Aurora Kinases: New Targets for Cancer Therapy
The Aurora kinase family is a collection of highly related serine/threonine kinases that functions as a key regulator of mitosis. In mammalian cells, Aurora has evolved into three related kinases known as Aurora-A, Aurora-B, and Aurora-C. These kinases are overexpressed in a number of human cancers,...
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| Veröffentlicht in: | Clinical cancer research 2006-12, Vol.12 (23), p.6869-6875 |
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| container_title | Clinical cancer research |
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| creator | CARVAJAL, Richard D TSE, Archie SCHWARTZ, Gary K |
| description | The Aurora kinase family is a collection of highly related serine/threonine kinases that functions as a key regulator of mitosis.
In mammalian cells, Aurora has evolved into three related kinases known as Aurora-A, Aurora-B, and Aurora-C. These kinases
are overexpressed in a number of human cancers, and transfection studies have established Aurora-A as a bone fide oncogene.
Because Aurora overexpression is associated with malignancy, these kinases have been targeted for cancer therapy. This article
reviews the multiple functions of Aurora kinase in the regulation of mitosis and the mitotic checkpoint, the role of abnormal
Aurora kinase activity in the development of cancer, the putative mechanisms of Aurora kinase inhibition and its antitumor
effects, the development of the first generation of Aurora kinase inhibitors, and prospects for the future of Aurora kinase
inhibition in the treatment of cancer. |
| doi_str_mv | 10.1158/1078-0432.CCR-06-1405 |
| format | Article |
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In mammalian cells, Aurora has evolved into three related kinases known as Aurora-A, Aurora-B, and Aurora-C. These kinases
are overexpressed in a number of human cancers, and transfection studies have established Aurora-A as a bone fide oncogene.
Because Aurora overexpression is associated with malignancy, these kinases have been targeted for cancer therapy. This article
reviews the multiple functions of Aurora kinase in the regulation of mitosis and the mitotic checkpoint, the role of abnormal
Aurora kinase activity in the development of cancer, the putative mechanisms of Aurora kinase inhibition and its antitumor
effects, the development of the first generation of Aurora kinase inhibitors, and prospects for the future of Aurora kinase
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In mammalian cells, Aurora has evolved into three related kinases known as Aurora-A, Aurora-B, and Aurora-C. These kinases
are overexpressed in a number of human cancers, and transfection studies have established Aurora-A as a bone fide oncogene.
Because Aurora overexpression is associated with malignancy, these kinases have been targeted for cancer therapy. This article
reviews the multiple functions of Aurora kinase in the regulation of mitosis and the mitotic checkpoint, the role of abnormal
Aurora kinase activity in the development of cancer, the putative mechanisms of Aurora kinase inhibition and its antitumor
effects, the development of the first generation of Aurora kinase inhibitors, and prospects for the future of Aurora kinase
inhibition in the treatment of cancer.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Aurora kinase A</subject><subject>Aurora Kinase B</subject><subject>Aurora Kinase C</subject><subject>Aurora Kinases</subject><subject>Biological and medical sciences</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mitotic checkpoint</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - enzymology</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein Kinase Inhibitors - pharmacology</subject><subject>Protein Kinase Inhibitors - therapeutic use</subject><subject>Protein-Serine-Threonine Kinases - antagonists & inhibitors</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M9LwzAUwPEgipvTP0HpRcFDZ17SpK23UfyFQ0HmOaTpy1rZ1pmsjP33tq6yo6fk8Hkv5EvIJdAxgEjugMZJSCPOxln2EVIZQkTFERmCEHHImRTH7f3PDMiZ91-UQgQ0OiUDiCESCeVDMp40rnY6eK1W2qO_D95wG8y0m-PGB7Z2QaZXBl0wK9Hp9e6cnFi98HjRnyPy-fgwy57D6fvTSzaZhkaA2ISsYAw5NxatpLnEGE2aa8GMYQkUBbUpS1HLKJcWczSFTrVIWR6DpokEWvARudnvXbv6u0G_UcvKG1ws9ArrxiuZMJCS838hozGXkMgWij00rvbeoVVrVy212ymgqiuqulqqq6XaoopK1RVt5676B5p8icVhqk_YguseaG_0wro2WOUPLuGC85i17nbvympebiuHyvymdehRO1MqYIrx9mcy5T9rD4t-</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>CARVAJAL, Richard D</creator><creator>TSE, Archie</creator><creator>SCHWARTZ, Gary K</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Aurora Kinases: New Targets for Cancer Therapy</title><author>CARVAJAL, Richard D ; TSE, Archie ; SCHWARTZ, Gary K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-2d22e33cfef60b6e7ec9ba52cc281dd0f929ea64b6febecda9a592b71a08610d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Aurora kinase A</topic><topic>Aurora Kinase B</topic><topic>Aurora Kinase C</topic><topic>Aurora Kinases</topic><topic>Biological and medical sciences</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mitotic checkpoint</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - enzymology</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Kinase Inhibitors - pharmacology</topic><topic>Protein Kinase Inhibitors - therapeutic use</topic><topic>Protein-Serine-Threonine Kinases - antagonists & inhibitors</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CARVAJAL, Richard D</creatorcontrib><creatorcontrib>TSE, Archie</creatorcontrib><creatorcontrib>SCHWARTZ, Gary K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CARVAJAL, Richard D</au><au>TSE, Archie</au><au>SCHWARTZ, Gary K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aurora Kinases: New Targets for Cancer Therapy</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>12</volume><issue>23</issue><spage>6869</spage><epage>6875</epage><pages>6869-6875</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>The Aurora kinase family is a collection of highly related serine/threonine kinases that functions as a key regulator of mitosis.
In mammalian cells, Aurora has evolved into three related kinases known as Aurora-A, Aurora-B, and Aurora-C. These kinases
are overexpressed in a number of human cancers, and transfection studies have established Aurora-A as a bone fide oncogene.
Because Aurora overexpression is associated with malignancy, these kinases have been targeted for cancer therapy. This article
reviews the multiple functions of Aurora kinase in the regulation of mitosis and the mitotic checkpoint, the role of abnormal
Aurora kinase activity in the development of cancer, the putative mechanisms of Aurora kinase inhibition and its antitumor
effects, the development of the first generation of Aurora kinase inhibitors, and prospects for the future of Aurora kinase
inhibition in the treatment of cancer.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>17145803</pmid><doi>10.1158/1078-0432.CCR-06-1405</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical cancer research, 2006-12, Vol.12 (23), p.6869-6875 |
| issn | 1078-0432 1557-3265 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library; Highwire Press American Association for Cancer Research - AACR Journals |
| subjects | Animals Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Aurora kinase A Aurora Kinase B Aurora Kinase C Aurora Kinases Biological and medical sciences Humans Medical sciences Mitotic checkpoint Neoplasms - drug therapy Neoplasms - enzymology Pharmacology. Drug treatments Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism |
| title | Aurora Kinases: New Targets for Cancer Therapy |
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