The Association of Major Depression, Conduct Disorder, and Maternal Overcontrol with a Failure to Show a Cortisol Buffered Response in 4-Month-Old Infants of Teenage Mothers
Background Adolescent pregnancy can be associated with major depression (MD) and conduct disorder (CD). Some infants of adolescent mothers are prenatally exposed to these factors, which may result in heightened risk for perturbations of their stress systems. Between 2 and 4 months, a normal shift oc...
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description | Background Adolescent pregnancy can be associated with major depression (MD) and conduct disorder (CD). Some infants of adolescent mothers are prenatally exposed to these factors, which may result in heightened risk for perturbations of their stress systems. Between 2 and 4 months, a normal shift occurs in the adrenocortical system in which we observe a marked decrease in infant cortisol response when facing mild stressors. This study aimed to explore whether MD (lifetime, during pregnancy, postpartum), CD, and maternal overcontrol are associated with increased cortisol reactivity in 4-month-old infants of teenage mothers. Methods Using arm restraint as a stressor, morning salivary cortisol was taken prestressor and poststressor in 212 infants during a laboratory visit. Major depression and CD were measured with the computerized National Institute of Mental Health Diagnostic Interview Schedule (NIMH-DIS), postpartum depressive mood was measured with the Edinburgh Postnatal Depression Scale, and overcontrol was observed with the CARE-Index. Results Independent of the predictors, there was a dampened cortisol response. Infants of mothers with lifetime MD and of average to highly overcontrolling mothers showed increased cortisol reactivity. Conduct disorder and cortisol levels were not associated. Conclusions Future studies should detect whether the absence of a dampened cortisol response in infants whose mothers have lifetime MD or display overcontrolling parenting is stable over time. |
doi_str_mv | 10.1016/j.biopsych.2006.11.009 |
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Some infants of adolescent mothers are prenatally exposed to these factors, which may result in heightened risk for perturbations of their stress systems. Between 2 and 4 months, a normal shift occurs in the adrenocortical system in which we observe a marked decrease in infant cortisol response when facing mild stressors. This study aimed to explore whether MD (lifetime, during pregnancy, postpartum), CD, and maternal overcontrol are associated with increased cortisol reactivity in 4-month-old infants of teenage mothers. Methods Using arm restraint as a stressor, morning salivary cortisol was taken prestressor and poststressor in 212 infants during a laboratory visit. Major depression and CD were measured with the computerized National Institute of Mental Health Diagnostic Interview Schedule (NIMH-DIS), postpartum depressive mood was measured with the Edinburgh Postnatal Depression Scale, and overcontrol was observed with the CARE-Index. Results Independent of the predictors, there was a dampened cortisol response. Infants of mothers with lifetime MD and of average to highly overcontrolling mothers showed increased cortisol reactivity. Conduct disorder and cortisol levels were not associated. Conclusions Future studies should detect whether the absence of a dampened cortisol response in infants whose mothers have lifetime MD or display overcontrolling parenting is stable over time.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2006.11.009</identifier><identifier>PMID: 17336943</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult and adolescent clinical studies ; Biological and medical sciences ; Conduct disorder ; Conduct Disorder - diagnosis ; Conduct Disorder - epidemiology ; Depression ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - epidemiology ; Diagnosis, Computer-Assisted ; Female ; Humans ; Hydrocortisone - analysis ; Hydrocortisone - biosynthesis ; Infant ; Infant Behavior - physiology ; Infant Behavior - psychology ; infant cortisol ; Life Change Events ; Longitudinal Studies ; major depression ; Maternal Behavior - psychology ; maternal overcontrol ; Medical sciences ; Mood disorders ; Mother-Child Relations ; Pregnancy ; Pregnancy in Adolescence - physiology ; Psychiatric Status Rating Scales - statistics & numerical data ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Saliva - chemistry ; Stress, Psychological - metabolism</subject><ispartof>Biological psychiatry (1969), 2007-09, Vol.62 (6), p.573-579</ispartof><rights>Society of Biological Psychiatry</rights><rights>2007 Society of Biological