MEK activation suppresses CPT11-induced apoptosis in rat intestinal epithelial cells through a COX-2-dependent mechanism

Resistance to chemotherapeutic agents is one of the distinct features of cancer cells. We evaluate the role of activated MEK-ERK signaling in Camptotecin/irinotecan (CPT-11)-induced cell death using constitutively activated MEK1-transfected normal rat intestinal epithelial cells (IEC-caMEK cells). A...

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Veröffentlicht in:	Digestive diseases and sciences 2007-10, Vol.52 (10), p.2757-2765
Hauptverfasser:	HORIKAWA, Youhei, OTAKA, Michiro, DUBOIS, Raymond N, WATANABE, Sumio, KOMATSU, Koga, JIN, Mario, ODASHIMA, Masaru, WADA, Isao, MATSUHASHI, Tamotsu, OHBA, Reina, OYAKE, Jinko, HATAKEYAMA, Natsumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Blotting, Western Bones, joints and connective tissue. Antiinflammatory agents Camptothecin - analogs & derivatives Camptothecin - pharmacology Cell Survival Cyclooxygenase 2 - drug effects Cyclooxygenase 2 - metabolism Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Neoplasms - metabolism Intestinal Neoplasms - pathology Medical sciences Mitogen-Activated Protein Kinase Kinases - drug effects Mitogen-Activated Protein Kinase Kinases - metabolism Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Pharmacology. Drug treatments Rats Signal Transduction Tumor Cells, Cultured
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