Long-term persistence of gene expression from adeno-associated virus serotype 5 in the mouse airways

Recombinant adeno-associated virus vectors based on serotype 2 (rAAV2) have been used to deliver transgenes to the airways in a variety of pre-clinical and clinical studies. Gene transfer in these studies has been severely restricted by the basolateral localization of rAAV2 receptors. Here, we studi...

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Veröffentlicht in:	Gene therapy 2006-12, Vol.13 (24), p.1703-1713
Hauptverfasser:	Sumner-Jones, S G, Davies, L A, Varathalingam, A, Gill, D R, Hyde, S C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Adenoviruses Alveoli Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antibodies - blood Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Care and treatment Cell Biology Cercopithecus aethiops COS Cells Cystic fibrosis Dependovirus - genetics Enzyme-Linked Immunosorbent Assay - methods Epithelial cells Errors of metabolism Expression vectors Female Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genetic aspects Genetic Engineering Genetic Therapy - methods Genetic Vectors - administration & dosage Genomes Green Fluorescent Proteins - genetics Health. Pharmaceutical industry Hemophilia B Human Genetics Immune response Industrial applications and implications. Economical aspects Localization Luciferases - genetics Luciferases - metabolism Lung - metabolism Lungs Medical sciences Metabolic diseases Mice Mice, Inbred BALB C Miscellaneous hereditary metabolic disorders Nanotechnology Nasal Mucosa - metabolism Nose Olfactory epithelium original-article Physiological aspects Respiratory Mucosa - metabolism Respiratory tract Risk factors Rodents Serotyping Time Factors Transduction, Genetic - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transgenes
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