Identification of a novel virus in pigs—Bungowannah virus: A possible new species of pestivirus
In 2003 an outbreak of sudden deaths occurred in 3–4-week-old piglets on a farm in New South Wales, Australia. There was a marked increase in the birth of stillborn foetuses. Pathological changes consisted of a multifocal non-suppurative myocarditis. A viral infection was suspected but a wide range...
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| Veröffentlicht in: | Virus research 2007-10, Vol.129 (1), p.26-34 |
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| creator | Kirkland, P.D. Frost, M.J. Finlaison, D.S. King, K.R. Ridpath, J.F. Gu, X. |
| description | In 2003 an outbreak of sudden deaths occurred in 3–4-week-old piglets on a farm in New South Wales, Australia. There was a marked increase in the birth of stillborn foetuses. Pathological changes consisted of a multifocal non-suppurative myocarditis. A viral infection was suspected but a wide range of known agents were excluded. A modified sequence independent single primer amplification (SISPA) method was used to identify a novel virus associated with this outbreak. Conserved 5′UTR motifs, the presence of a putative N
pro coding region and limited antigenic cross-reactivity with other members of the
Pestivirus genus, support the placement of this virus in the
Pestivirus genus. Phylogenetic analysis of the 5′UTR, N
pro and E2 coding regions showed this virus to be the most divergent pestivirus identified to date. |
| doi_str_mv | 10.1016/j.virusres.2007.05.002 |
| format | Article |
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pro coding region and limited antigenic cross-reactivity with other members of the
Pestivirus genus, support the placement of this virus in the
Pestivirus genus. Phylogenetic analysis of the 5′UTR, N
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pro coding region and limited antigenic cross-reactivity with other members of the
Pestivirus genus, support the placement of this virus in the
Pestivirus genus. Phylogenetic analysis of the 5′UTR, N
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Frost, M.J. ; Finlaison, D.S. ; King, K.R. ; Ridpath, J.F. ; Gu, X.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-e8fa1e62add84c284b5aba86c68bfb5ec3aba757137c3e95b8d1790ce0113e503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>5' Untranslated Regions - genetics</topic><topic>Animals</topic><topic>Antigens, Viral - immunology</topic><topic>Australia</topic><topic>Bungowannah virus</topic><topic>Cross Reactions</topic><topic>Disease Outbreaks</topic><topic>Endopeptidases - genetics</topic><topic>Heparin Lyase</topic><topic>Myocarditis - pathology</topic><topic>Open Reading Frames - genetics</topic><topic>Pestivirus</topic><topic>Pestivirus - genetics</topic><topic>Pestivirus - immunology</topic><topic>Pestivirus - isolation & purification</topic><topic>Pestivirus Infections - epidemiology</topic><topic>Pestivirus Infections - pathology</topic><topic>Pestivirus Infections - veterinary</topic><topic>Pestivirus Infections - virology</topic><topic>Porcine myocarditis syndrome</topic><topic>Ribonucleases - genetics</topic><topic>Sus scrofa</topic><topic>Swine Diseases - epidemiology</topic><topic>Swine Diseases - pathology</topic><topic>Swine Diseases - virology</topic><topic>Viral Envelope Proteins - genetics</topic><topic>Viral Proteins - genetics</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kirkland, P.D.</creatorcontrib><creatorcontrib>Frost, M.J.</creatorcontrib><creatorcontrib>Finlaison, D.S.</creatorcontrib><creatorcontrib>King, K.R.</creatorcontrib><creatorcontrib>Ridpath, J.F.</creatorcontrib><creatorcontrib>Gu, X.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virus research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kirkland, P.D.</au><au>Frost, M.J.</au><au>Finlaison, D.S.</au><au>King, K.R.</au><au>Ridpath, J.F.</au><au>Gu, X.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of a novel virus in pigs—Bungowannah virus: A possible new species of pestivirus</atitle><jtitle>Virus research</jtitle><addtitle>Virus Res</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>129</volume><issue>1</issue><spage>26</spage><epage>34</epage><pages>26-34</pages><issn>0168-1702</issn><eissn>1872-7492</eissn><abstract>In 2003 an outbreak of sudden deaths occurred in 3–4-week-old piglets on a farm in New South Wales, Australia. There was a marked increase in the birth of stillborn foetuses. Pathological changes consisted of a multifocal non-suppurative myocarditis. A viral infection was suspected but a wide range of known agents were excluded. A modified sequence independent single primer amplification (SISPA) method was used to identify a novel virus associated with this outbreak. Conserved 5′UTR motifs, the presence of a putative N
pro coding region and limited antigenic cross-reactivity with other members of the
Pestivirus genus, support the placement of this virus in the
Pestivirus genus. Phylogenetic analysis of the 5′UTR, N
pro and E2 coding regions showed this virus to be the most divergent pestivirus identified to date.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17561301</pmid><doi>10.1016/j.virusres.2007.05.002</doi><tpages>9</tpages></addata></record> |
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| subjects | 5' Untranslated Regions - genetics Animals Antigens, Viral - immunology Australia Bungowannah virus Cross Reactions Disease Outbreaks Endopeptidases - genetics Heparin Lyase Myocarditis - pathology Open Reading Frames - genetics Pestivirus Pestivirus - genetics Pestivirus - immunology Pestivirus - isolation & purification Pestivirus Infections - epidemiology Pestivirus Infections - pathology Pestivirus Infections - veterinary Pestivirus Infections - virology Porcine myocarditis syndrome Ribonucleases - genetics Sus scrofa Swine Diseases - epidemiology Swine Diseases - pathology Swine Diseases - virology Viral Envelope Proteins - genetics Viral Proteins - genetics Weaning |
| title | Identification of a novel virus in pigs—Bungowannah virus: A possible new species of pestivirus |
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