Transbilayer pores induced by thickness fluctuations
Thermally-induced fluctuations of individual phospholipids in a bilayer lipid membrane (BLM) are converted into collective motions due to the intermolecular interactions. Here, we demonstrate that transbilayer stochastic pores can be generated via collective thermal movements (CTM). Using the elasti...
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| Veröffentlicht in: | Bulletin of mathematical biology 2006-08, Vol.68 (6), p.1231-1255 |
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| creator | Movileanu, Liviu Popescu, Dumitru Ion, Stelian Popescu, Aurel I |
| description | Thermally-induced fluctuations of individual phospholipids in a bilayer lipid membrane (BLM) are converted into collective motions due to the intermolecular interactions. Here, we demonstrate that transbilayer stochastic pores can be generated via collective thermal movements (CTM). Using the elastic theory of continuous media applied to smectic-A liquid crystals, we estimate the pore radius and the energetic requirements for pore appearance. Three types of thermally-induced transbilayer pores could be formed through BLMs: open and stable, open and unstable, and closed. In most of the situations, two open and stable pores with different radii could be generated. Notably, the two pores have the same generation probability. Unstable pores are possible to appear across thin bilayers that contain phospholipids with a large polar headgroup. Closed pores are present throughout the cases that we have inspected. The effects of hydrophobic thickness, polar headgroup size of phospholipids, temperature, surface tension, and elastic compression on the pore formation and pore stability have been examined as well. |
| doi_str_mv | 10.1007/s11538-006-9069-9 |
| format | Article |
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Here, we demonstrate that transbilayer stochastic pores can be generated via collective thermal movements (CTM). Using the elastic theory of continuous media applied to smectic-A liquid crystals, we estimate the pore radius and the energetic requirements for pore appearance. Three types of thermally-induced transbilayer pores could be formed through BLMs: open and stable, open and unstable, and closed. In most of the situations, two open and stable pores with different radii could be generated. Notably, the two pores have the same generation probability. Unstable pores are possible to appear across thin bilayers that contain phospholipids with a large polar headgroup. Closed pores are present throughout the cases that we have inspected. 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Here, we demonstrate that transbilayer stochastic pores can be generated via collective thermal movements (CTM). Using the elastic theory of continuous media applied to smectic-A liquid crystals, we estimate the pore radius and the energetic requirements for pore appearance. Three types of thermally-induced transbilayer pores could be formed through BLMs: open and stable, open and unstable, and closed. In most of the situations, two open and stable pores with different radii could be generated. Notably, the two pores have the same generation probability. Unstable pores are possible to appear across thin bilayers that contain phospholipids with a large polar headgroup. Closed pores are present throughout the cases that we have inspected. The effects of hydrophobic thickness, polar headgroup size of phospholipids, temperature, surface tension, and elastic compression on the pore formation and pore stability have been examined as well.</description><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Lipid Bilayers - chemistry</subject><subject>Models, Chemical</subject><subject>Phospholipids - chemistry</subject><subject>Stochastic Processes</subject><issn>0092-8240</issn><issn>1522-9602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkDtPwzAUhS0EoqXwA1hQxMBmuH7bI6p4SZVYymw5jiNS0qTYyZB_j6tWQmJhust3ju75ELomcE8A1EMiRDCNASQ2IA02J2hOBKXYSKCnaA5gKNaUwwxdpLSBnDHMnKMZUYQbTcQc8XV0XSqb1k0hFrs-hlQ0XTX6UBXlVAyfjf_qQkpF3Y5-GN3Q9F26RGe1a1O4Ot4F-nh-Wi9f8er95W35uMKeUzZgUxonpA5QCqVAc1HrwF1JgxCGcqorwYiklSAKiNHeV8BrTbWqhTc1c5It0N2hdxf77zGkwW6b5EPbui70Y7JS0zwO4F-QgqQy783g7R9w04-xyyOsYvlp0ExliBwgH_uUYqjtLjZbFydLwO7F24N4m8XbvXhrcubmWDyW21D9Jo6m2Q-xsHwT</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Movileanu, Liviu</creator><creator>Popescu, Dumitru</creator><creator>Ion, Stelian</creator><creator>Popescu, Aurel I</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SS</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>K9.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7S</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>Transbilayer pores induced by thickness fluctuations</title><author>Movileanu, Liviu ; 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| subjects | Hydrophobic and Hydrophilic Interactions Lipid Bilayers - chemistry Models, Chemical Phospholipids - chemistry Stochastic Processes |
| title | Transbilayer pores induced by thickness fluctuations |
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