Determination of Digoxin in Human Serum Using Stable Isotope Dilution Liquid Chromatography/Electrospray Ionization-Tandem Mass Spectrometry

A method for the determination of digoxin in human serum using a liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) technique is reported. Digoxin and the internal standard, [21,21,22-2H3]digoxin, were extracted from 250 μl of human serum using a solid phase extrac...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2007/09/01, Vol.30(9), pp.1653-1656
Hauptverfasser:	Mitamura, Kuniko, Horikawa, Aki, Yamane, Yuko, Ikeda, Yukari, Fujii, Youichi, Shimada, Kazutake
Format:	Artikel
Sprache:	eng
Schlagworte:	Calibration Chromatography, Liquid correlation digitalized patient digoxin Digoxin - blood Humans Indicators and Reagents liquid chromatography/tandem mass spectrometry Radioimmunoassay Radioisotope Dilution Technique Reproducibility of Results serum Spectrometry, Mass, Electrospray Ionization
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