Stereoselective pharmacokinetics of ketorolac in calves after a single intravenous and oral dose

The purpose of this study was to establish the stereospecific pharmacokinetics of ketorolac (KT) in calves following a single 2 mg/kg intravenous (i.v.) and a single 8 mg/kg oral dose. Plasma concentrations were determined using a stereoselective HPLC assay. Pharmacokinetic parameters for both the s...

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Veröffentlicht in:	Journal of veterinary pharmacology and therapeutics 2007-10, Vol.30 (5), p.437-442
Hauptverfasser:	NAGILLA, R, DESHMUKH, D.D, DURAN, S.H, RAVIS, W.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral analgesics Animals Animals, Newborn - metabolism Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Area Under Curve bioavailability blood chemistry blood plasma calves Cattle - metabolism Cross-Over Studies dosage dose response drug evaluation enantiomers half life Injections, Intravenous - veterinary intravenous injection Isomerism ketorolac Ketorolac - administration & dosage Ketorolac - blood Ketorolac - chemistry Ketorolac - pharmacokinetics Male nonsteroidal anti-inflammatory agents oral administration pharmacokinetics
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