Phagocytes rate and cellular viability of the monocytes in patients with hepatosplenic schistosomiasis mansoni who underwent splenectomy and auto-implantation of spleen tissue
Mansonic schistosomiasis remains a medical-social issue in Northeastern Brazil. In children, surgical treatment includes splenectomy and spleen autoimplantation. This procedure reduces post-splenectomy sepsis. The aim of this study was to analyze the phagocyte rate and the cellular viability of mono...
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| Veröffentlicht in: | Revista da Sociedade Brasileira de Medicina Tropical 2006-09, Vol.39 (5), p.439-445 |
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| creator | Brandt, Carlos Teixeira de Castro, Célia Maria Machado Barbosa de Lavor, Stella Maria Lisboa de Castro, Francisco Machado Manhães |
| description | Mansonic schistosomiasis remains a medical-social issue in Northeastern Brazil. In children, surgical treatment includes splenectomy and spleen autoimplantation. This procedure reduces post-splenectomy sepsis. The aim of this study was to analyze the phagocyte rate and the cellular viability of monocytes in patients with hepatosplenic schistosomiasis, who underwent splenectomy and spleen autoimplantation from 1991 to 2001. Of the 22 individuals analyzed, 11 were patients who underwent splenectomy and spleen autoimplantation (Study group) and 11 were healthy individuals from the same region (Control group). Both groups presented similar mean age. No difference was found in the phagocyte rate between the control group (36.1%+/-4.9%) and study group (33.5%+/-5.7%). However, phagocyte viability after stimulation with lipopolysaccharide was higher (94%) in control group, when compared to the study group (65%), p |
| doi_str_mv | 10.1590/S0037-86822006000500004 |
| format | Article |
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In children, surgical treatment includes splenectomy and spleen autoimplantation. This procedure reduces post-splenectomy sepsis. The aim of this study was to analyze the phagocyte rate and the cellular viability of monocytes in patients with hepatosplenic schistosomiasis, who underwent splenectomy and spleen autoimplantation from 1991 to 2001. Of the 22 individuals analyzed, 11 were patients who underwent splenectomy and spleen autoimplantation (Study group) and 11 were healthy individuals from the same region (Control group). Both groups presented similar mean age. No difference was found in the phagocyte rate between the control group (36.1%+/-4.9%) and study group (33.5%+/-5.7%). However, phagocyte viability after stimulation with lipopolysaccharide was higher (94%) in control group, when compared to the study group (65%), p<0.001. It is possible to hypothesize that monocytes from the study group patients presented a reduced response to the microorganism challenge, in the face of a harmful and long-lasting stimulus.</description><identifier>ISSN: 0037-8682</identifier><identifier>EISSN: 1678-9849</identifier><identifier>DOI: 10.1590/S0037-86822006000500004</identifier><identifier>PMID: 17160320</identifier><language>por</language><publisher>Brazil: Sociedade Brasileira de Medicina Tropical</publisher><subject>Adolescent ; Adult ; Case-Control Studies ; Cell Survival ; Cross-Sectional Studies ; Female ; Humans ; Liver Diseases, Parasitic - immunology ; Liver Diseases, Parasitic - parasitology ; Liver Diseases, Parasitic - surgery ; Male ; Monocytes - immunology ; Monocytes - physiology ; Phagocytosis - immunology ; Phagocytosis - physiology ; Prospective Studies ; Schistosomiasis ; Schistosomiasis mansoni - immunology ; Schistosomiasis mansoni - surgery ; Spleen - immunology ; Spleen - transplantation ; Splenectomy ; Splenic Diseases - immunology ; Splenic Diseases - parasitology ; Splenic Diseases - surgery ; Transplantation, Autologous</subject><ispartof>Revista da Sociedade Brasileira de Medicina Tropical, 2006-09, Vol.39 (5), p.439-445</ispartof><rights>Copyright Sociedade Brasileira de Medicina Tropical Sep/Oct 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17160320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brandt, Carlos Teixeira</creatorcontrib><creatorcontrib>de Castro, Célia Maria Machado Barbosa</creatorcontrib><creatorcontrib>de Lavor, Stella Maria Lisboa</creatorcontrib><creatorcontrib>de Castro, Francisco Machado Manhães</creatorcontrib><title>Phagocytes rate and cellular viability of the monocytes in patients with hepatosplenic schistosomiasis mansoni who underwent splenectomy and auto-implantation of spleen tissue</title><title>Revista da Sociedade Brasileira de Medicina Tropical</title><addtitle>Rev Soc Bras Med Trop</addtitle><description>Mansonic schistosomiasis remains a medical-social issue in Northeastern Brazil. In children, surgical treatment includes splenectomy