Tumor necrosis factor alpha alters Na+-K+ ATPase activity in rat cardiac myocytes: involvement of NF-kappaB, AP-1 and PGE2

There has been increasing evidence that tumor necrosis factor alpha (TNF-alpha) is synthesized by cardiomyoctes and contributes to their impaired function and to cardiac failure. Because the Na(+)-K(+) ATPase is a key player in the contraction of cardiomyocytes, this work was undertaken to study the...

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Veröffentlicht in:	Life sciences (1973) 2006-12, Vol.80 (2), p.173-180
Hauptverfasser:	Skayian, Yester, Kreydiyyeh, Sawsan Ibrahim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Curcumin - pharmacology Cyclooxygenase Inhibitors - pharmacology Dinoprostone - pharmacology Dinoprostone - physiology Dose-Response Relationship, Drug Indomethacin - pharmacology Male Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Myocytes, Cardiac - metabolism NF-kappa B - antagonists & inhibitors NF-kappa B - physiology Proline - analogs & derivatives Proline - pharmacology Rats Rats, Sprague-Dawley Sodium-Potassium-Exchanging ATPase - metabolism Thiocarbamates - pharmacology Transcription Factor AP-1 - antagonists & inhibitors Transcription Factor AP-1 - physiology Tumor Necrosis Factor-alpha - pharmacology
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