Hepatic steatosis in chronic hepatitis B develops due to host metabolic factors: A comparative approach with genotype 1 chronic hepatitis C
Abstract Background/aims Hepatic steatosis has not been adequately studied in chronic hepatitis B, while it is considered to be a cardinal feature in chronic hepatitis C and to be mainly metabolically induced in patients infected with genotype 1. We investigated the prevalence of and the parameters...
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| Veröffentlicht in: | Digestive and liver disease 2007-10, Vol.39 (10), p.936-942 |
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| creator | Tsochatzis, E Papatheodoridis, G.V Manesis, E.K Chrysanthos, N Kafiri, G Archimandritis, A.J |
| description | Abstract Background/aims Hepatic steatosis has not been adequately studied in chronic hepatitis B, while it is considered to be a cardinal feature in chronic hepatitis C and to be mainly metabolically induced in patients infected with genotype 1. We investigated the prevalence of and the parameters associated with steatosis in HBeAg-negative chronic hepatitis B. Methods We studied 213 patients with HBeAg-negative chronic hepatitis B and compared them with 163 patients with genotype-1 chronic hepatitis C. Steatosis was semi-quantitatively graded. Results Steatosis was significantly less frequent in chronic hepatitis B than chronic hepatitis C (60% versus 72%, P = 0.016), but there was no difference in the prevalence of moderate/severe steatosis. In chronic hepatitis B, steatosis was associated only with higher body mass index ( P = 0.002), while moderate/severe steatosis was associated only with higher body mass index ( P = 0.043) and diabetes ( P = 0.031). Steatosis was relatively less frequent in chronic hepatitis B than chronic hepatitis C non-diabetic, normal-weight patients (45.6% versus 62.5%, P = 0.063), but it did not differ in diabetic and/or overweight/obese patients with chronic hepatitis B or chronic hepatitis C. Conclusions Hepatic steatosis in HBeAg-negative chronic hepatitis B (a) is less frequent than in genotype-1 chronic hepatitis C, (b) is mainly associated with presence of host metabolic factors, such as high body mass index and diabetes and (c) does not seem to be associated with the severity of liver histological lesions. |
| doi_str_mv | 10.1016/j.dld.2007.07.151 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68232503</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1590865807004380</els_id><sourcerecordid>68232503</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-10c19c10757bd4ffdef2cbc02d891b4444d6511715452461624a4ac3c7f09d33</originalsourceid><addsrcrecordid>eNp9Ul2r1DAQLaJ4P_QH-CJ58q3rJG2SroJwXa5e4YIP3veQJlObtW1qkq7sb_BPm7oLgohhIMPknJNkzhTFCwobClS83m_sYDcMQG5yUE4fFZe0kU1ZccEe55xvoWwEby6Kqxj3AIwKDk-LCyolA1HJy-LnHc46OUNiQp18dJG4iZg--CkX-9-HKRffE4sHHPwciV2QJE96HxMZMenWDxnaaZN8iG_IDTF-nHXIxAMSPc_Ba9OTHy715CtOPh1nJPQfV-yeFU86PUR8ft6vi4cPtw-7u_L-88dPu5v70tQgUknB0K2hILlsbd11FjtmWgPMNlva1nlZwSmVlNec1YIKVutam8rIDra2qq6LVyfZ_LLvC8akRhcNDoOe0C9RiYZVjMMKpCegCT7GgJ2agxt1OCoKajVA7VU2QK0GqBzZgMx5eRZf2hHtH8a54xnw9gTA_MODw6CicTgZtC6gScp691_5d3-xzeByG_XwDY8Y934JU26doioyBerLOgHrAIAEqKsGql_Dm6yB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68232503</pqid></control><display><type>article</type><title>Hepatic steatosis in chronic hepatitis B develops due to host metabolic factors: A comparative approach with genotype 1 chronic hepatitis C</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Tsochatzis, E ; Papatheodoridis, G.V ; Manesis, E.K ; Chrysanthos, N ; Kafiri, G ; Archimandritis, A.J</creator><creatorcontrib>Tsochatzis, E ; Papatheodoridis, G.V ; Manesis, E.K ; Chrysanthos, N ; Kafiri, G ; Archimandritis, A.J</creatorcontrib><description>Abstract Background/aims Hepatic steatosis has not been adequately studied in chronic hepatitis B, while it is considered to be a cardinal feature in chronic hepatitis C and to be mainly metabolically