Psychiatry</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-28f6e13d441b7208068f0f5598a74673c083913fb264bc83f1626798a8e4c3733</citedby><cites>FETCH-LOGICAL-c482t-28f6e13d441b7208068f0f5598a74673c083913fb264bc83f1626798a8e4c3733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322306014685$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19066048$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17336943$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azar, Rima</creatorcontrib><creatorcontrib>Paquette, Daniel</creatorcontrib><creatorcontrib>Zoccolillo, Mark</creatorcontrib><creatorcontrib>Baltzer, Franziska</creatorcontrib><creatorcontrib>Tremblay, Richard E</creatorcontrib><title>The Association of Major Depression, Conduct Disorder, and Maternal Overcontrol with a Failure to Show a Cortisol Buffered Response in 4-Month-Old Infants of Teenage Mothers</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background Adolescent pregnancy can be associated with major depression (MD) and conduct disorder (CD). Some infants of adolescent mothers are prenatally exposed to these factors, which may result in heightened risk for perturbations of their stress systems. Between 2 and 4 months, a normal shift occurs in the adrenocortical system in which we observe a marked decrease in infant cortisol response when facing mild stressors. This study aimed to explore whether MD (lifetime, during pregnancy, postpartum), CD, and maternal overcontrol are associated with increased cortisol reactivity in 4-month-old infants of teenage mothers. Methods Using arm restraint as a stressor, morning salivary cortisol was taken prestressor and poststressor in 212 infants during a laboratory visit. Major depression and CD were measured with the computerized National Institute of Mental Health Diagnostic Interview Schedule (NIMH-DIS), postpartum depressive mood was measured with the Edinburgh Postnatal Depression Scale, and overcontrol was observed with the CARE-Index. Results Independent of the predictors, there was a dampened cortisol response. Infants of mothers with lifetime MD and of average to highly overcontrolling mothers showed increased cortisol reactivity. Conduct disorder and cortisol levels were not associated. Conclusions Future studies should detect whether the absence of a dampened cortisol response in infants whose mothers have lifetime MD or display overcontrolling parenting is stable over time.</description><subject>Adolescent</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Conduct disorder</subject><subject>Conduct Disorder - diagnosis</subject><subject>Conduct Disorder - epidemiology</subject><subject>Depression</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Diagnosis, Computer-Assisted</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - analysis</subject><subject>Hydrocortisone - biosynthesis</subject><subject>Infant</subject><subject>Infant Behavior - physiology</subject><subject>Infant Behavior - psychology</subject><subject>infant cortisol</subject><subject>Life Change Events</subject><subject>Longitudinal Studies</subject><subject>major depression</subject><subject>Maternal Behavior - psychology</subject><subject>maternal overcontrol</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>Mother-Child Relations</subject><subject>Pregnancy</subject><subject>Pregnancy in Adolescence - physiology</subject><subject>Psychiatric Status Rating Scales - statistics & numerical data</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Saliva - chemistry</subject><subject>Stress, Psychological - metabolism</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9uEzEQxlcIREvhFSpf4NQN_rPxOhdESSlUahSJhrPleGdZh42deryt8lC8I14lqBKXnizP_Oab0XxTFOeMThhl8uNmsnZhh3vbTTilcsLYhNLZi-KUqVqUvKL8ZXFKc6YUnIuT4g3iJn9rztnr4oTVQshZJU6LP6sOyCVisM4kFzwJLVmYTYjkCnYREHPsgsyDbwabyJXDEBuIF8T4JnMJojc9WT5AtMGnGHry6FJHDLk2rh8ikBTIXRcec2QeYsrlPfkytC1EaMgPwF3wCMR5UpWLLNCVy74hN741PuE4ygrAm19AFiF1EPFt8ao1PcK743tW_Lz-upp_L2-X327ml7elrRRPJVetBCaaqmLrmlNFpWppO53OlKkrWQtLlZgx0a65rNZWiZZJLuucVVBZkXdzVnw46O5iuB8Ak946tND3xkMYUEvF-ZRO-bMgp1LWko-K8gDaGBAjtHoX3dbEvWZUj47qjf7nqB4d1Yzp7GguPD92GNZbaJ7KjhZm4P0RMGhN30bjrcMnbpZHoJXK3OcDB3lxDw6iRuvAW2hcBJt0E9zzs3z6T8L2zrvc9TfsATdhGM8BNdPINdV34_2N50clZZVUU_EXxY7XSA</recordid><startdate>20070915</startdate><enddate>20070915</enddate><creator>Azar, Rima</creator><creator>Paquette, Daniel</creator><creator>Zoccolillo, Mark</creator><creator>Baltzer, Franziska</creator><creator>Tremblay, Richard E</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20070915</creationdate><title>The Association of Major Depression, Conduct Disorder, and Maternal Overcontrol with a Failure to Show a Cortisol Buffered Response in 4-Month-Old Infants of Teenage Mothers</title><author>Azar, Rima ; Paquette, Daniel ; Zoccolillo, Mark ; Baltzer, Franziska ; Tremblay, Richard