and spleen autoimplantation. This procedure reduces post-splenectomy sepsis. The aim of this study was to analyze the phagocyte rate and the cellular viability of monocytes in patients with hepatosplenic schistosomiasis, who underwent splenectomy and spleen autoimplantation from 1991 to 2001. Of the 22 individuals analyzed, 11 were patients who underwent splenectomy and spleen autoimplantation (Study group) and 11 were healthy individuals from the same region (Control group). Both groups presented similar mean age. No difference was found in the phagocyte rate between the control group (36.1%+/-4.9%) and study group (33.5%+/-5.7%). However, phagocyte viability after stimulation with lipopolysaccharide was higher (94%) in control group, when compared to the study group (65%), p<0.001. It is possible to hypothesize that monocytes from the study group patients presented a reduced response to the microorganism challenge, in the face of a harmful and long-lasting stimulus.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Cell Survival</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Diseases, Parasitic - immunology</subject><subject>Liver Diseases, Parasitic - parasitology</subject><subject>Liver Diseases, Parasitic - surgery</subject><subject>Male</subject><subject>Monocytes - immunology</subject><subject>Monocytes - physiology</subject><subject>Phagocytosis - immunology</subject><subject>Phagocytosis - physiology</subject><subject>Prospective Studies</subject><subject>Schistosomiasis</subject><subject>Schistosomiasis mansoni - immunology</subject><subject>Schistosomiasis mansoni - surgery</subject><subject>Spleen - immunology</subject><subject>Spleen - 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Academic</collection><jtitle>Revista da Sociedade Brasileira de Medicina Tropical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brandt, Carlos Teixeira</au><au>de Castro, Célia Maria Machado Barbosa</au><au>de Lavor, Stella Maria Lisboa</au><au>de Castro, Francisco Machado Manhães</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phagocytes rate and cellular viability of the monocytes in patients with hepatosplenic schistosomiasis mansoni who underwent splenectomy and auto-implantation of spleen tissue</atitle><jtitle>Revista da Sociedade Brasileira de Medicina Tropical</jtitle><addtitle>Rev Soc Bras Med Trop</addtitle><date>2006-09</date><risdate>2006</risdate><volume>39</volume><issue>5</issue><spage>439</spage><epage>445</epage><pages>439-445</pages><issn>0037-8682</issn><eissn>1678-9849</eissn><abstract>Mansonic schistosomiasis remains a medical-social issue in Northeastern Brazil. In children, surgical treatment includes splenectomy and spleen autoimplantation. This procedure reduces post-splenectomy sepsis. The aim of this study was to analyze the phagocyte rate and the cellular viability of monocytes in patients with hepatosplenic schistosomiasis, who underwent splenectomy and spleen autoimplantation from 1991 to 2001. Of the 22 individuals analyzed, 11 were patients who underwent splenectomy and spleen autoimplantation (Study group) and 11 were healthy individuals from the same region (Control group). Both groups presented similar mean age. No difference was found in the phagocyte rate between the control group (36.1%+/-4.9%) and study group (33.5%+/-5.7%). However, phagocyte viability after stimulation with lipopolysaccharide was higher (94%) in control group, when compared to the study group (65%), p<0.001. It is possible to hypothesize that monocytes from the study group patients presented a reduced response to the microorganism challenge, in the face of a harmful and long-lasting stimulus.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Medicina Tropical</pub><pmid>17160320</pmid><doi>10.1590/S0037-86822006000500004</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Revista da Sociedade Brasileira de Medicina Tropical, 2006-09, Vol.39 (5), p.439-445 |
| issn | 0037-8682 1678-9849 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Case-Control Studies Cell Survival Cross-Sectional Studies Female Humans Liver Diseases, Parasitic - immunology Liver Diseases, Parasitic - parasitology Liver Diseases, Parasitic - surgery Male Monocytes - immunology Monocytes - physiology Phagocytosis - immunology Phagocytosis - physiology Prospective Studies Schistosomiasis Schistosomiasis mansoni - immunology Schistosomiasis mansoni - surgery Spleen - immunology Spleen - transplantation Splenectomy Splenic Diseases - immunology Splenic Diseases - parasitology Splenic Diseases - surgery Transplantation, Autologous |
| title | Phagocytes rate and cellular viability of the monocytes in patients with hepatosplenic schistosomiasis mansoni who underwent splenectomy and auto-implantation of spleen tissue |
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