induced in patients infected with genotype 1. We investigated the prevalence of and the parameters associated with steatosis in HBeAg-negative chronic hepatitis B. Methods We studied 213 patients with HBeAg-negative chronic hepatitis B and compared them with 163 patients with genotype-1 chronic hepatitis C. Steatosis was semi-quantitatively graded. Results Steatosis was significantly less frequent in chronic hepatitis B than chronic hepatitis C (60% versus 72%, P = 0.016), but there was no difference in the prevalence of moderate/severe steatosis. In chronic hepatitis B, steatosis was associated only with higher body mass index ( P = 0.002), while moderate/severe steatosis was associated only with higher body mass index ( P = 0.043) and diabetes ( P = 0.031). Steatosis was relatively less frequent in chronic hepatitis B than chronic hepatitis C non-diabetic, normal-weight patients (45.6% versus 62.5%, P = 0.063), but it did not differ in diabetic and/or overweight/obese patients with chronic hepatitis B or chronic hepatitis C. Conclusions Hepatic steatosis in HBeAg-negative chronic hepatitis B (a) is less frequent than in genotype-1 chronic hepatitis C, (b) is mainly associated with presence of host metabolic factors, such as high body mass index and diabetes and (c) does not seem to be associated with the severity of liver histological lesions.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2007.07.151</identifier><identifier>PMID: 17720637</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Biopsy ; Body Mass Index ; Chronic hepatitis B ; Chronic hepatitis C ; Diabetes Complications - complications ; Diabetes Complications - metabolism ; DNA, Viral - genetics ; Fatty Liver - epidemiology ; Fatty Liver - etiology ; Fatty Liver - metabolism ; Female ; Gastroenterology and Hepatology ; Genotype ; Hepacivirus - genetics ; Hepatitis B e Antigens - immunology ; Hepatitis B Surface Antigens - immunology ; Hepatitis B virus - genetics ; Hepatitis B virus - immunology ; Hepatitis B, Chronic - complications ; Hepatitis B, Chronic - metabolism ; Hepatitis B, Chronic - pathology ; Hepatitis C, Chronic - complications ; Hepatitis C, Chronic - genetics ; Hepatitis C, Chronic - metabolism ; Humans ; Immunoenzyme Techniques ; Male ; Middle Aged ; Polymerase Chain Reaction ; Prevalence ; Prognosis ; Retrospective Studies ; Steatosis</subject><ispartof>Digestive and liver disease, 2007-10, Vol.39 (10), p.936-942</ispartof><rights>Editrice Gastroenterologica Italiana S.r.l.</rights><rights>2007 Editrice Gastroenterologica Italiana S.r.l.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-10c19c10757bd4ffdef2cbc02d891b4444d6511715452461624a4ac3c7f09d33</citedby><cites>FETCH-LOGICAL-c406t-10c19c10757bd4ffdef2cbc02d891b4444d6511715452461624a4ac3c7f09d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1590865807004380$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17720637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsochatzis, E</creatorcontrib><creatorcontrib>Papatheodoridis, G.V</creatorcontrib><creatorcontrib>Manesis, E.K</creatorcontrib><creatorcontrib>Chrysanthos, N</creatorcontrib><creatorcontrib>Kafiri, G</creatorcontrib><creatorcontrib>Archimandritis, A.J</creatorcontrib><title>Hepatic steatosis in chronic hepatitis B develops due to host metabolic factors: A comparative approach with genotype 1 chronic hepatitis C</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>Abstract Background/aims Hepatic steatosis has not been adequately studied in chronic hepatitis B, while it is considered to be a cardinal feature in chronic hepatitis C and to be mainly metabolically induced in patients infected with genotype 1. We investigated the prevalence of and the parameters associated with steatosis in HBeAg-negative chronic hepatitis B. Methods We studied 213 patients with HBeAg-negative chronic hepatitis B and compared them with 163 patients with genotype-1 chronic hepatitis C. Steatosis was semi-quantitatively