Prolonged Prevention of Squamous Cell Carcinoma of the Skin by Regular Sunscreen Use
Half of all cancers in the United States are skin cancers. We have previously shown in a 4.5-year randomized controlled trial in an Australian community that squamous cell carcinomas (SCC) but not basal cell carcinomas (BCC) can be prevented by regular sunscreen application to the head, neck, hands,...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2006-12, Vol.15 (12), p.2546-2548 |
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| container_title | Cancer epidemiology, biomarkers & prevention |
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| creator | VAN DER POLS, Jolieke C WILLIAMS, Gail M PANDEYA, Nirmala LOGAN, Valerie GREEN, Adèle C |
| description | Half of all cancers in the United States are skin cancers. We have previously shown in a 4.5-year randomized controlled trial
in an Australian community that squamous cell carcinomas (SCC) but not basal cell carcinomas (BCC) can be prevented by regular
sunscreen application to the head, neck, hands, and forearms. Since cessation of the trial, we have followed participants
for a further 8 years to evaluate possible latency of preventive effect on BCCs and SCCs. After prolonged follow-up, BCC tumor
rates tended to decrease but not significantly in people formerly randomized to daily sunscreen use compared with those not
applying sunscreen daily. By contrast, corresponding SCC tumor rates were significantly decreased by almost 40% during the
entire follow-up period (rate ratio, 0.62; 95% confidence interval, 0.38-0.99). Regular application of sunscreen has prolonged
preventive effects on SCC but with no clear benefit in reducing BCC. (Cancer Epidemiol Biomarkers Prev 2006;15(12):2546–8) |
| doi_str_mv | 10.1158/1055-9965.EPI-06-0352 |
| format | Article |
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in an Australian community that squamous cell carcinomas (SCC) but not basal cell carcinomas (BCC) can be prevented by regular
sunscreen application to the head, neck, hands, and forearms. Since cessation of the trial, we have followed participants
for a further 8 years to evaluate possible latency of preventive effect on BCCs and SCCs. After prolonged follow-up, BCC tumor
rates tended to decrease but not significantly in people formerly randomized to daily sunscreen use compared with those not
applying sunscreen daily. By contrast, corresponding SCC tumor rates were significantly decreased by almost 40% during the
entire follow-up period (rate ratio, 0.62; 95% confidence interval, 0.38-0.99). Regular application of sunscreen has prolonged
preventive effects on SCC but with no clear benefit in reducing BCC. (Cancer Epidemiol Biomarkers Prev 2006;15(12):2546–8)</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-06-0352</identifier><identifier>PMID: 17132769</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Australia - epidemiology ; Behavioral Prevention Research ; Biological and medical sciences ; cancer prevention ; Carcinoma, Basal Cell - epidemiology ; Carcinoma, Basal Cell - prevention & control ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - prevention & control ; community based randomised trial ; Dermatology ; Follow-Up Studies ; Humans ; Medical sciences ; Melanoma/skin cancers ; Skin Neoplasms - epidemiology ; Skin Neoplasms - prevention & control ; Sunscreening Agents - therapeutic use ; Tropical medicine ; Tumors ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2006-12, Vol.15 (12), p.2546-2548</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-5f624894b1f1320cb56f0853fe5a022ad975988c1adcd4d602da0389c4ac4b1e3</citedby><cites>FETCH-LOGICAL-c468t-5f624894b1f1320cb56f0853fe5a022ad975988c1adcd4d602da0389c4ac4b1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3356,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18363130$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17132769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN DER POLS, Jolieke C</creatorcontrib><creatorcontrib>WILLIAMS, Gail M</creatorcontrib><creatorcontrib>PANDEYA, Nirmala</creatorcontrib><creatorcontrib>LOGAN, Valerie</creatorcontrib><creatorcontrib>GREEN, Adèle C</creatorcontrib><title>Prolonged Prevention of Squamous Cell Carcinoma of the Skin by Regular Sunscreen Use</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Half of all cancers in the United States are skin cancers. We have previously shown in a 4.5-year randomized controlled trial
in an Australian community that squamous cell carcinomas (SCC) but not basal cell carcinomas (BCC) can be prevented by regular
sunscreen application to the head, neck, hands, and forearms. Since cessation of the trial, we have followed participants
for a further 8 years to evaluate possible latency of preventive effect on BCCs and SCCs. After prolonged follow-up, BCC tumor
rates tended to decrease but not significantly in people formerly randomized to daily sunscreen use compared with those not
applying sunscreen daily. By contrast, corresponding SCC tumor rates were significantly decreased by almost 40% during the
entire follow-up period (rate ratio, 0.62; 95% confidence interval, 0.38-0.99). Regular application of sunscreen has prolonged
