IFN-gamma and R-848 dependent activation of human monocyte-derived dendritic cells by Neisseria meningitidis adhesin A

A soluble recombinant form of Neisseria meningitidis adhesin A (NadADelta351-405), proposed as a constituent of anti-meningococcal B vaccines, is here shown to specifically interact with and immune-modulate human monocyte-derived dendritic cells (mo-DCs). After priming with IFN-gamma and stimulation...

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Veröffentlicht in:	Journal of Immunology 2007-09, Vol.179 (6), p.3904-3916
Hauptverfasser:	Mazzon, Cristina, Baldani-Guerra, Barbara, Cecchini, Paola, Kasic, Tihana, Viola, Antonella, de Bernard, Marina, Aricò, Beatrice, Gerosa, Franca, Papini, Emanuele
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - genetics Adhesins, Bacterial - metabolism Animals Cell Line CHO Cells Cricetinae Cricetulus Cytokines - biosynthesis Cytokines - genetics Cytokines - metabolism Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - microbiology Flagellin - pharmacology Humans Imidazoles - pharmacology Interferon-gamma - physiology Lipopolysaccharides - pharmacology Monocytes - cytology Monocytes - metabolism Neisseria meningitidis Neisseria meningitidis - immunology Oligodeoxyribonucleotides - pharmacology Protein Binding - immunology Transcriptional Activation - immunology
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