Down-regulation of forkhead box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells

The Forkhead Box M1 (FoxM1) transcription factor has been shown to play important roles in regulating the expression of genes involved in cell proliferation, differentiation, and transformation. Overexpression of FoxM1 has been found in a variety of aggressive human carcinomas including pancreatic c...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-09, Vol.67 (17), p.8293-8300
Hauptverfasser:	ZHIWEI WANG, BANERJEE, Sanjeev, DEJUAN KONG, YIWEI LI, SARKAR, Fazlul H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Carcinoma - blood supply Carcinoma - genetics Carcinoma - pathology Cell Movement - genetics Cell Proliferation - drug effects Down-Regulation Forkhead Box Protein M1 Forkhead Transcription Factors - antagonists & inhibitors Forkhead Transcription Factors - genetics Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Medical sciences Neoplasm Invasiveness Neovascularization, Pathologic - genetics Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Pharmacology. Drug treatments RNA, Small Interfering - pharmacology S Phase - genetics Tumor Cells, Cultured Tumors Vascular Endothelial Growth Factor A - metabolism
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