0ac06893776652ca0f5a8472e319f904249dfe314104d39871b6c7c61f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Elderly persons</topic><topic>Female</topic><topic>Gastric aspirate</topic><topic>Humans</topic><topic>Male</topic><topic>Mycobacterium avium-intracellulare Infection - diagnosis</topic><topic>Nontuberculous mycobacteriosis</topic><topic>Tuberculosis, Pulmonary - diagnosis</topic><toplevel>online_resources</toplevel><creatorcontrib>Sugihara, Eiichiro</creatorcontrib><creatorcontrib>Dambara, Takashi</creatorcontrib><creatorcontrib>Aiba, Miyoji</creatorcontrib><creatorcontrib>Fukuda, Yukiko</creatorcontrib><creatorcontrib>Nakajima, Naoya</creatorcontrib><creatorcontrib>Inui, Akihiro</creatorcontrib><creatorcontrib>Matsumoto, Naomi</creatorcontrib><creatorcontrib>Hada, Naoko</creatorcontrib><creatorcontrib>Katayama, Akiko</creatorcontrib><creatorcontrib>Naito, Toshio</creatorcontrib><creatorcontrib>Isonuma, Hiroshi</creatorcontrib><creatorcontrib>Hayashida, Yasuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nihon Rōnen Igakkai zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugihara, Eiichiro</au><au>Dambara, Takashi</au><au>Aiba, Miyoji</au><au>Fukuda, Yukiko</au><au>Nakajima, Naoya</au><au>Inui, Akihiro</au><au>Matsumoto, Naomi</au><au>Hada, Naoko</au><au>Katayama, Akiko</au><au>Naito, Toshio</au><au>Isonuma, Hiroshi</au><au>Hayashida, Yasuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical study on lung disease caused by non-tuberculous mycobacteriosis in the elderly</atitle><jtitle>Nihon Rōnen Igakkai zasshi</jtitle><addtitle>Nippon Ronen Igakkai Zasshi</addtitle><date>2007-07</date><risdate>2007</risdate><volume>44</volume><issue>4</issue><spage>503</spage><epage>506</epage><pages>503-506</pages><issn>0300-9173</issn><abstract>Aim: This study was done to clarify the characteristics of elderly patients with nontuberculous mycobacteriosis. Methods: We investigated the clinical features of 10 patients at an advanced age who had been given diagnosis of nontuberculous mycobacteriosis. Results: Mycobacterium avium intracellulare complex (MAC) were detected in all cases. The age of the patients ranged from 65 to 92. Four cases had underlying respiratory diseases (old pulmonary tuberculosis in 3 cases, pulmonary emphysema in 1 case, bronchiectasia in 1 case). Six cases suffered from dementia. The symptoms were relatively nonspecific, such as low grade fever, fatigue, appetite loss in almost all cases in this study. On computed tomography (CT) scans of the chest, mainly small nodular infiltrates were seen. MAC was detected in clinical samples such as sputum, gastric juice and bronchial lavage. The examination of gastric juice was performed in 6 out of the 10 cases. Gastric juice samples were smear-positive for acid-fast bacilli in 5 of 6, and culture-positive for MAC in 5 of 6. The detection of MAC in gastric juice samples was higher than that in sputum samples on admission. Conclusion: Gastric juice might be useful to differentiate infection from casual isolation of MAC in elderly patients.</abstract><cop>Japan</cop><pub>The Japan Geriatrics Society</pub><pmid>17827810</pmid><doi>10.3143/geriatrics.44.503</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Elderly persons Female Gastric aspirate Humans Male Mycobacterium avium-intracellulare Infection - diagnosis Nontuberculous mycobacteriosis Tuberculosis, Pulmonary - diagnosis |
| title | Clinical study on lung disease caused by non-tuberculous mycobacteriosis in the elderly |
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