DNA Cleavage Induced by Photoexcited Antimalarial Drugs: A Photophysical and Photobiological Study

ABSTRACT The interactions and the photosensitizing activity of three antimalarial drugs quinine (Q), mefloquine (MQ) and quinacrine (QC) toward DNA was studied. Evidences obtained by absorption and emission spectroscopy and by linear dichroism measurements indicate that these derivatives bind the ma...

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Veröffentlicht in:	Photochemistry and photobiology 2007-05, Vol.83 (3), p.664-674
Hauptverfasser:	Aloisi, Gian Gaetano, Amelia, Matteo, Barbafina, Arianna, Latterini, Loredana, Elisei, Fausto, Dall'Acqua, Francesco, Vedaldi, Daniela, Faccio, Anita, Viola, Giampietro
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - pharmacology Aqueous solutions Deoxyribonucleic acid DNA DNA Cleavage - drug effects DNA Cleavage - radiation effects DNA damage DNA Damage - drug effects DNA Damage - radiation effects Drugs Electron transfer Mefloquine - pharmacology Photolysis Photosensitizing Agents - pharmacology Plasmids Quinacrine - pharmacology Quinine - pharmacology
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