Association of the HLA-DRB115 allele group and the DRB11501 and DRB11503 alleles with multiple sclerosis in White and Mulatto samples from Brazil
Multiple sclerosis (MS) is a multifactorial inflammatory disease that primarily affects the central nervous system. Genes and environmental factors probably interact in MS susceptibility and outcome; however, their roles have not been elucidated yet. The evaluation of the HLA-DRB1 gene in the Brazil...
Gespeichert in:
| Veröffentlicht in: | Journal of neuroimmunology 2007-09, Vol.189 (1-2), p.118-124 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 124 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 118 |
| container_title | Journal of neuroimmunology |
| container_volume | 189 |
| creator | Brum, Doralina Guimarães Barreira, Amilton Antunes Louzada-Junior, Paulo Mendes-Junior, Celso Teixeira Donadi, Eduardo Antônio |
| description | Multiple sclerosis (MS) is a multifactorial inflammatory disease that primarily affects the central nervous system. Genes and environmental factors probably interact in MS susceptibility and outcome; however, their roles have not been elucidated yet. The evaluation of the HLA-DRB1 gene in the Brazilian population is of particular interest in evidencing the behavior of HLA-DRB1 alleles in a highly admixed population inserted in an environment of low MS prevalence. The present results suggest that a given HLA-DRB1 allele may exhibit different behaviors, i.e. confer resistance or susceptibility, in response to the environmental and/or genetic (ethnic) backgrounds that characterize a sampled population. |
| doi_str_mv | 10.1016/j.jneuroim.2007.06.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68243601</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68243601</sourcerecordid><originalsourceid>FETCH-LOGICAL-p209t-30b7cbef8d51b43bc7dd4c1bc5e2901cdd955e0939d73c5567c57fa86578c4693</originalsourceid><addsrcrecordid>eNo1kMtOwzAQRb0A0VL4hcordgl2HNvxsi2PIhUhIRDLyLEd6sqJQ-wIwV_wx5Q2rEYz59xZXADmGKUYYXa9S3etGXpvmzRDiKeIpQiJEzDdQ5pQnhUTcB7CDiFMSS7OwARzVmCG8yn4WYTglZXR-hb6GsatgevNIrl5XmJMoXTOOAPfez90ULb6wI8M4cNhXMioBvhp4xY2g4u22yeDcqb3wQZoW_i2tdEcUo-DkzF6GGTT_YXq3jdw2ctv6y7AaS1dMJfjnIHXu9uX1TrZPN0_rBabpMuQiAlBFVeVqQtNcZWTSnGtc4UrRU0mEFZaC0oNEkRoThSljCvKa1kwyguVM0Fm4Or4t-v9x2BCLBsblHFOtsYPoWRFlhOG8F6cj-JQNUaXXW8b2X-V_yWSX007c3Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68243601</pqid></control><display><type>article</type><title>Association of the HLA-DRB115 allele group and the DRB11501 and DRB11503 alleles with multiple sclerosis in White and Mulatto samples from Brazil</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Brum, Doralina Guimarães ; Barreira, Amilton Antunes ; Louzada-Junior, Paulo ; Mendes-Junior, Celso Teixeira ; Donadi, Eduardo Antônio</creator><creatorcontrib>Brum, Doralina Guimarães ; Barreira, Amilton Antunes ; Louzada-Junior, Paulo ; Mendes-Junior, Celso Teixeira ; Donadi, Eduardo Antônio</creatorcontrib><description>Multiple sclerosis (MS) is a multifactorial inflammatory disease that primarily affects the central nervous system. Genes and environmental factors probably interact in MS susceptibility and outcome; however, their roles have not been elucidated yet. The evaluation of the HLA-DRB1 gene in the Brazilian population is of particular interest in evidencing the behavior of HLA-DRB1 alleles in a highly admixed population inserted in an environment of low MS prevalence. The present results suggest that a given HLA-DRB1 allele may exhibit different behaviors, i.e. confer resistance or susceptibility, in response to the environmental and/or genetic (ethnic) backgrounds that characterize a sampled population.</description><identifier>ISSN: 0165-5728</identifier><identifier>DOI: 10.1016/j.jneuroim.2007.06.009</identifier><identifier>PMID: 17681614</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Adolescent ; Adult ; Alleles ; Brazil - ethnology ; Child ; Ethnic Groups ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Histocompatibility Testing ; HLA-DR Antigens - genetics ; HLA-DRB1 Chains ; Humans ; Male ; Middle Aged ; Multiple Sclerosis - genetics ; Polymorphism, Genetic ; Population Groups</subject><ispartof>Journal of neuroimmunology, 2007-09, Vol.189 (1-2), p.118-124</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17681614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brum, Doralina Guimarães</creatorcontrib><creatorcontrib>Barreira, Amilton Antunes</creatorcontrib><creatorcontrib>Louzada-Junior, Paulo</creatorcontrib><creatorcontrib>Mendes-Junior, Celso Teixeira</creatorcontrib><creatorcontrib>Donadi, Eduardo Antônio</creatorcontrib><title>Association of the HLA-DRB115 allele group and the DRB11501 and DRB11503 alleles with multiple sclerosis in White and Mulatto samples from Brazil</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Multiple sclerosis (MS) is a multifactorial inflammatory disease that primarily affects the central nervous system. Genes and environmental factors probably interact in MS susceptibility and outcome; however, their roles have not been elucidated yet. The evaluation of the HLA-DRB1 gene in the Brazilian population is of particular interest in evidencing the behavior of HLA-DRB1 alleles in a highly admixed population inserted in an