Post-transplant soluble MICA and MICA antibodies predict subsequent heart graft outcome
The objective of this retrospective study was to evaluate the role of MICA in heart graft acceptance. Pre- and post-transplant sera from 31 patients were evaluated for MICA antibodies by cytotoxicity on recombinant cell lines and soluble MICA (sMICA) concentrations by ELISA. The results demonstrated...
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| Veröffentlicht in: | Transplant Immunology 2006-12, Vol.17 (1), p.43-46 |
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| creator | Suárez-Álvarez, Beatriz López-Vázquez, Antonio Díaz-Peña, Roberto Díaz-Molina, Beatriz Blanco-García, Rosa M. Álvarez-López, M. Rocío López-Larrea, Carlos |
| description | The objective of this retrospective study was to evaluate the role of MICA in heart graft acceptance. Pre- and post-transplant sera from 31 patients were evaluated for MICA antibodies by cytotoxicity on recombinant cell lines and soluble MICA (sMICA) concentrations by ELISA. The results demonstrated that the patients with post-transplant anti-MICA antibodies were at a high risk for the development of severe acute rejection (AR) (
p
<
0.03; OR
=
8.5). However, the presence of post-transplant sMICA was found to be associated with functioning grafts without AR episodes (
p
<
0.03, OR
=
7.9). In this preliminary survey, the negative association of sMICA with AR was found to be in the absence of MICA antibodies. Further research is needed to clarify the role of sMICA in allograft acceptance. Post-transplant evaluation of humoral immune response to MICA and the measure of sMICA in patient's sera may provide a good predictor of AR. |
| doi_str_mv | 10.1016/j.trim.2006.09.014 |
| format | Article |
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p
<
0.03; OR
=
8.5). However, the presence of post-transplant sMICA was found to be associated with functioning grafts without AR episodes (
p
<
0.03, OR
=
7.9). In this preliminary survey, the negative association of sMICA with AR was found to be in the absence of MICA antibodies. Further research is needed to clarify the role of sMICA in allograft acceptance. Post-transplant evaluation of humoral immune response to MICA and the measure of sMICA in patient's sera may provide a good predictor of AR.</description><identifier>ISSN: 0966-3274</identifier><identifier>EISSN: 1878-5492</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1016/j.trim.2006.09.014</identifier><identifier>PMID: 17157214</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acute Disease ; Adult ; Base Sequence ; Cell Line ; Cytotoxicity, Immunologic ; DNA, Complementary - genetics ; Enzyme-Linked Immunosorbent Assay ; Female ; Graft Rejection - etiology ; Graft Rejection - immunology ; Heart transplantation ; Heart Transplantation - adverse effects ; Heart Transplantation - immunology ; Histocompatibility Antigens Class I - blood ; Histocompatibility Antigens Class I - genetics ; Humans ; Isoantibodies - blood ; Male ; MICA antibodies ; Middle Aged ; Recombinant Proteins - genetics ; Recombinant Proteins - immunology ; Rejection ; Retrospective Studies ; Solubility ; Soluble MICA ; Treatment Outcome</subject><ispartof>Transplant Immunology, 2006-12, Vol.17 (1), p.43-46</ispartof><rights>2006 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-b47609b006f31b971ceb475b7568e6698bf24f4acd7f1fca1ee81d76752ae2bc3</citedby><cites>FETCH-LOGICAL-c385t-b47609b006f31b971ceb475b7568e6698bf24f4acd7f1fca1ee81d76752ae2bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.trim.2006.09.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17157214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suárez-Álvarez, Beatriz</creatorcontrib><creatorcontrib>López-Vázquez, Antonio</creatorcontrib><creatorcontrib>Díaz-Peña, Roberto</creatorcontrib><creatorcontrib>Díaz-Molina, Beatriz</creatorcontrib><creatorcontrib>Blanco-García, Rosa M.</creatorcontrib><creatorcontrib>Álvarez-López, M. Rocío</creatorcontrib><creatorcontrib>López-Larrea, Carlos</creatorcontrib><title>Post-transplant soluble MICA and MICA antibodies predict subsequent heart graft outcome</title><title>Transplant Immunology</title><addtitle>Transpl Immunol</addtitle><description>The objective of this retrospective study was to evaluate the role of MICA in heart graft acceptance. Pre- and post-transplant sera from 31 patients were evaluated for MICA antibodies by cytotoxicity on recombinant cell lines and soluble MICA (sMICA) concentrations by ELISA. The results demonstrated that the patients with post-transplant anti-MICA antibodies were at a high risk for the development of severe acute rejection (AR) (
p
<
0.03; OR
=
8.5). However, the presence of post-transplant sMICA was found to be associated with functioning grafts without AR episodes (
p
<
0.03, OR
=
