Serum iron increases with acute induction of hepatic heme oxygenase-1 in mice

Heme oxygenase (HO)-1 is induced by oxidative stress and protects against oxidant injury. We examined the effect of rapid induction of hepatic HO-1 on serum iron level. Serum iron was approximately doubled within 6 h when HO-1 was induced by phenobarbital treatment of selenium-deficient mice. Blocki...

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Veröffentlicht in:	Drug metabolism reviews 2007-01, Vol.39 (2-3), p.619-626
Hauptverfasser:	MOSTERT, Volker, NAKAYAMA, Akihiro, AUSTIN, Lori M, LEVANDER, Ximena A, FERRIS, Christopher D, HILL, Kristina E, BURK, Raymond F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Dihydropyridines - pharmacology Enzyme Induction - drug effects Enzyme Induction - physiology Heme - antagonists & inhibitors Heme - biosynthesis Heme Oxygenase-1 - biosynthesis Iron - blood Liver - drug effects Liver - enzymology Male Medical sciences Mice Mice, Inbred C57BL Pharmacology. Drug treatments Selenium - deficiency
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