environment of low MS prevalence. The present results suggest that a given HLA-DRB1 allele may exhibit different behaviors, i.e. confer resistance or susceptibility, in response to the environmental and/or genetic (ethnic) backgrounds that characterize a sampled population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alleles</subject><subject>Brazil - ethnology</subject><subject>Child</subject><subject>Ethnic Groups</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Histocompatibility Testing</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DRB1 Chains</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Population Groups</subject><issn>0165-5728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOwzAQRb0A0VL4hcordgl2HNvxsi2PIhUhIRDLyLEd6sqJQ-wIwV_wx5Q2rEYz59xZXADmGKUYYXa9S3etGXpvmzRDiKeIpQiJEzDdQ5pQnhUTcB7CDiFMSS7OwARzVmCG8yn4WYTglZXR-hb6GsatgevNIrl5XmJMoXTOOAPfez90ULb6wI8M4cNhXMioBvhp4xY2g4u22yeDcqb3wQZoW_i2tdEcUo-DkzF6GGTT_YXq3jdw2ctv6y7AaS1dMJfjnIHXu9uX1TrZPN0_rBabpMuQiAlBFVeVqQtNcZWTSnGtc4UrRU0mEFZaC0oNEkRoThSljCvKa1kwyguVM0Fm4Or4t-v9x2BCLBsblHFOtsYPoWRFlhOG8F6cj-JQNUaXXW8b2X-V_yWSX007c3Q</recordid><startdate>200709</startdate><enddate>200709</enddate><creator>Brum, Doralina Guimarães</creator><creator>Barreira, Amilton Antunes</creator><creator>Louzada-Junior, Paulo</creator><creator>Mendes-Junior, Celso Teixeira</creator><creator>Donadi, Eduardo Antônio</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200709</creationdate><title>Association of the HLA-DRB115 allele group and the DRB11501 and DRB11503 alleles with multiple sclerosis in White and Mulatto samples from Brazil</title><author>Brum, Doralina Guimarães ; Barreira, Amilton Antunes ; Louzada-Junior, Paulo ; Mendes-Junior, Celso Teixeira ; Donadi, Eduardo Antônio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-30b7cbef8d51b43bc7dd4c1bc5e2901cdd955e0939d73c5567c57fa86578c4693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alleles</topic><topic>Brazil - ethnology</topic><topic>Child</topic><topic>Ethnic Groups</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Histocompatibility Testing</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DRB1 Chains</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Population Groups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brum, Doralina Guimarães</creatorcontrib><creatorcontrib>Barreira, Amilton Antunes</creatorcontrib><creatorcontrib>Louzada-Junior, Paulo</creatorcontrib><creatorcontrib>Mendes-Junior, Celso Teixeira</creatorcontrib><creatorcontrib>Donadi, Eduardo Antônio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brum, Doralina Guimarães</au><au>Barreira, Amilton Antunes</au><au>Louzada-Junior, Paulo</au><au>Mendes-Junior, Celso Teixeira</au><au>Donadi, Eduardo Antônio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of the HLA-DRB115 allele group and the DRB11501 and DRB11503 alleles with multiple sclerosis in White and Mulatto samples from Brazil</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2007-09</date><risdate>2007</risdate><volume>189</volume><issue>1-2</issue><spage>118</spage><epage>124</epage><pages>118-124</pages><issn>0165-5728</issn><abstract>Multiple sclerosis (MS) is a multifactorial inflammatory disease that primarily affects the central nervous system. Genes and environmental factors probably interact in MS susceptibility and outcome; however, their roles have not been elucidated yet. The evaluation of the HLA-DRB1 gene in the Brazilian population is of particular interest in evidencing the behavior of HLA-DRB1 alleles in a highly admixed population inserted in an environment of low MS prevalence. The present results suggest that a given HLA-DRB1 allele may exhibit different behaviors, i.e. confer resistance or susceptibility, in response to the environmental and/or genetic (ethnic) backgrounds that characterize a sampled population.</abstract><cop>Netherlands</cop><pmid>17681614</pmid><doi>10.1016/j.jneuroim.2007.06.009</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 2007-09, Vol.189 (1-2), p.118-124 |
| issn | 0165-5728 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68243601 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Alleles Brazil - ethnology Child Ethnic Groups Female Gene Frequency Genetic Predisposition to Disease Genotype Histocompatibility Testing HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Male Middle Aged Multiple Sclerosis - genetics Polymorphism, Genetic Population Groups |
| title | Association of the HLA-DRB115 allele group and the DRB11501 and DRB11503 alleles with multiple sclerosis in White and Mulatto samples from Brazil |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T17%3A41%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20the%20HLA-DRB115%20allele%20group%20and%20the%20DRB11501%20and%20DRB11503%20alleles%20with%20multiple%20sclerosis%20in%20White%20and%20Mulatto%20samples%20from%20Brazil&rft.jtitle=Journal%20of%20neuroimmunology&rft.au=Brum,%20Doralina%20Guimar%C3%A3es&rft.date=2007-09&rft.volume=189&rft.issue=1-2&rft.spage=118&rft.epage=124&rft.pages=118-124&rft.issn=0165-5728&rft_id=info:doi/10.1016/j.jneuroim.2007.06.009&rft_dat=%3Cproquest_pubme%3E68243601%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68243601&rft_id=info:pmid/17681614&rfr_iscdi=true |