Involvement of glutamatergic receptors in the nucleus cuneiformis in modulating morphine-induced antinociception in rats

Abstract The nucleus cuneiformis (CnF), located just ventrolateral to the periaqueductal gray, is part of the descending pain modulatory system. Neurons in the CnF project to medullary nucleus raphe magnus (NRM), which plays an important role on pain modulation. In this study, we investigated the ef...

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Veröffentlicht in:	European journal of pain 2007-11, Vol.11 (8), p.855-862
Hauptverfasser:	Haghparast, Abbas, Gheitasi, Izad-Panah, Lashgari, Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - analogs & derivatives 2-Amino-5-phosphonovalerate - pharmacology Analgesics, Opioid - pharmacology Anesthesia & Perioperative Care Animals Dizocilpine Maleate - pharmacology Excitatory Amino Acid Antagonists - pharmacology Kainate/AMPA receptor Male Microinjections Morphine Morphine - pharmacology NMDA receptor Nociceptors - drug effects Nociceptors - physiology Nucleus cuneiformis Opioid receptor Pain - drug therapy Pain - physiopathology Pain Medicine Pain modulation Quinoxalines - pharmacology Rats Rats, Inbred Strains Reaction Time - drug effects Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - physiology Receptors, Glutamate - physiology Receptors, Kainic Acid - antagonists & inhibitors Receptors, Kainic Acid - physiology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - physiology Tegmentum Mesencephali - drug effects Tegmentum Mesencephali - physiology
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