Characteristics of dimeric (bis) bidentate selective high affinity ligands as HLA-DR10 beta antibody mimics targeting non-Hodgkin's lymphoma

Despite their large size, antibodies have proven to be suitable radioisotope carriers to deliver systemic radiotherapy, often molecular image-based, for lymphoma and leukemia. To mimic antibody (Ab) targeting behavior while decreasing size by 50-100x, a combination of computational and experimental...

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Veröffentlicht in:	International journal of oncology 2007-10, Vol.31 (4), p.729-740
Hauptverfasser:	DeNardo, Gerald L, Hok, Saphon, Van Natarajan, Arutselvan, Cosman, Monique, DeNardo, Sally J, Lightstone, Felice C, Mirick, Gary R, Yuan, Aina, Perkins, Julie, Sysko, Vladimir V, Lehmann, Joerg, Balhorn, Rodney L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - metabolism Antibodies, Monoclonal, Murine-Derived Enzyme-Linked Immunosorbent Assay Female HLA-DR Antigens - immunology HLA-DR Antigens - metabolism HLA-DR Serological Subtypes Humans Ligands Lymphoma, Non-Hodgkin - diagnostic imaging Lymphoma, Non-Hodgkin - radiotherapy Mice Mice, Inbred BALB C Mice, Nude Molecular Mimicry Molecular Structure Peptide Fragments - chemical synthesis Peptide Fragments - immunology Peptide Fragments - metabolism Radioimmunotherapy Radionuclide Imaging Radiopharmaceuticals - pharmacokinetics Transplantation, Heterologous
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