Dynamic water changes in excised rat myocardium assessed by continuous distribution of T1 and T2
Ischemic changes in excised rat myocardium were followed by series of T1 or T2 measurements from 1 to 60 min after isolated perfusion cessation, and the influence of manganese enhancement was investigated. An inverse Laplace transformation (ILT) of T1 or T2 data was used to resolve the number, time...
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| Veröffentlicht in: | Magnetic resonance in medicine 2007-09, Vol.58 (3), p.442-447 |
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| creator | Bruvold, Morten Seland, John Georg Brurok, Heidi Jynge, Per |
| description | Ischemic changes in excised rat myocardium were followed by series of T1 or T2 measurements from 1 to 60 min after isolated perfusion cessation, and the influence of manganese enhancement was investigated. An inverse Laplace transformation (ILT) of T1 or T2 data was used to resolve the number, time constants, and fractions of tissue water components in a continuous distribution. For T1 distributions, one single tissue component ∼900 ms was significantly shortened and dispersed by manganese enhancement (25 and 200 μM MnCl2). For T2 distributions, three tissue components (∼30, ∼100, and ∼350 ms) were obtained initially. The two shortest components merged after ∼10 min to one component (∼40 ms). Both T1 and T2 tissue components became shorter with time. In particular, the T2 distribution dynamics might be compatible with complex sequential changes in tissue water fractions during ischemia. Magn Reson Med 58:442–447, 2007. © 2007 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/mrm.21340 |
| format | Article |
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An inverse Laplace transformation (ILT) of T1 or T2 data was used to resolve the number, time constants, and fractions of tissue water components in a continuous distribution. For T1 distributions, one single tissue component ∼900 ms was significantly shortened and dispersed by manganese enhancement (25 and 200 μM MnCl2). For T2 distributions, three tissue components (∼30, ∼100, and ∼350 ms) were obtained initially. The two shortest components merged after ∼10 min to one component (∼40 ms). Both T1 and T2 tissue components became shorter with time. In particular, the T2 distribution dynamics might be compatible with complex sequential changes in tissue water fractions during ischemia. Magn Reson Med 58:442–447, 2007. © 2007 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.21340</identifier><identifier>PMID: 17763343</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Algorithms ; Animals ; Body Water - metabolism ; Chlorides - pharmacokinetics ; Extracellular Fluid - metabolism ; heart ; Heart Ventricles - metabolism ; Intracellular Fluid - metabolism ; ischemia ; longitudinal ; maganese ; Magnetic Resonance Spectroscopy ; Male ; Manganese Compounds - pharmacokinetics ; Myocardial Ischemia - metabolism ; Myocardium - metabolism ; Rats ; Rats, Wistar ; relaxation ; Time Factors ; transverse</subject><ispartof>Magnetic resonance in medicine, 2007-09, Vol.58 (3), p.442-447</ispartof><rights>Copyright © 2007 Wiley‐Liss, Inc.</rights><rights>Copyright (c) 2007 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.21340$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.21340$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17763343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bruvold, Morten</creatorcontrib><creatorcontrib>Seland, John Georg</creatorcontrib><creatorcontrib>Brurok, Heidi</creatorcontrib><creatorcontrib>Jynge, Per</creatorcontrib><title>Dynamic water changes in excised rat myocardium assessed by continuous distribution of T1 and T2</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>Ischemic changes in excised rat myocardium were followed by series of T1 or T2 measurements from 1 to 60 min after isolated perfusion cessation, and the influence of manganese enhancement was investigated. An inverse Laplace transformation (ILT) of T1 or T2 data was used to resolve the number, time constants, and fractions of tissue water components in a continuous distribution. For T1 distributions, one single tissue component ∼900 ms was significantly shortened and dispersed by manganese enhancement (25 and 200 μM MnCl2). For T2 distributions, three tissue components (∼30, ∼100, and ∼350 ms) were obtained initially. The two shortest components merged after ∼10 min to one component (∼40 ms). Both T1 and T2 tissue components became shorter with time. In particular, the T2 distribution dynamics might be compatible with complex sequential changes in tissue water fractions during ischemia. Magn Reson Med 58:442–447, 2007. © 2007 Wiley‐Liss, Inc.