Lovastatin possesses a fungistatic effect against Candida albicans, but does not trigger apoptosis in this opportunistic human pathogen
Lovastatin inhibited the growth of Candida albicans in a fungistatic way. Although it triggers apoptosis in a great variety of eukaryotic cells, including many tumour cell lines, lovastatin failed to provoke apoptotic events in this human pathogen. The fungistatic behaviour of this statin might aris...
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| Veröffentlicht in: | FEMS yeast research 2006-12, Vol.6 (8), p.1140-1148 |
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| container_title | FEMS yeast research |
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| creator | Gyetvai, Ágnes Emri, Tamás Takács, Krisztina Dergez, Tímea Fekete, Andrea Pesti, Miklós Pócsi, István Lenkey, Béla |
| description | Lovastatin inhibited the growth of Candida albicans in a fungistatic way. Although it triggers apoptosis in a great variety of eukaryotic cells, including many tumour cell lines, lovastatin failed to provoke apoptotic events in this human pathogen. The fungistatic behaviour of this statin might arise from its negative influence on membrane fluidity. Because yeast[rightward arrow]pseudomycelium and hyphae morphogenetic transitions took place under exposure to lovastatin morphogenetic switch and apoptotic cell death must be regulated independently in C. albicans. |
| doi_str_mv | 10.1111/j.1567-1364.2006.00097.x |
| format | Article |
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Although it triggers apoptosis in a great variety of eukaryotic cells, including many tumour cell lines, lovastatin failed to provoke apoptotic events in this human pathogen. The fungistatic behaviour of this statin might arise from its negative influence on membrane fluidity. 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| ispartof | FEMS yeast research, 2006-12, Vol.6 (8), p.1140-1148 |
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| source | Oxford Journals Open Access Collection; MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Antifungal Agents - pharmacology Apoptosis Apoptosis - drug effects Candida albicans Candida albicans - drug effects Candida albicans - growth & development candidiasis Cell death Cell Membrane - drug effects Cell Membrane - metabolism chemotherapy DNA Fragmentation - drug effects DNA, Fungal - drug effects Fluidity Humans Hyphae Lovastatin Lovastatin - pharmacology Membrane fluidity Opportunist infection Pathogens pseudomycelium Tumor cell lines Tumors |
| title | Lovastatin possesses a fungistatic effect against Candida albicans, but does not trigger apoptosis in this opportunistic human pathogen |
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