Hormonal therapy of the brain-dead organ donor : Experimental and clinical studies
Experiments in Cape Town in the 1980s demonstrated that acute brain death is followed by massive catecholamine release resulting in systemic hypertension, acute left ventricular failure, and multiple cardiac arrhythmias along with substantial decreases in cortisol, insulin, thyroid, and antidiuretic...
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| Veröffentlicht in: | Transplantation 2006-12, Vol.82 (11), p.1396-1401 |
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| container_title | Transplantation |
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| creator | NOVITZKY, Dmitri COOPER, David K. C ROSENDALE, John D MYRON KAUFFMAN, H |
| description | Experiments in Cape Town in the 1980s demonstrated that acute brain death is followed by massive catecholamine release resulting in systemic hypertension, acute left ventricular failure, and multiple cardiac arrhythmias along with substantial decreases in cortisol, insulin, thyroid, and antidiuretic hormone levels, a change from aerobic to anaerobic metabolism, and increases in inflammatory cytokines. Hormonal replacement results in rapid recovery of cardiac function in both experimental animals and humans and enables significantly more organs to be transplanted. Organ Procurement and Transplantation Network/United Network for Organ Sharing multivariate studies on hormonal treatment of brain-dead donors revealed significant increases in organs transplanted and in one-year survival of kidneys and hearts. |
| doi_str_mv | 10.1097/01.tp.0000237195.12342.f1 |
| format | Article |
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Psychology ; Fundamental immunology ; Graft Rejection - prevention & control ; Heart Transplantation ; Hormone Replacement Therapy ; Hormones - administration & dosage ; Humans ; Kidney Transplantation ; Medical sciences ; South Africa ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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C</creatorcontrib><creatorcontrib>ROSENDALE, John D</creatorcontrib><creatorcontrib>MYRON KAUFFMAN, H</creatorcontrib><title>Hormonal therapy of the brain-dead organ donor : Experimental and clinical studies</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Experiments in Cape Town in the 1980s demonstrated that acute brain death is followed by massive catecholamine release resulting in systemic hypertension, acute left ventricular failure, and multiple cardiac arrhythmias along with substantial decreases in cortisol, insulin, thyroid, and antidiuretic hormone levels, a change from aerobic to anaerobic metabolism, and increases in inflammatory cytokines. Hormonal replacement results in rapid recovery of cardiac function in both experimental animals and humans and enables significantly more organs to be transplanted. Organ Procurement and Transplantation Network/United Network for Organ Sharing multivariate studies on hormonal treatment of brain-dead donors revealed significant increases in organs transplanted and in one-year survival of kidneys and hearts.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Death - metabolism</subject><subject>Clinical death. Palliative care. Organ gift and preservation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Rejection - prevention & control</subject><subject>Heart Transplantation</subject><subject>Hormone Replacement Therapy</subject><subject>Hormones - administration & dosage</subject><subject>Humans</subject><subject>Kidney Transplantation</subject><subject>Medical sciences</subject><subject>South Africa</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue Donors</subject><subject>Tissue, organ and graft immunology</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BakHvbXOJGnTepNl_QBBED2HNEm10k1q0gX33xvdhT06l0zgeTOTh5ALhAKhEdeAxTQWkIoygU1ZIGWcFh3ukRmWjOcV1LBPZgAcc2RMHJHjGD8TXzIhDskRCqy4AD4jLw8-LL1TQzZ92KDGdea73zZrg-pdbqwymQ_vymXGOx-ym2zxPdrQL62bUkg5k-mhd71OlzitTG_jKTno1BDt2fY8IW93i9f5Q_70fP84v33KNadiyrHhIChluu06VSnKmLaUWsEN8pI22tYJ0w21rBRNS7k2KGorDAhoK0j8CbnavDsG_7WycZLLPmo7DMpZv4qyqinnANW_YNqkqcuaJbDZgDr4GIPt5Jh-qsJaIshf8xJQTqPcmZd_5mWHKXu-HbJql9bsklvVCbjcAiomW11QTvdxx9VM1LwS7Ae68YvG</recordid><startdate>20061215</startdate><enddate>20061215</enddate><creator>NOVITZKY, Dmitri</creator><creator>COOPER, David K. 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| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 2006-12, Vol.82 (11), p.1396-1401 |
| issn | 0041-1337 1534-6080 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Brain Death - metabolism Clinical death. Palliative care. Organ gift and preservation Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection - prevention & control Heart Transplantation Hormone Replacement Therapy Hormones - administration & dosage Humans Kidney Transplantation Medical sciences South Africa Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Donors Tissue, organ and graft immunology |
| title | Hormonal therapy of the brain-dead organ donor : Experimental and clinical studies |
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