Increased Incidence of Squamous Cell Carcinoma of Eye After Kidney Transplantation

Squamous cell carcinoma (SCC) of the eye occurs at substantially increased rates in individuals with human immunodeficiency virus (HIV) infection, but it has not been reported in individuals with iatrogenic or congenital immune deficiency. In a national, population-based cohort of 10180 renal transp...

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Veröffentlicht in:JNCI : Journal of the National Cancer Institute 2007-09, Vol.99 (17), p.1340-1342
Hauptverfasser: Vajdic, Claire M., van Leeuwen, Marina T., McDonald, Stephen P., McCredie, Margaret R. E., Law, Matthew, Chapman, Jeremy R., Webster, Angela C., Kaldor, John M., Grulich, Andrew E.
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container_end_page 1342
container_issue 17
container_start_page 1340
container_title JNCI : Journal of the National Cancer Institute
container_volume 99
creator Vajdic, Claire M.
van Leeuwen, Marina T.
McDonald, Stephen P.
McCredie, Margaret R. E.
Law, Matthew
Chapman, Jeremy R.
Webster, Angela C.
Kaldor, John M.
Grulich, Andrew E.
description Squamous cell carcinoma (SCC) of the eye occurs at substantially increased rates in individuals with human immunodeficiency virus (HIV) infection, but it has not been reported in individuals with iatrogenic or congenital immune deficiency. In a national, population-based cohort of 10180 renal transplantation patients from Australia with 86898 person-years of follow-up, we ascertained primary incident cancers diagnosed in 1982–2003 by record linkage between the Australia and New Zealand Dialysis and Transplant Registry and the Australian National Cancer Statistics Clearing House. Standardized incidence ratios (SIRs) of cancer were calculated using age-, sex-, calendar year–, and state/territory–specific population cancer incidence rates. Statistical tests were two-sided. Five patients were diagnosed with ocular SCC after kidney transplantation (0.26 were expected), and the incidence was increased 20-fold (SIR = 19.5, 95% confidence interval [CI] = 6.3 to 45.5). Compared with the entire cohort, the five patients with ocular SCC after transplantation were more likely to have resided in the subtropical state of Queensland (60% versus 17%, P = .04), to have had end-stage kidney disease as a result of glomerulonephritis (100% versus 46%, P = .02), and to have a history of cutaneous SCC (100% versus 29%, P = .002). The increased incidence of ocular SCC after kidney transplantation and after HIV infection strongly suggests that this neoplasm is an immune deficiency–associated cancer. Our data also support an interaction between immune suppression and sun exposure in the development of ocular SCC after kidney transplantation.
doi_str_mv 10.1093/jnci/djm085
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subjects Australia - epidemiology
Biological and medical sciences
Cancer
Carcinoma, Squamous Cell - epidemiology
Eye Neoplasms - epidemiology
Eyes & eyesight
Human immunodeficiency virus
Humans
Incidence
Kidney Transplantation - adverse effects
Kidneys
Male
Medical sciences
Middle Aged
Oncology
Patients
Postoperative Complications - epidemiology
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Time Factors
Transplants & implants
Tropical medicine
Tumors
title Increased Incidence of Squamous Cell Carcinoma of Eye After Kidney Transplantation
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