Simultaneous MRI and PET imaging of a rat brain
Multi-modality imaging is rapidly becoming a valuable tool in the diagnosis of disease and in the development of new drugs. Functional images produced with PET fused with anatomical structure images created by MRI will allow the correlation of form with function. Our group is developing a system to...
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| Veröffentlicht in: | Physics in medicine & biology 2006-12, Vol.51 (24), p.6371-6379 |
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| container_issue | 24 |
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| container_title | Physics in medicine & biology |
| container_volume | 51 |
| creator | Raylman, Raymond R Majewski, Stan Lemieux, Susan K Velan, S Sendhil Kross, Brian Popov, Vladimir Smith, Mark F Weisenberger, Andrew G Zorn, Carl Marano, Gary D |
| description | Multi-modality imaging is rapidly becoming a valuable tool in the diagnosis of disease and in the development of new drugs. Functional images produced with PET fused with anatomical structure images created by MRI will allow the correlation of form with function. Our group is developing a system to acquire MRI and PET images contemporaneously. The prototype device consists of two opposed detector heads, operating in coincidence mode. Each MRI-PET detector module consists of an array of LSO detector elements coupled through a long fibre optic light guide to a single Hamamatsu flat panel position-sensitive photomultiplier tube (PSPMT). The use of light guides allows the PSPMTs to be positioned outside the bore of a 3T MRI scanner where the magnetic field is relatively small. To test the device, simultaneous MRI and PET images of the brain of a male Sprague Dawley rat injected with FDG were successfully obtained. The images revealed no noticeable artefacts in either image set. Future work includes the construction of a full ring PET scanner, improved light guides and construction of a specialized MRI coil to permit higher quality MRI imaging. |
| doi_str_mv | 10.1088/0031-9155/51/24/006 |
| format | Article |
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Functional images produced with PET fused with anatomical structure images created by MRI will allow the correlation of form with function. Our group is developing a system to acquire MRI and PET images contemporaneously. The prototype device consists of two opposed detector heads, operating in coincidence mode. Each MRI-PET detector module consists of an array of LSO detector elements coupled through a long fibre optic light guide to a single Hamamatsu flat panel position-sensitive photomultiplier tube (PSPMT). The use of light guides allows the PSPMTs to be positioned outside the bore of a 3T MRI scanner where the magnetic field is relatively small. To test the device, simultaneous MRI and PET images of the brain of a male Sprague Dawley rat injected with FDG were successfully obtained. The images revealed no noticeable artefacts in either image set. 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| source | Institute of Physics Journals; MEDLINE |
| subjects | Algorithms Animals Brain - diagnostic imaging Brain - pathology Diagnostic Imaging - methods Equipment Design Image Processing, Computer-Assisted Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Male Positron-Emission Tomography - instrumentation Positron-Emission Tomography - methods Radiography Rats Rats, Sprague-Dawley Reproducibility of Results Time Factors |
| title | Simultaneous MRI and PET imaging of a rat brain |
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