Abdominal adiposity and the polycystic ovary syndrome
Abdominal adiposity, overweightness and obesity are frequently present in patients with polycystic ovary syndrome (PCOS). A large body of evidence suggests that abdominal adiposity and the resulting insulin resistance contribute to ovarian and, possibly, adrenal hyperandrogenism. However, androgen e...
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| Veröffentlicht in: | Trends in endocrinology and metabolism 2007-09, Vol.18 (7), p.266-272 |
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| creator | Escobar-Morreale, Héctor F Millán, José L. San |
| description | Abdominal adiposity, overweightness and obesity are frequently present in patients with polycystic ovary syndrome (PCOS). A large body of evidence suggests that abdominal adiposity and the resulting insulin resistance contribute to ovarian and, possibly, adrenal hyperandrogenism. However, androgen excess itself might also contribute to abdominal fat deposition in hyperandrogenic women. Recent genomic and proteomic analyses of visceral fat from PCOS patients have detected differences in gene expression and protein content compared with those of non-hyperandrogenic women. Here we review the existing evidence for a vicious circle whereby androgen excess favoring the abdominal deposition of fat further facilitates androgen secretion by the ovaries and adrenals in PCOS patients. |
| doi_str_mv | 10.1016/j.tem.2007.07.003 |
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| fulltext | fulltext |
| identifier | ISSN: 1043-2760 |
| ispartof | Trends in endocrinology and metabolism, 2007-09, Vol.18 (7), p.266-272 |
| issn | 1043-2760 1879-3061 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Abdominal Fat - metabolism Abdominal Fat - physiopathology Adiposity Endocrinology & Metabolism Female Humans Hyperandrogenism - complications Hyperandrogenism - physiopathology Hyperinsulinism - complications Hyperinsulinism - physiopathology Insulin Resistance - physiology Leptin - metabolism Models, Biological Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - metabolism Polycystic Ovary Syndrome - physiopathology |
| title | Abdominal adiposity and the polycystic ovary syndrome |
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