graded. Results Steatosis was significantly less frequent in chronic hepatitis B than chronic hepatitis C (60% versus 72%, P = 0.016), but there was no difference in the prevalence of moderate/severe steatosis. In chronic hepatitis B, steatosis was associated only with higher body mass index ( P = 0.002), while moderate/severe steatosis was associated only with higher body mass index ( P = 0.043) and diabetes ( P = 0.031). Steatosis was relatively less frequent in chronic hepatitis B than chronic hepatitis C non-diabetic, normal-weight patients (45.6% versus 62.5%, P = 0.063), but it did not differ in diabetic and/or overweight/obese patients with chronic hepatitis B or chronic hepatitis C. Conclusions Hepatic steatosis in HBeAg-negative chronic hepatitis B (a) is less frequent than in genotype-1 chronic hepatitis C, (b) is mainly associated with presence of host metabolic factors, such as high body mass index and diabetes and (c) does not seem to be associated with the severity of liver histological lesions.</description><subject>Biopsy</subject><subject>Body Mass Index</subject><subject>Chronic hepatitis B</subject><subject>Chronic hepatitis C</subject><subject>Diabetes Complications - complications</subject><subject>Diabetes Complications - metabolism</subject><subject>DNA, Viral - genetics</subject><subject>Fatty Liver - epidemiology</subject><subject>Fatty Liver - etiology</subject><subject>Fatty Liver - metabolism</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Genotype</subject><subject>Hepacivirus - genetics</subject><subject>Hepatitis B e Antigens - immunology</subject><subject>Hepatitis B Surface Antigens - immunology</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - immunology</subject><subject>Hepatitis B, Chronic - complications</subject><subject>Hepatitis B, Chronic - metabolism</subject><subject>Hepatitis B, Chronic - pathology</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Hepatitis C, Chronic - genetics</subject><subject>Hepatitis C, Chronic - metabolism</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Steatosis</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Ul2r1DAQLaJ4P_QH-CJ58q3rJG2SroJwXa5e4YIP3veQJlObtW1qkq7sb_BPm7oLgohhIMPknJNkzhTFCwobClS83m_sYDcMQG5yUE4fFZe0kU1ZccEe55xvoWwEby6Kqxj3AIwKDk-LCyolA1HJy-LnHc46OUNiQp18dJG4iZg--CkX-9-HKRffE4sHHPwciV2QJE96HxMZMenWDxnaaZN8iG_IDTF-nHXIxAMSPc_Ba9OTHy715CtOPh1nJPQfV-yeFU86PUR8ft6vi4cPtw-7u_L-88dPu5v70tQgUknB0K2hILlsbd11FjtmWgPMNlva1nlZwSmVlNec1YIKVutam8rIDra2qq6LVyfZ_LLvC8akRhcNDoOe0C9RiYZVjMMKpCegCT7GgJ2agxt1OCoKajVA7VU2QK0GqBzZgMx5eRZf2hHtH8a54xnw9gTA_MODw6CicTgZtC6gScp691_5d3-xzeByG_XwDY8Y934JU26doioyBerLOgHrAIAEqKsGql_Dm6yB</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Tsochatzis, E</creator><creator>Papatheodoridis, G.V</creator><creator>Manesis, E.K</creator><creator>Chrysanthos, N</creator><creator>Kafiri, G</creator><creator>Archimandritis, A.J</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Hepatic steatosis in chronic hepatitis B develops due to host metabolic factors: A comparative approach with genotype 1 chronic hepatitis C</title><author>Tsochatzis, E ; Papatheodoridis, G.V ; Manesis, E.K ; Chrysanthos, N ; Kafiri, G ; Archimandritis, A.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-10c19c10757bd4ffdef2cbc02d891b4444d6511715452461624a4ac3c7f09d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biopsy</topic><topic>Body Mass Index</topic><topic>Chronic hepatitis B</topic><topic>Chronic hepatitis C</topic><topic>Diabetes Complications - complications</topic><topic>Diabetes Complications - metabolism</topic><topic>DNA, Viral - genetics</topic><topic>Fatty Liver - epidemiology</topic><topic>Fatty Liver - etiology</topic><topic>Fatty Liver - metabolism</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Genotype</topic><topic>Hepacivirus - genetics</topic><topic>Hepatitis B e Antigens - immunology</topic><topic>Hepatitis B Surface Antigens - immunology</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - immunology</topic><topic>Hepatitis