Identification of a novel tumor transforming gene GAEC1 at 7q22 which encodes a nuclear protein and is frequently amplified and overexpressed in esophageal squamous cell carcinoma

By comparative DNA fingerprinting, we identified a 357-bp DNA fragment frequently amplified in esophageal squamous cell carcinomas (ESCC). This fragment overlaps with an expressed sequence tag mapped to 7q22. Further 5′ and 3′-rapid amplification of cDNA ends revealed that it is part of a novel, sin...

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Veröffentlicht in:	Oncogene 2007-08, Vol.26 (40), p.5877-5888
Hauptverfasser:	Law, F B F, Chen, Y W, Wong, K Y, Ying, J, Tao, Q, Langford, C, Lee, P Y, Law, S, Cheung, R W L, Chui, C H, Tsao, S W, Lam, K Y, Wong, J, Srivastava, G, Tang, J C O
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Apoptosis Base Sequence Biological and medical sciences Cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Cell Biology Cell Line, Tumor Cell Nucleus - metabolism Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular proteins Chromosome 7 Chromosomes, Human, Pair 7 Diagnosis DNA fingerprinting DNA fingerprints DNA testing Esophageal cancer Esophageal carcinoma Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophagus Expressed sequence tags Fibroblasts Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genomics H-Ras protein Human Genetics Humans Hybridization Internal Medicine Medical sciences Medicine Medicine & Public Health Mice Mice, Nude Models, Genetic Molecular and cellular biology Molecular Sequence Data mRNA Neoplasm Transplantation Nuclear Proteins - biosynthesis Nuclear Proteins - genetics Oncology original-article Physiological aspects Proteins Rodents Sarcoma Squamous cell carcinoma Tumors
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