Inhibition of growth and angiogenesis of U251 cell xenograft in vivo by short hairpin RNA targeting survivin gene

To observe the impact of specific short hairpin RNA (shRNA) targeting survivin gene on tumorigenesis and angiogenesis of human brain glioblastoma U251 cells in vivo of nude mice. U251 cells, U251-SR cells transfected stably with shRNA eukaryotic expression vector pWH1-SR targeting survivin gene, and...

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Veröffentlicht in:	Chung-hua wai kʿo tsa chih 2006-09, Vol.44 (18), p.1270-1274
Hauptverfasser:	Zhen, Hai-ning, Zhang, Xiang, Shi, Chang-hong, Yang, Tong-tao, Fu, Luo-an, Zhang, Wei, Wang, Xi-ling, Gao, Da-kuan, Hu, Shi-jie, Song, Lei
Format:	Artikel
Sprache:	chi
Schlagworte:	Animals Apoptosis Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Line, Tumor Female Glioblastoma - metabolism Glioblastoma - pathology Humans Inhibitor of Apoptosis Proteins Male Mice Mice, Nude Microtubule-Associated Proteins - biosynthesis Microtubule-Associated Proteins - genetics Neoplasm Transplantation Neovascularization, Pathologic - pathology Repressor Proteins RNA Interference RNA, Small Interfering - genetics Transfection
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