Mechanisms of Cellular Avidity Regulation in CD2–CD58-Mediated T Cell Adhesion

The CD2 receptor on T lymphocytes is essential for T cell adhesion and stimulation by antigen presenting cells (APCs). Blockade of CD2 function is immunosuppressive in both model systems and humans, indicating the importance of CD2 for the cellular immune response. Although the affinity of the molec...

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Veröffentlicht in:	ACS chemical biology 2006-11, Vol.1 (10), p.649-658
Hauptverfasser:	Zhu, De-Min, Dustin, Michael L, Cairo, Christopher W, Thatte, Hemant S, Golan, David E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody Affinity Antigen-Presenting Cells - metabolism CD2 Antigens - biosynthesis CD58 Antigens - biosynthesis Cell Adhesion Fluorescein-5-isothiocyanate - pharmacology Fluorescent Dyes - pharmacology Humans Immunosuppressive Agents - pharmacology Jurkat Cells Kinetics Lipid Bilayers - chemistry Protein Binding Surface Plasmon Resonance T-Lymphocytes - cytology T-Lymphocytes - metabolism
Online-Zugang:	Volltext
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