preventive effects on SCC but with no clear benefit in reducing BCC. (Cancer Epidemiol Biomarkers Prev 2006;15(12):2546–8)</description><subject>Australia - epidemiology</subject><subject>Behavioral Prevention Research</subject><subject>Biological and medical sciences</subject><subject>cancer prevention</subject><subject>Carcinoma, Basal Cell - epidemiology</subject><subject>Carcinoma, Basal Cell - prevention & control</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - prevention & control</subject><subject>community based randomised trial</subject><subject>Dermatology</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Melanoma/skin cancers</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Skin Neoplasms - prevention & control</subject><subject>Sunscreening Agents - therapeutic use</subject><subject>Tropical medicine</subject><subject>Tumors</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1r2zAUhsVYWdt0P2FDNyvswqk-fGTpcoRsLRQamvZaKPJx4s2WWynu6L-vTDJ6uSsJ9LznvDwi5Atnc85BX3EGUBijYL5c3RRMFUyC-EDOOEhdVBXAx3z_x5yS85R-M8YqA_CJnPKKS1Epc0YeVnHohrDFmq4ivmDYt0OgQ0PXz6PrhzHRBXYdXbjo2zD0bnra75Cu_7SBbl7pPW7HzkW6HkPyETHQx4QX5KRxXcLPx3NGHn8uHxbXxe3dr5vFj9vCl0rvC2iUKLUpN7zJdZjfgGqYBtkgOCaEq00FRmvPXe3rslZM1I5JbXzpfA6hnJHLw9ynODyPmPa2b5PPfV3AXN0qLSRABf8FuQGmlBQZhAPo45BSxMY-xbZ38dVyZifvdnJqJ6c2e7dM2cl7zn09Lhg3PdbvqaPoDHw7Ai551zXRBd-md05LJblkmft-4Hbtdve3jWh9JjFGTJj_YGc5WC6sgFLJN06YmNM</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>VAN DER POLS, Jolieke C</creator><creator>WILLIAMS, Gail M</creator><creator>PANDEYA, Nirmala</creator><creator>LOGAN, Valerie</creator><creator>GREEN, Adèle C</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Prolonged Prevention of Squamous Cell Carcinoma of the Skin by Regular Sunscreen Use</title><author>VAN DER POLS, Jolieke C ; WILLIAMS, Gail M ; PANDEYA, Nirmala ; LOGAN, Valerie ; GREEN, Adèle C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-5f624894b1f1320cb56f0853fe5a022ad975988c1adcd4d602da0389c4ac4b1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Australia - epidemiology</topic><topic>Behavioral Prevention Research</topic><topic>Biological and medical sciences</topic><topic>cancer prevention</topic><topic>Carcinoma, Basal Cell - epidemiology</topic><topic>Carcinoma, Basal Cell - prevention & control</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - prevention & control</topic><topic>community based randomised trial</topic><topic>Dermatology</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Melanoma/skin cancers</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Skin Neoplasms - prevention & control</topic><topic>Sunscreening Agents - therapeutic use</topic><topic>Tropical medicine</topic><topic>Tumors</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN DER POLS, Jolieke C</creatorcontrib><creatorcontrib>WILLIAMS, Gail M</creatorcontrib><creatorcontrib>PANDEYA, Nirmala</creatorcontrib><creatorcontrib>LOGAN, Valerie</creatorcontrib><creatorcontrib>GREEN, Adèle C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAN DER POLS, Jolieke C</au><au>WILLIAMS, Gail M</au><au>PANDEYA, Nirmala</au><au>LOGAN, Valerie</au><au>GREEN, Adèle C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolonged Prevention of Squamous Cell Carcinoma of the Skin by Regular Sunscreen Use</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>15</volume><issue>12</issue><spage>2546</spage><epage>2548</epage><pages>2546-2548</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Half of all cancers in the United States are skin cancers. We have previously shown in a 4.5-year randomized controlled trial
in an Australian community that squamous cell carcinomas (SCC) but not basal cell carcinomas (BCC) can be prevented by regular
sunscreen application to the head, neck, hands, and forearms. Since cessation of the trial, we have followed participants
for a further 8 years to evaluate possible latency of preventive effect on BCCs and SCCs. After prolonged follow-up, BCC tumor
rates tended to decrease but not significantly in people formerly randomized to daily sunscreen use compared with those not
applying sunscreen daily. By contrast, corresponding SCC tumor rates were significantly decreased by almost 40% during the
entire follow-up period (rate ratio, 0.62; 95% confidence interval, 0.38-0.99). Regular application of sunscreen has prolonged
preventive effects on SCC but with no clear benefit in reducing BCC. (Cancer Epidemiol Biomarkers Prev 2006;15(12):2546–8)</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>17132769</pmid><doi>10.1158/1055-9965.EPI-06-0352</doi><tpages>3</tpages></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2006-12, Vol.15 (12), p.2546-2548 |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Australia - epidemiology Behavioral Prevention Research Biological and medical sciences cancer prevention Carcinoma, Basal Cell - epidemiology Carcinoma, Basal Cell - prevention & control Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - prevention & control community based randomised trial Dermatology Follow-Up Studies Humans Medical sciences Melanoma/skin cancers Skin Neoplasms - epidemiology Skin Neoplasms - prevention & control Sunscreening Agents - therapeutic use Tropical medicine Tumors Tumors of the skin and soft tissue. Premalignant lesions |
| title | Prolonged Prevention of Squamous Cell Carcinoma of the Skin by Regular Sunscreen Use |
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