Haplotypic variation in MRE11, RAD50 and NBS1 and risk of non-Hodgkin's lymphoma

The MRE11-RAD50-NBS1 tri-complex is involved in the cellular response to DNA double strand breaks, detecting DNA damage, activating cell cycle checkpoints and apoptosis. Defects in members of the tri-complex are linked to increased chromosomal instability and in lymphoma predisposition. Using genoty...

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Veröffentlicht in:	Leukemia & lymphoma 2006-12, Vol.47 (12), p.2567-2583
Hauptverfasser:	Rollinson, Sara, Kesby, Heather, Morgan, Gareth J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases Adolescent Adult Cell Cycle Proteins - genetics DNA Repair DNA Repair Enzymes - genetics DNA-Binding Proteins - genetics Female Genotype Haplotypes Humans Linkage Disequilibrium Lymphoma, Non-Hodgkin - diagnosis Lymphoma, Non-Hodgkin - genetics Male Middle Aged MRE11 Homologue Protein non-Hodgkin's lymphoma Nuclear Proteins - genetics Risk
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