</description><subject>Algorithms</subject><subject>Animals</subject><subject>Body Water - metabolism</subject><subject>Chlorides - pharmacokinetics</subject><subject>Extracellular Fluid - metabolism</subject><subject>heart</subject><subject>Heart Ventricles - metabolism</subject><subject>Intracellular Fluid - metabolism</subject><subject>ischemia</subject><subject>longitudinal</subject><subject>maganese</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Manganese Compounds - pharmacokinetics</subject><subject>Myocardial Ischemia - metabolism</subject><subject>Myocardium - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>relaxation</subject><subject>Time Factors</subject><subject>transverse</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctOwzAQtBCIlseBH0A-cUvxO_ERChQkKBIUcTSO7YKhScBO1ObvSR_AkdOudmdWszMAHGE0wAiR0yIUA4IpQ1ugjzkhCeGSbYM-ShlKKJasB_ZifEcISZmyXdDDaSooZbQPXi7aUhfewLmuXYDmTZevLkJfQrcwPjoLg65h0VZGB-ubAuoYXVzO8xaaqqx92VRNhNbHOvi8qX1VwmoKJxjq0sIJOQA7Uz2L7nBT98HT1eVkeJ3c3o9uhme3ie-EoCSTFFmbE8YNFkJQTijNiMFMSImRyWyuBcuFkYjkhlo7tZLzzHa_4ZxhI-g-OFnf_QzVV-NirQofjZvNdOk6gUpkhFGC-L9AgjKeimx58XgDbPLCWfUZfKFDq37M6wCna8Dcz1z7t0dqmYrqUlGrVNTdw92q6RjJmtG55Ra_DB0-lEhpytXzeKQIH7Hx5PxKPdJvj3mNAw</recordid><startdate>200709</startdate><enddate>200709</enddate><creator>Bruvold, Morten</creator><creator>Seland, John Georg</creator><creator>Brurok, Heidi</creator><creator>Jynge, Per</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200709</creationdate><title>Dynamic water changes in excised rat myocardium assessed by continuous distribution of T1 and T2</title><author>Bruvold, Morten ; Seland, John Georg ; Brurok, Heidi ; Jynge, Per</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3340-8930ddb245c16663523382c1469910c8dba64b6c902bc3ddfd9558d1941b41c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Algorithms</topic><topic>Animals</topic><topic>Body Water - metabolism</topic><topic>Chlorides - pharmacokinetics</topic><topic>Extracellular Fluid - metabolism</topic><topic>heart</topic><topic>Heart Ventricles - metabolism</topic><topic>Intracellular Fluid - metabolism</topic><topic>ischemia</topic><topic>longitudinal</topic><topic>maganese</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Manganese Compounds - pharmacokinetics</topic><topic>Myocardial Ischemia - metabolism</topic><topic>Myocardium - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>relaxation</topic><topic>Time Factors</topic><topic>transverse</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bruvold, Morten</creatorcontrib><creatorcontrib>Seland, John Georg</creatorcontrib><creatorcontrib>Brurok, Heidi</creatorcontrib><creatorcontrib>Jynge, Per</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bruvold, Morten</au><au>Seland, John Georg</au><au>Brurok, Heidi</au><au>Jynge, Per</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic water changes in excised rat myocardium assessed by continuous distribution of T1 and T2</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>2007-09</date><risdate>2007</risdate><volume>58</volume><issue>3</issue><spage>442</spage><epage>447</epage><pages>442-447</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>Ischemic changes in excised rat myocardium were followed by series of T1 or T2 measurements from 1 to 60 min after isolated perfusion cessation, and the influence of manganese enhancement was investigated. An inverse Laplace transformation (ILT) of T1 or T2 data was used to resolve the number, time constants, and fractions of tissue water components in a continuous distribution. For T1 distributions, one single tissue component ∼900 ms was significantly shortened and dispersed by manganese enhancement (25 and 200 μM MnCl2). For T2 distributions, three tissue components (∼30, ∼100, and ∼350 ms) were obtained initially. The two shortest components merged after ∼10 min to one component (∼40 ms). Both T1 and T2 tissue components became shorter with time. 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| subjects | Algorithms Animals Body Water - metabolism Chlorides - pharmacokinetics Extracellular Fluid - metabolism heart Heart Ventricles - metabolism Intracellular Fluid - metabolism ischemia longitudinal maganese Magnetic Resonance Spectroscopy Male Manganese Compounds - pharmacokinetics Myocardial Ischemia - metabolism Myocardium - metabolism Rats Rats, Wistar relaxation Time Factors transverse |
| title | Dynamic water changes in excised rat myocardium assessed by continuous distribution of T1 and T2 |
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