Involvement of Drosophila Sir2-like genes in the regulation of life span
In Drosophila melanogaster, the Sir2 gene and four Sir2-like genes have been found to be homologous to yeast SIR2 genes. To examine whether the fly Sir2, CG5216, and two Sir2-like genes, CG5085 and CG6284, affect life span, we suppressed their expression using RNAi. Decreased expression of the Sir2...
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| Veröffentlicht in: | Genes & Genetic Systems 2006, Vol.81(5), pp.341-348 |
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| creator | Kusama, S.(Ochanomizu Univ., Tokyo (Japan)) Ueda, R Suda, T Nishihara, S Matsuura, E.T |
| description | In Drosophila melanogaster, the Sir2 gene and four Sir2-like genes have been found to be homologous to yeast SIR2 genes. To examine whether the fly Sir2, CG5216, and two Sir2-like genes, CG5085 and CG6284, affect life span, we suppressed their expression using RNAi. Decreased expression of the Sir2 and Sir2-like genes in all cells caused lethality during development. Suppression of the Sir2 in neurons and ubiquitous silencing of the Sir2-like genes shortened life spans. The effects were severer at 28°C than at 25°C. These results suggest that Sir2-like genes as well as Sir2 are involved in the regulation of life span in Drosophila. |
| doi_str_mv | 10.1266/ggs.81.341 |
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To examine whether the fly Sir2, CG5216, and two Sir2-like genes, CG5085 and CG6284, affect life span, we suppressed their expression using RNAi. Decreased expression of the Sir2 and Sir2-like genes in all cells caused lethality during development. Suppression of the Sir2 in neurons and ubiquitous silencing of the Sir2-like genes shortened life spans. The effects were severer at 28°C than at 25°C. 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Syst.</addtitle><description>In Drosophila melanogaster, the Sir2 gene and four Sir2-like genes have been found to be homologous to yeast SIR2 genes. To examine whether the fly Sir2, CG5216, and two Sir2-like genes, CG5085 and CG6284, affect life span, we suppressed their expression using RNAi. Decreased expression of the Sir2 and Sir2-like genes in all cells caused lethality during development. Suppression of the Sir2 in neurons and ubiquitous silencing of the Sir2-like genes shortened life spans. The effects were severer at 28°C than at 25°C. These results suggest that Sir2-like genes as well as Sir2 are involved in the regulation of life span in Drosophila.</description><subject>Animals</subject><subject>Drosophila</subject><subject>DROSOPHILA MELANOGASTER</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - physiology</subject><subject>Drosophila Proteins - genetics</subject><subject>EXPRESION GENICA</subject><subject>EXPRESSION DES GENES</subject><subject>GENE</subject><subject>GENE EXPRESSION</subject><subject>GENES</subject><subject>Histone Deacetylases - genetics</subject><subject>life span</subject><subject>LONGEVIDAD</subject><subject>LONGEVITE</subject><subject>LONGEVITY</subject><subject>Longevity - genetics</subject><subject>RNAi</subject><subject>Sir2</subject><subject>Sir2-like</subject><subject>Sirtuins - genetics</subject><issn>1341-7568</issn><issn>1880-5779</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c2L1DAYBvAgivuhF-9KQfAgdMxH83USWVd3ZUFBPYc0fdvJmEnGpF3wvzdLxxW8eElC8uOBPC9CzwjeECrEm2kqG0U2rCMP0ClRCrdcSv2wnutVK7lQJ-islB3GFGvFHqMTIgnXVPNTdHUdb1O4hT3EuUlj8z6nkg5bH2zz1WfaBv8DmgkilMbHZt5Ck2Fagp19inc--BGacrDxCXo02lDg6XE_R98_XH67uGpvPn-8vnh30zqBxdz2cnBO92PX95wIDpwNMGgQlIwjlkJgp3reA8GODJwCdFy7TjE8DJRJqx07R6_W3ENOPxcos9n74iAEGyEtxQhFWScE_S8kWijMJa7w5T9wl5Yc6ycM6UTHOs4oqer1qlxtqGQYzSH7vc2_DMHmbgymjsEoYmrnFb84Ri79Hoa_9Nh7BW9XsCuzneAe2Dx7F-BPFl-XGnn_4rY2G4g14fmaMNpk7JR9MZ--UIwlxlxzyn4DDzahig</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Kusama, S.(Ochanomizu Univ., Tokyo (Japan))</creator><creator>Ueda, R</creator><creator>Suda, T</creator><creator>Nishihara, S</creator><creator>Matsuura, E.T</creator><general>The Genetics Society of Japan</general><general>Japan Science and Technology Agency</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Involvement of Drosophila Sir2-like genes in the regulation of life span</title><author>Kusama, S.(Ochanomizu Univ., Tokyo (Japan)) ; Ueda, R ; Suda, T ; Nishihara, S ; Matsuura, E.T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c606t-b7dcc9bf4bb5165e53ded9e621ff07660c8b5be10c1d52ee459c4830dd237a9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Drosophila</topic><topic>DROSOPHILA MELANOGASTER</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila melanogaster - physiology</topic><topic>Drosophila Proteins - genetics</topic><topic>EXPRESION GENICA</topic><topic>EXPRESSION DES GENES</topic><topic>GENE</topic><topic>GENE EXPRESSION</topic><topic>GENES</topic><topic>Histone Deacetylases - genetics</topic><topic>life span</topic><topic>LONGEVIDAD</topic><topic>LONGEVITE</topic><topic>LONGEVITY</topic><topic>Longevity - genetics</topic><topic>RNAi</topic><topic>Sir2</topic><topic>Sir2-like</topic><topic>Sirtuins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kusama, S.(Ochanomizu Univ., Tokyo (Japan))</creatorcontrib><creatorcontrib>Ueda, R</creatorcontrib><creatorcontrib>Suda, T</creatorcontrib><creatorcontrib>Nishihara, S</creatorcontrib><creatorcontrib>Matsuura, E.T</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genes & Genetic Systems</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kusama, S.(Ochanomizu Univ., Tokyo (Japan))</au><au>Ueda, R</au><au>Suda, T</au><au>Nishihara, S</au><au>Matsuura, E.T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of Drosophila Sir2-like genes in the regulation of life span</atitle><jtitle>Genes & Genetic Systems</jtitle><addtitle>Genes Genet. 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| ispartof | Genes & Genetic Systems, 2006, Vol.81(5), pp.341-348 |
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| subjects | Animals Drosophila DROSOPHILA MELANOGASTER Drosophila melanogaster - genetics Drosophila melanogaster - physiology Drosophila Proteins - genetics EXPRESION GENICA EXPRESSION DES GENES GENE GENE EXPRESSION GENES Histone Deacetylases - genetics life span LONGEVIDAD LONGEVITE LONGEVITY Longevity - genetics RNAi Sir2 Sir2-like Sirtuins - genetics |
| title | Involvement of Drosophila Sir2-like genes in the regulation of life span |
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