E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-28f6e13d441b7208068f0f5598a74673c083913fb264bc83f1626798a8e4c3733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Conduct disorder</topic><topic>Conduct Disorder - diagnosis</topic><topic>Conduct Disorder - epidemiology</topic><topic>Depression</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - epidemiology</topic><topic>Diagnosis, Computer-Assisted</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - analysis</topic><topic>Hydrocortisone - biosynthesis</topic><topic>Infant</topic><topic>Infant Behavior - physiology</topic><topic>Infant Behavior - psychology</topic><topic>infant cortisol</topic><topic>Life Change Events</topic><topic>Longitudinal Studies</topic><topic>major depression</topic><topic>Maternal Behavior - psychology</topic><topic>maternal overcontrol</topic><topic>Medical sciences</topic><topic>Mood disorders</topic><topic>Mother-Child Relations</topic><topic>Pregnancy</topic><topic>Pregnancy in Adolescence - physiology</topic><topic>Psychiatric Status Rating Scales - statistics & numerical data</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Saliva - chemistry</topic><topic>Stress, Psychological - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azar, Rima</creatorcontrib><creatorcontrib>Paquette, Daniel</creatorcontrib><creatorcontrib>Zoccolillo, Mark</creatorcontrib><creatorcontrib>Baltzer, Franziska</creatorcontrib><creatorcontrib>Tremblay, Richard E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azar, Rima</au><au>Paquette, Daniel</au><au>Zoccolillo, Mark</au><au>Baltzer, Franziska</au><au>Tremblay, Richard E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Association of Major Depression, Conduct Disorder, and Maternal Overcontrol with a Failure to Show a Cortisol Buffered Response in 4-Month-Old Infants of Teenage Mothers</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2007-09-15</date><risdate>2007</risdate><volume>62</volume><issue>6</issue><spage>573</spage><epage>579</epage><pages>573-579</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background Adolescent pregnancy can be associated with major depression (MD) and conduct disorder (CD). Some infants of adolescent mothers are prenatally exposed to these factors, which may result in heightened risk for perturbations of their stress systems. Between 2 and 4 months, a normal shift occurs in the adrenocortical system in which we observe a marked decrease in infant cortisol response when facing mild stressors. This study aimed to explore whether MD (lifetime, during pregnancy, postpartum), CD, and maternal overcontrol are associated with increased cortisol reactivity in 4-month-old infants of teenage mothers. Methods Using arm restraint as a stressor, morning salivary cortisol was taken prestressor and poststressor in 212 infants during a laboratory visit. Major depression and CD were measured with the computerized National Institute of Mental Health Diagnostic Interview Schedule (NIMH-DIS), postpartum depressive mood was measured with the Edinburgh Postnatal Depression Scale, and overcontrol was observed with the CARE-Index. Results Independent of the predictors, there was a dampened cortisol response. Infants of mothers with lifetime MD and of average to highly overcontrolling mothers showed increased cortisol reactivity. Conduct disorder and cortisol levels were not associated. Conclusions Future studies should detect whether the absence of a dampened cortisol response in infants whose mothers have lifetime MD or display overcontrolling parenting is stable over time.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17336943</pmid><doi>10.1016/j.biopsych.2006.11.009</doi><tpages>7</tpages></addata></record> |
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subjects | Adolescent Adult and adolescent clinical studies Biological and medical sciences Conduct disorder Conduct Disorder - diagnosis Conduct Disorder - epidemiology Depression Depressive Disorder, Major - diagnosis Depressive Disorder, Major - epidemiology Diagnosis, Computer-Assisted Female Humans Hydrocortisone - analysis Hydrocortisone - biosynthesis Infant Infant Behavior - physiology Infant Behavior - psychology infant cortisol Life Change Events Longitudinal Studies major depression Maternal Behavior - psychology maternal overcontrol Medical sciences Mood disorders Mother-Child Relations Pregnancy Pregnancy in Adolescence - physiology Psychiatric Status Rating Scales - statistics & numerical data Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Saliva - chemistry Stress, Psychological - metabolism |
title | The Association of Major Depression, Conduct Disorder, and Maternal Overcontrol with a Failure to Show a Cortisol Buffered Response in 4-Month-Old Infants of Teenage Mothers |
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