Gelatin microspheres cross-linked with EDC as a drug delivery system for doxycyline: Development and characterization

Chronic wounds express elevated levels of proteases, in particular matrix metalloproteinases (MMPs), which degrades de novo granulation tissue and endogenous biologically active proteins. An effective therapeutic approach for chronic wounds would be to modify this hostile environment and reduce the...

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Veröffentlicht in:	Journal of microencapsulation 2007-01, Vol.24 (7), p.659-671
Hauptverfasser:	Adhirajan, N., Shanmugasundaram, N., Babu, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals biocompatibility Biocompatible Materials - chemistry Biological and medical sciences carbodiimide Chemistry, Pharmaceutical - methods Collagenases - chemistry cross-linking Cross-Linking Reagents - pharmacology Doxycycline - administration & dosage doxycycline hyclate Drug Delivery Systems enzymatic degradation Ethyldimethylaminopropyl Carbodiimide - chemistry Fibroblasts - metabolism Gelatin - chemistry Gelatin microspheres General pharmacology Medical sciences Mice Microscopy, Electron, Scanning Microspheres NIH 3T3 Cells Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Time Factors
Online-Zugang:	Volltext
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