Matrix metalloproteinase-9 −1562 C/T gene polymorphism in Serbian patients with multiple sclerosis
Abstract Matrix metalloproteinase-9 (MMP-9) is suggested to play a role in MS by mediating T cell migration across subendothelial basement membrane and by contribution to myelin breakdown. We studied the association of MMP-9 −1562 C/T gene polymorphisms with MS susceptibility and severity in 187 pat...
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| Veröffentlicht in: | Journal of neuroimmunology 2007-09, Vol.189 (1), p.147-150 |
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| creator | ZIVKOVIC, M DJURIC, T DINCIC, E RAICEVIC, R ALAVANTIC, D STANKOVIC, A |
| description | Abstract Matrix metalloproteinase-9 (MMP-9) is suggested to play a role in MS by mediating T cell migration across subendothelial basement membrane and by contribution to myelin breakdown. We studied the association of MMP-9 −1562 C/T gene polymorphisms with MS susceptibility and severity in 187 patients from Serbia. The significant decrease in T allele carriership ( p = 0.01), was found in female MS patients. In addition, a trend toward lower MSSS in T allele carriers was noticed (CC, mean 5.7 ± 2.5 vs. CT + TT, mean 4.9 ± 2.5). Further studies in different populations are needed to resolve the potential influence of MMP-9 gene polymorphism on MS. |
| doi_str_mv | 10.1016/j.jneuroim.2007.06.022 |
| format | Article |
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We studied the association of MMP-9 −1562 C/T gene polymorphisms with MS susceptibility and severity in 187 patients from Serbia. The significant decrease in T allele carriership ( p = 0.01), was found in female MS patients. In addition, a trend toward lower MSSS in T allele carriers was noticed (CC, mean 5.7 ± 2.5 vs. CT + TT, mean 4.9 ± 2.5). Further studies in different populations are needed to resolve the potential influence of MMP-9 gene polymorphism on MS.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2007.06.022</identifier><identifier>PMID: 17655938</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Alleles ; Allergy and Immunology ; Female ; Gene ; Gene Frequency ; Genetic Predisposition to Disease ; Humans ; Male ; Matrix Metalloproteinase 9 - genetics ; Middle Aged ; MMP-9 ; Multiple sclerosis ; Multiple Sclerosis - genetics ; Neurology ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Severity of Illness Index ; Sex Factors ; Statistics, Nonparametric ; Yugoslavia - epidemiology</subject><ispartof>Journal of neuroimmunology, 2007-09, Vol.189 (1), p.147-150</ispartof><rights>Elsevier B.V.</rights><rights>2007 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-577a1e729be09492b3928faecdd7cf3a475b2f23d26bc4698ca39a8916a0db193</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2007.06.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17655938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZIVKOVIC, M</creatorcontrib><creatorcontrib>DJURIC, T</creatorcontrib><creatorcontrib>DINCIC, E</creatorcontrib><creatorcontrib>RAICEVIC, R</creatorcontrib><creatorcontrib>ALAVANTIC, D</creatorcontrib><creatorcontrib>STANKOVIC, A</creatorcontrib><title>Matrix metalloproteinase-9 −1562 C/T gene polymorphism in Serbian patients with multiple sclerosis</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract Matrix metalloproteinase-9 (MMP-9) is suggested to play a role in MS by mediating T cell migration across subendothelial basement membrane and by contribution to myelin breakdown. 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Further studies in different populations are needed to resolve the potential influence of MMP-9 gene polymorphism on MS.</description><subject>Adult</subject><subject>Alleles</subject><subject>Allergy and Immunology</subject><subject>Female</subject><subject>Gene</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Male</subject><subject>Matrix Metalloproteinase 9 - genetics</subject><subject>Middle Aged</subject><subject>MMP-9</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - genetics</subject><subject>Neurology</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Severity of Illness Index</subject><subject>Sex Factors</subject><subject>Statistics, Nonparametric</subject><subject>Yugoslavia - epidemiology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkstu1DAUhi1ERYfCK1ResUvqS2LHGwQaQUEq6qJlbTnOCXVwLtgOMG_Auo_Ik-DRDKrUTVdn8_3n8v8HoXNKSkqouBjKYYI1zG4sGSGyJKIkjD1DG9pIVjQVo8_RJoN1UUvWnKKXMQ6E0JpX6gU6pVLUteLNBnVfTAruNx4hGe_nJcwJ3GQiFAr__XNPa8Hw9uIWf4MJ8DL73TiH5c7FEbsJ30BonZnwYpKDKUX8y6U7PK4-ucUDjtZDmKOLr9BJb3yE18d6hr5-_HC7_VRcXV9-3r6_KmxVs5Q3lYaCZKoFoirFWq5Y0xuwXSdtz00l65b1jHdMtLYSqrGGK9MoKgzpWqr4GXpz6JvP-LFCTHp00YL3ZoJ5jVo0rOKCN0-CVNUV54pnUBxAmw-JAXq9BDeasNOU6H0QetD_g9D7IDQROgeRhefHCWs7QvcgOzqfgXcHALIhPx0EHW020ULnAtiku9k9PePtoxbWu8lZ47_DDuIwr2HKdmuqI9NE3-zfYf8NRJIsZ4L_A6ncs8g</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>ZIVKOVIC, M</creator><creator>DJURIC, T</creator><creator>DINCIC, E</creator><creator>RAICEVIC, R</creator><creator>ALAVANTIC, D</creator><creator>STANKOVIC, A</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Matrix metalloproteinase-9 −1562 C/T gene polymorphism in Serbian patients with multiple sclerosis</title><author>ZIVKOVIC, M ; 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Alleles Allergy and Immunology Female Gene Gene Frequency Genetic Predisposition to Disease Humans Male Matrix Metalloproteinase 9 - genetics Middle Aged MMP-9 Multiple sclerosis Multiple Sclerosis - genetics Neurology Polymorphism Polymorphism, Single Nucleotide - genetics Severity of Illness Index Sex Factors Statistics, Nonparametric Yugoslavia - epidemiology |
| title | Matrix metalloproteinase-9 −1562 C/T gene polymorphism in Serbian patients with multiple sclerosis |
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