POU5F1 Isoforms Show Different Expression Patterns in Human Embryonic Stem Cells and Preimplantation Embryos

The contribution of the POU domain, class 5, transcription factor‐1 (POU5F1) in maintaining totipotency in human embryonic stem cells (hESCs) has been repeatedly proven. In humans, two isoforms are encoded: POU5F1_iA and POU5F1_iB. So far, no discrimination has been made between the isoforms in POU5...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2006-12, Vol.24 (12), p.2685-2691
Hauptverfasser:	Cauffman, Greet, Liebaers, Inge, Van Steirteghem, André, Van de Velde, Hilde
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics Blastocyst - cytology Blastocyst - metabolism Cell Differentiation Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Human embryonic stem cells Human preimplantation embryos Humans Octamer Transcription Factor-3 - chemistry Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - immunology Octamer Transcription Factor-3 - metabolism OCT‐4 Oocytes - cytology Oocytes - metabolism POU5F1 Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - immunology Protein Isoforms - metabolism Stem cell marker Totipotency
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