7.9). In this preliminary survey, the negative association of sMICA with AR was found to be in the absence of MICA antibodies. Further research is needed to clarify the role of sMICA in allograft acceptance. Post-transplant evaluation of humoral immune response to MICA and the measure of sMICA in patient's sera may provide a good predictor of AR.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Base Sequence</subject><subject>Cell Line</subject><subject>Cytotoxicity, Immunologic</subject><subject>DNA, Complementary - genetics</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Graft Rejection - etiology</subject><subject>Graft Rejection - immunology</subject><subject>Heart transplantation</subject><subject>Heart Transplantation - adverse effects</subject><subject>Heart Transplantation - immunology</subject><subject>Histocompatibility Antigens Class I - blood</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Humans</subject><subject>Isoantibodies - blood</subject><subject>Male</subject><subject>MICA antibodies</subject><subject>Middle Aged</subject><subject>Recombinant Proteins - genetics</subject><subject>Recombinant Proteins - immunology</subject><subject>Rejection</subject><subject>Retrospective Studies</subject><subject>Solubility</subject><subject>Soluble MICA</subject><subject>Treatment Outcome</subject><issn>0966-3274</issn><issn>1878-5492</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1KxDAURoMozjj6Ai6kK3etSZomDbiRwT8Y0YXiMiTprXboNGOSCr69GWbEna5yCef7uPcgdEpwQTDhF8si-m5VUIx5gWWBCdtDU1KLOq-YpPtoiiXneUkFm6CjEJYYY1pJcYgmRJBKUMKm6PXJhZhHr4ew7vUQs-D60fSQPdzPrzI9ND9D7IxrOgjZ2kPT2QSOJsDHCCnzDtrH7M3rNmZujNat4BgdtLoPcLJ7Z-jl5vp5fpcvHm9T4SK3ZV3F3DDBsTTpgrYkRgpiIX1VRlS8Bs5lbVrKWqZtI1rSWk0AatIILiqqgRpbztD5tnftXVomRLXqgoU-3QJuDIrXlJWCy39BItMqpGQJpFvQeheCh1atk2XtvxTBauNdLdXGu9p4V1iq5D2Fznbto1lB8xvZiU7A5RaAJOOzA6-C7WCwyaUHG1Xjur_6vwH-sJSd</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Suárez-Álvarez, Beatriz</creator><creator>López-Vázquez, Antonio</creator><creator>Díaz-Peña, Roberto</creator><creator>Díaz-Molina, Beatriz</creator><creator>Blanco-García, Rosa M.</creator><creator>Álvarez-López, M. Rocío</creator><creator>López-Larrea, Carlos</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Post-transplant soluble MICA and MICA antibodies predict subsequent heart graft outcome</title><author>Suárez-Álvarez, Beatriz ; López-Vázquez, Antonio ; Díaz-Peña, Roberto ; Díaz-Molina, Beatriz ; Blanco-García, Rosa M. ; Álvarez-López, M. Rocío ; López-Larrea, Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-b47609b006f31b971ceb475b7568e6698bf24f4acd7f1fca1ee81d76752ae2bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Base Sequence</topic><topic>Cell Line</topic><topic>Cytotoxicity, Immunologic</topic><topic>DNA, Complementary - genetics</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Graft Rejection - etiology</topic><topic>Graft Rejection - immunology</topic><topic>Heart transplantation</topic><topic>Heart Transplantation - adverse effects</topic><topic>Heart Transplantation - immunology</topic><topic>Histocompatibility Antigens Class I - blood</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>Humans</topic><topic>Isoantibodies - blood</topic><topic>Male</topic><topic>MICA antibodies</topic><topic>Middle Aged</topic><topic>Recombinant Proteins - genetics</topic><topic>Recombinant Proteins - immunology</topic><topic>Rejection</topic><topic>Retrospective Studies</topic><topic>Solubility</topic><topic>Soluble MICA</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suárez-Álvarez, Beatriz</creatorcontrib><creatorcontrib>López-Vázquez, Antonio</creatorcontrib><creatorcontrib>Díaz-Peña, Roberto</creatorcontrib><creatorcontrib>Díaz-Molina, Beatriz</creatorcontrib><creatorcontrib>Blanco-García, Rosa M.</creatorcontrib><creatorcontrib>Álvarez-López, M. Rocío</creatorcontrib><creatorcontrib>López-Larrea, Carlos</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suárez-Álvarez, Beatriz</au><au>López-Vázquez, Antonio</au><au>Díaz-Peña, Roberto</au><au>Díaz-Molina, Beatriz</au><au>Blanco-García, Rosa M.</au><au>Álvarez-López, M. Rocío</au><au>López-Larrea, Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-transplant soluble MICA and MICA antibodies predict subsequent heart graft outcome</atitle><jtitle>Transplant Immunology</jtitle><addtitle>Transpl Immunol</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>17</volume><issue>1</issue><spage>43</spage><epage>46</epage><pages>43-46</pages><issn>0966-3274</issn><eissn>1878-5492</eissn><eissn>1365-2567</eissn><abstract>The objective of this retrospective study was to evaluate the role of MICA in heart graft acceptance. Pre- and post-transplant sera from 31 patients were evaluated for MICA antibodies by cytotoxicity on recombinant cell lines and soluble MICA (sMICA) concentrations by ELISA. The results demonstrated that the patients with post-transplant anti-MICA antibodies were at a high risk for the development of severe acute rejection (AR) (
p
<
0.03; OR
=
8.5). However, the presence of post-transplant sMICA was found to be associated with functioning grafts without AR episodes (
p
<
0.03, OR
=
7.9). In this preliminary survey, the negative association of sMICA with AR was found to be in the absence of MICA antibodies. Further research is needed to clarify the role of sMICA in allograft acceptance. Post-transplant evaluation of humoral immune response to MICA and the measure of sMICA in patient's sera may provide a good predictor of AR.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17157214</pmid><doi>10.1016/j.trim.2006.09.014</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Wiley Free Content; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acute Disease Adult Base Sequence Cell Line Cytotoxicity, Immunologic DNA, Complementary - genetics Enzyme-Linked Immunosorbent Assay Female Graft Rejection - etiology Graft Rejection - immunology Heart transplantation Heart Transplantation - adverse effects Heart Transplantation - immunology Histocompatibility Antigens Class I - blood Histocompatibility Antigens Class I - genetics Humans Isoantibodies - blood Male MICA antibodies Middle Aged Recombinant Proteins - genetics Recombinant Proteins - immunology Rejection Retrospective Studies Solubility Soluble MICA Treatment Outcome |
| title | Post-transplant soluble MICA and MICA antibodies predict subsequent heart graft outcome |
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