Hypothermia suppresses inflammation via ERK signaling pathway in stimulated microglial cells

Abstract Hypothermic perfusion is a standard method for neuroprotection during cardiac surgery in children. However, the cellular responses underlying these mechanisms have not been clearly elucidated. In the present study we demonstrated that the inflammatory response of stimulated microglial cells...

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Veröffentlicht in:	Journal of neuroimmunology 2007-09, Vol.189 (1), p.7-16
Hauptverfasser:	Schmitt, Katharina Rose Luise, Diestel, Antje, Lehnardt, Seija, Schwartlander, Ruth, Lange, Peter E, Berger, Felix, Ullrich, Oliver, Abdul-Khaliq, Hashim
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Animals, Newborn Cardiac surgery Cell Count Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Children Cold Temperature Enzyme-Linked Immunosorbent Assay - methods Extracellular Signal-Regulated MAP Kinases - physiology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Hypothermia Inflammation Interleukin-6 - metabolism MAP-Kinases Mice Microglia - drug effects Microglia - physiology Microglial cells Neurology Nitric Oxide Synthase Type II - metabolism Polysaccharides - adverse effects Signal Transduction - drug effects Signal Transduction - physiology Tetrazolium Salts Thiazoles Time Factors Tumor Necrosis Factor-alpha - metabolism
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