Sequence-Dependent Binding of Dipeptides by an Artificial Receptor in Water

An artificial dipeptide receptor (1) was designed and observed to bind the deprotonated dipeptide Ac‐D‐Ala‐D‐Ala‐OH in buffered water with K = 33 100 m−1, whereas other dipeptides such as Ac‐Gly‐Gly‐OH or Ac‐D‐Val‐D‐Val‐OH were bound less efficiently, by factors of more than 10 (K < 3000 m−1). Th...

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Veröffentlicht in:	Chemistry : a European journal 2006-12, Vol.12 (36), p.9186-9195
Hauptverfasser:	Schmuck, Carsten, Rupprecht, Daniel, Wienand, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	artificial receptors Binding Sites Dipeptides - chemistry Dipeptides - metabolism guanidinium cations Hydrogen Bonding Magnetic Resonance Spectroscopy Mass Spectrometry molecular recognition peptides Protein Binding Spectrometry, Fluorescence Spectrophotometry, Ultraviolet supramolecular chemistry Water - chemistry
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