B, Chronic - complications</topic><topic>Hepatitis B, Chronic - metabolism</topic><topic>Hepatitis B, Chronic - pathology</topic><topic>Hepatitis C, Chronic - complications</topic><topic>Hepatitis C, Chronic - genetics</topic><topic>Hepatitis C, Chronic - metabolism</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Steatosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsochatzis, E</creatorcontrib><creatorcontrib>Papatheodoridis, G.V</creatorcontrib><creatorcontrib>Manesis, E.K</creatorcontrib><creatorcontrib>Chrysanthos, N</creatorcontrib><creatorcontrib>Kafiri, G</creatorcontrib><creatorcontrib>Archimandritis, A.J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsochatzis, E</au><au>Papatheodoridis, G.V</au><au>Manesis, E.K</au><au>Chrysanthos, N</au><au>Kafiri, G</au><au>Archimandritis, A.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatic steatosis in chronic hepatitis B develops due to host metabolic factors: A comparative approach with genotype 1 chronic hepatitis C</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>39</volume><issue>10</issue><spage>936</spage><epage>942</epage><pages>936-942</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>Abstract Background/aims Hepatic steatosis has not been adequately studied in chronic hepatitis B, while it is considered to be a cardinal feature in chronic hepatitis C and to be mainly metabolically induced in patients infected with genotype 1. We investigated the prevalence of and the parameters associated with steatosis in HBeAg-negative chronic hepatitis B. Methods We studied 213 patients with HBeAg-negative chronic hepatitis B and compared them with 163 patients with genotype-1 chronic hepatitis C. Steatosis was semi-quantitatively graded. Results Steatosis was significantly less frequent in chronic hepatitis B than chronic hepatitis C (60% versus 72%, P = 0.016), but there was no difference in the prevalence of moderate/severe steatosis. In chronic hepatitis B, steatosis was associated only with higher body mass index ( P = 0.002), while moderate/severe steatosis was associated only with higher body mass index ( P = 0.043) and diabetes ( P = 0.031). Steatosis was relatively less frequent in chronic hepatitis B than chronic hepatitis C non-diabetic, normal-weight patients (45.6% versus 62.5%, P = 0.063), but it did not differ in diabetic and/or overweight/obese patients with chronic hepatitis B or chronic hepatitis C. Conclusions Hepatic steatosis in HBeAg-negative chronic hepatitis B (a) is less frequent than in genotype-1 chronic hepatitis C, (b) is mainly associated with presence of host metabolic factors, such as high body mass index and diabetes and (c) does not seem to be associated with the severity of liver histological lesions.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>17720637</pmid><doi>10.1016/j.dld.2007.07.151</doi><tpages>7</tpages></addata></record> |
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| subjects | Biopsy Body Mass Index Chronic hepatitis B Chronic hepatitis C Diabetes Complications - complications Diabetes Complications - metabolism DNA, Viral - genetics Fatty Liver - epidemiology Fatty Liver - etiology Fatty Liver - metabolism Female Gastroenterology and Hepatology Genotype Hepacivirus - genetics Hepatitis B e Antigens - immunology Hepatitis B Surface Antigens - immunology Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B, Chronic - complications Hepatitis B, Chronic - metabolism Hepatitis B, Chronic - pathology Hepatitis C, Chronic - complications Hepatitis C, Chronic - genetics Hepatitis C, Chronic - metabolism Humans Immunoenzyme Techniques Male Middle Aged Polymerase Chain Reaction Prevalence Prognosis Retrospective Studies Steatosis |
| title | Hepatic steatosis in chronic hepatitis B develops due to host metabolic factors: A comparative approach with genotype 1 chronic hepatitis C |
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