Stabilization of G-Quadruplex DNA by Highly Selective Ligands via Click Chemistry

A series of G-quadruplex stabilizing compounds have been prepared via click chemistry employing the Cu(I)-catalyzed Huisgen reaction. These compounds were shown to bind tightly to G-quadruplex DNA even in the presence of competing high concentrations of duplex DNA. Furthermore, a modified TRAP assay...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American Chemical Society 2006-12, Vol.128 (50), p.15972-15973
Hauptverfasser: Moorhouse, Adam D, Santos, Ana Mafalda, Gunaratnam, Mekala, Moore, Michael, Neidle, Stephen, Moses, John E
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!