Homozygous status for HLA-E0103 confers protection from acute graft-versus-host disease and transplant-related mortality in HLA-matched sibling hematopoietic stem cell transplantation

The posttransplant period following hematopoietic stem cell transplantation (HSCT) is potentially high risk for developing survival-compromising complications, many of which are known to be under the control of immunogenetic factors. Given the dual role of human leukocyte antigen (HLA)-E molecules i...

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Veröffentlicht in:	Transplantation 2006-12, Vol.82 (11), p.1436-1440
Hauptverfasser:	TAMOUZA, Ryad, BUSSON, Marc, TOUBERT, Antoine, GLUCKMAN, Eliane, CHARRON, Dominique, ROCHA, Vanderson, FORTIER, Catherine, HADDAD, Yacine, BRUN, Manuel, BOUKOUACI, Wahid, BLEUX, Hélène, SOCIE, Gérnrd, KRISHNAMOORTHY, Rajagopal
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Adult Alleles Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction Child Child, Preschool Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genotype Graft vs Host Disease - genetics Graft vs Host Disease - mortality Hematopoietic Stem Cell Transplantation Histocompatibility Antigens Class I HLA Antigens - genetics HLA-E Antigens Homozygote Humans Male Medical sciences Middle Aged Siblings Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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